Product image of Lastifluno (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Lastifluno

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Lastifluno (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine Hydrochloride and Fluticasone Propionate, the active ingredients in Lastifluno, are an antihistamine and a corticosteroid presented as a nasal spray for intranasal use. They treat seasonal and perennial allergic rhinitis by reducing nasal inflammation and histamine‑mediated symptoms in adults and children, providing relief from sneezing, itching, and congestion.

GNH India supplies Lastifluno as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Day Zero Ehf

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Indications & Clinical Uses

  • Lastifluno combines an antihistamine and a corticosteroid to manage allergic rhinitis and related nasal symptoms.
  • Seasonal allergic rhinitis: reduces sneezing, itching and nasal discharge.
  • Perennial allergic rhinitis: alleviates chronic nasal congestion and watery eyes.
  • Nasal congestion due to allergy: decreases mucosal swelling for easier breathing.

How It Works

  • Azelastine hydrochloride blocks H1 histamine receptors on nasal mucosal cells, preventing histamine‑induced itching, sneezing and vasodilation. Fluticasone propionate binds glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokine production, reduce vascular permeability, and diminish edema of the nasal passages, together providing rapid symptom relief.

Side Effects

Adverse reactions reported with intranasal azelastine‑fluticasone therapy are generally mild to moderate.

Common Side Effects

  • Bitter taste in the mouth
  • Nasal irritation or burning sensation
  • Headache
  • Sneezing shortly after use
  • Throat irritation

Serious or Rare Side Effects

  • Epistaxis (nosebleed)
  • Nasal septum perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes
  • Persistent nasal dryness

Precautions & Warnings

  • Before using Lastifluno, consider the following precautions.
  • Pregnancy: consult a healthcare provider before use.
  • Breastfeeding: limited data; use only if benefit outweighs potential risk.
  • Age restrictions: safety not established in children under 2 years.
  • Concomitant nasal surgery: postpone use until postoperative healing is complete.
  • Hypersensitivity: avoid if known allergy to azelastine, fluticasone, or excipients.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Potential drug interactions should be reviewed prior to initiating therapy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase systemic exposure to fluticasone.
  • Monoamine oxidase inhibitors (MAOIs): possible additive central nervous system effects with azelastine.

Moderate Interactions (Monitor Closely):\n- Anticholinergic agents: may exacerbate nasal dryness.

  • Other intranasal corticosteroids: risk of cumulative steroid exposure.
  • Alcohol: may enhance drowsiness associated with azelastine.

Frequently Asked Questions

Lastifluno is a combination nasal spray containing azelastine hydrochloride and fluticasone propionate. It is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis, including sneezing, nasal itching, runny nose, and congestion caused by allergic inflammation.

Azelastine hydrochloride is an H1‑histamine receptor antagonist. By blocking these receptors on nasal mucosal cells, it prevents histamine‑mediated responses such as itching, sneezing, and vasodilation, thereby reducing the immediate allergic symptoms experienced during rhinitis.

The dosing regimen for Lastifluno is determined by the prescribing clinician based on the patient’s age, severity of symptoms, and response to therapy. Typically, the spray is administered once or twice daily, but exact dosing instructions should be obtained from a qualified healthcare professional.

Safety data for Lastifluno in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lastifluno. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with monotherapy antihistamine sprays, Lastifluno adds a corticosteroid component, offering both rapid symptom relief and longer‑term reduction of nasal inflammation. This dual mechanism can provide superior control of congestion and mucosal edema for patients whose symptoms are not fully managed by a single‑agent therapy.

Store Lastifluno at room temperature, preferably below 25 °C, in its original packaging. Protect the bottle from moisture, excessive heat, and direct sunlight. Keep the spray cap tightly closed when not in use to maintain product stability.

Lastifluno is administered as an intranasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and press the actuator while breathing in gently. The same procedure is repeated in the other nostril if a bilateral dose is prescribed.

Serious adverse events, although rare, include nosebleeds (epistaxis), perforation of the nasal septum, severe allergic reactions such as anaphylaxis, and visual disturbances. Patients should seek immediate medical attention if they experience uncontrolled bleeding, sudden vision changes, or signs of a systemic allergic reaction.

Lastifluno should be avoided in individuals with known hypersensitivity to azelastine, fluticasone, or any of the formulation excipients. It is also contraindicated in patients who have experienced severe nasal septum perforation or uncontrolled nasal infections until the condition resolves.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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