Product image of Lastin (Azelastine) supplied by GNH India

Lastin

Active Ingredient:
Azelastine
Origin:
EU

Lastin (Azelastine)

Azelastine, the active ingredient in Lastin, is an antihistamine presented as a nasal spray for intranasal use. It blocks histamine H1 receptors to relieve symptoms of allergic rhinitis, such as sneezing, itching, and nasal congestion, in adults and children.

GNH India supplies Lastin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Our distribution network ensures timely delivery and reliable product traceability across multiple continents.

Manufacturer / TM Owner

Viatris Ab

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Indications & Clinical Uses

Azelastine nasal spray is used to treat allergic rhinitis by antagonizing H1 receptors in the nasal mucosa.

  • Seasonal allergic rhinitis: Reduces sneezing, itching, and nasal discharge.
  • Perennial allergic rhinitis: Improves nasal congestion and runny nose.
  • Non‑allergic rhinitis: Provides symptomatic relief of nasal irritation.
  • Hay fever: Alleviates typical allergy symptoms during pollen seasons.
  • Vasomotor rhinitis: Decreases nasal hyperreactivity and congestion.
  • Post‑operative nasal inflammation: Helps reduce swelling and irritation after nasal surgery.

How It Works

  • Azelastine acts as a selective H1‑receptor antagonist. By binding to H1 receptors on mast cells and sensory nerves in the nasal mucosa, it prevents histamine‑induced vasodilation, increased vascular permeability, and nerve stimulation. The drug also stabilises mast cells, reducing the release of histamine and other inflammatory mediators, thereby decreasing nasal congestion, itching, and rhinorrhoea. These actions collectively provide rapid relief of nasal allergy symptoms within minutes of administration.

Side Effects

Azelastine nasal spray may cause local and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Sneezing.
  • Headache.
  • Bitter taste.
  • Dry nose.
  • Cough.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Throat swelling.
  • Persistent nasal bleeding.
  • Vision changes.
  • Hallucinations or mood alterations.

Precautions & Warnings

When using Azelastine nasal spray, consider the following precautions to ensure safe and effective therapy.

  • Pregnancy: Consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: Discuss potential risks with a physician, as drug may be excreted in milk.
  • Age restrictions: Use in children only as directed by a prescriber.
  • Concomitant sedatives: Monitor for increased drowsiness when combined with CNS depressants.
  • Pre‑existing nasal conditions: Avoid use if nasal ulceration or severe infection is present.
  • Store at below 25°C: Keep in the original container, protect from moisture and heat.

Avoid Interactions

Azelastine may interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure.
  • Monoamine oxidase inhibitors (MAOIs): risk of additive antihistaminic effects.

Moderate Interactions (Monitor Closely)

  • Alcohol or CNS depressants: may enhance drowsiness or sedation.
  • Other antihistamines: combined use can increase sedation.
  • Nasal decongestant sprays: concurrent use may cause nasal irritation.
  • Anticholinergic agents: may exacerbate dry nasal mucosa.

Frequently Asked Questions

Lastin contains azelastine, an antihistamine formulated as a nasal spray. It is indicated for the relief of nasal symptoms associated with allergic rhinitis, including sneezing, itching, runny nose, and congestion, in both seasonal and perennial forms.

Azelastine works by selectively blocking H1 histamine receptors on mast cells and sensory nerves in the nasal mucosa. This prevents histamine‑induced inflammation, reduces vascular leakage, and stabilises mast cells, leading to rapid alleviation of allergy‑related nasal symptoms.

The dosage of Lastin is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the prescriber’s instructions and the product label for the correct number of sprays per dose.

Safety data for azelastine nasal spray in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lastin.

To order Lastin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with oral antihistamines, azelastine nasal spray delivers the active ingredient directly to the site of inflammation, often providing faster symptom relief with lower systemic exposure. It is generally well‑tolerated, though local nasal irritation may be more common than with oral formulations.

Store Lastin at temperatures below 25 °C, in its original packaging, protected from moisture and direct heat. Keep the bottle tightly closed when not in use and avoid exposing the spray to freezing conditions to maintain product stability.

Lastin is administered intranasally. The patient tilts the head slightly forward, inserts the spray tip into one nostril, and delivers the prescribed number of sprays while breathing in gently. The same procedure is repeated in the other nostril if required.

Serious adverse reactions are rare but may include anaphylaxis, severe throat swelling, persistent nosebleeds, visual disturbances, or neuropsychiatric effects such as hallucinations. Any of these symptoms require immediate medical attention and discontinuation of the product.

Lastin should be avoided in individuals with known hypersensitivity to azelastine or any component of the formulation. Patients with severe nasal ulceration, active infections, or those advised against nasal sprays by a physician should not use the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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