Product image of Lastin (Azelastine Hydrochloride) supplied by GNH India

Lastin

Active Ingredient:
Azelastine Hydrochloride
Origin:
EU

Lastin (Azelastine Hydrochloride)

Azelastine Hydrochloride, the active ingredient in Lastin, is a second‑generation antihistamine presented as a nasal spray for intranasal use. It treats allergic rhinitis, including seasonal and perennial forms, by relieving nasal congestion, itching, sneezing and rhinorrhea in adults and children.

GNH India supplies Lastin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Ab

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Indications & Clinical Uses

Lastin, a second‑generation antihistamine, is used to manage conditions within the allergic rhinitis disease family.

  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and runny nose.
  • Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or outdoor allergens.
  • Perennial allergic rhinitis: provides relief from year‑round indoor allergen‑induced nasal symptoms.

How It Works

  • Azelastine hydrochloride selectively blocks H1‑histamine receptors on nasal mucosal cells, preventing histamine‑mediated vasodilation, increased vascular permeability and sensory nerve activation. In addition, it stabilises mast cells, limiting the release of inflammatory mediators that contribute to allergic nasal symptoms.

Side Effects

Azelastine nasal spray may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nasal irritation or burning sensation
  • Bitter or unpleasant taste
  • Headache
  • Drowsiness or mild sedation
  • Dry mouth
  • Cough or throat clearing

Serious or Rare Side Effects

  • Anaphylactic reaction or severe allergy
  • Angioedema of the face or throat
  • Bronchospasm or worsening asthma
  • Severe dizziness or vertigo
  • Visual disturbances
  • Persistent or profuse nosebleeds

Precautions & Warnings

When using Lastin, consider the following precautions to ensure safe and effective therapy.

  • Pregnancy: consult a healthcare provider before use as safety data are limited.
  • Breastfeeding: discuss potential infant exposure with a physician.
  • Concomitant CNS depressants: monitor for additive drowsiness.
  • Pre‑existing asthma or COPD: use with caution and observe respiratory status.
  • Surgery or anesthesia: inform the anesthesiologist of antihistamine use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Azelastine may interact with other medicines; awareness of interaction severity helps guide clinical decisions.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise azelastine concentrations, increasing side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance drowsiness and sedation.
  • CNS depressants (benzodiazepines, other antihistamines): may increase sedation.
  • Other intranasal decongestants: may cause additive nasal irritation.
  • Anticholinergic drugs: may worsen dry mouth.

Frequently Asked Questions

Lastin is an intranasal antihistamine indicated for the relief of symptoms associated with allergic rhinitis, including seasonal and perennial forms. It helps reduce nasal congestion, itching, sneezing, and runny nose in patients experiencing allergy‑related nasal irritation.

Azelastine hydrochloride works by selectively blocking H1‑histamine receptors in the nasal mucosa, preventing histamine‑induced inflammation and sensory nerve activation. It also stabilises mast cells, limiting the release of additional inflammatory mediators that contribute to allergic symptoms.

The appropriate dose of Lastin is determined by a qualified healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the prescriber’s instructions and the product label for proper administration.

Safety data for azelastine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lastin.

To order Lastin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Lastin contains azelastine, a second‑generation antihistamine with both H1‑receptor antagonism and mast‑cell stabilising properties. Compared with first‑generation antihistamines, it typically causes less sedation and offers rapid symptom relief when administered intranasally.

Store Lastin at room temperature, below 25 °C, in its original packaging. Protect the spray from moisture, excessive heat and direct sunlight to maintain product stability and potency.

Lastin is administered as a nasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and spray the prescribed number of sprays while breathing in gently. The procedure is repeated in the other nostril if directed by the prescriber.

Serious adverse reactions, although rare, include anaphylaxis, angioedema, severe bronchospasm, persistent nosebleeds, and significant visual disturbances. Any signs of severe allergic reaction or respiratory difficulty should prompt immediate medical attention.

Lastin should be avoided in individuals with known hypersensitivity to azelastine or any component of the formulation. Patients with uncontrolled asthma, severe nasal obstruction, or those who have experienced serious reactions to other antihistamines should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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