Product image of Lastin (Azelastine Hydrochloride) supplied by GNH India

Lastin

Active Ingredient:
Azelastine Hydrochloride
Origin:
EU

Lastin (Azelastine Hydrochloride)

Azelastine Hydrochloride, the active ingredient in Lastin, is an antihistamine presented as an ocular formulation for eye use. It treats allergic conjunctivitis by reducing ocular itching, redness and swelling in patients with seasonal or perennial eye allergies.

GNH India supplies Lastin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Viatris As

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Indications & Clinical Uses

Lastin is an ocular antihistamine that acts on the allergic conjunctivitis pathway to relieve eye allergy symptoms.

  • Allergic conjunctivitis: alleviates itching, redness, tearing and swelling of the conjunctiva.
  • Seasonal allergic conjunctivitis: provides rapid symptom relief during pollen or allergen exposure periods.
  • Perennial allergic conjunctivitis: maintains consistent control of eye‑related allergy signs with regular use.

How It Works

  • Azelastine Hydrochloride selectively blocks histamine H1 receptors on ocular mast cells, preventing histamine‑mediated vasodilation and increased vascular permeability. By stabilising mast cells, it also inhibits the release of inflammatory mediators such as leukotrienes and prostaglandins, thereby reducing ocular inflammation and allergy symptoms.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Bitter taste after instillation.
  • Transient headache.
  • Blurred vision.
  • Mild conjunctival redness.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Corneal ulcer or epithelial defect.
  • Significant increase in intra‑ocular pressure.
  • Vision loss.
  • Persistent severe eye pain.

Precautions & Warnings

Before using Lastin, consider the following precautions:

  • Assess patient history: check for hypersensitivity to azelastine or other antihistamines.
  • Avoid use in active eye infection: postpone treatment until infection resolves.
  • Monitor for ocular irritation: discontinue if severe or persistent.
  • Caution in patients with glaucoma: evaluate intra‑ocular pressure regularly.
  • Pregnancy and lactation: use only if potential benefits justify the risk.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

When prescribing Lastin, be aware of potential drug interactions.

Major Interactions (Avoid)

  • MAO inhibitors: may increase systemic antihistamine effects.
  • Tricyclic antidepressants: risk of additive anticholinergic effects.
  • Concurrent ocular antihistamines: may cause excessive irritation.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance drowsiness.
  • Central nervous system depressants: monitor for increased sedation.
  • Other mast‑cell stabilisers: watch for additive ocular effects.

Frequently Asked Questions

Lastin is an ocular antihistamine indicated for the treatment of allergic conjunctivitis. It helps relieve eye‑related allergy symptoms such as itching, redness, tearing and swelling caused by seasonal or perennial allergens.

Azelastine blocks histamine H1 receptors on mast cells in the eye and stabilises those cells, preventing the release of histamine and other inflammatory mediators. This action reduces vasodilation, vascular permeability and the resulting allergic inflammation.

The dosing regimen for Lastin is determined by the prescribing clinician based on the patient’s condition and response. Typical practice involves one or two drops per affected eye, but the exact amount and frequency should follow the prescriber’s instructions.

Safety data for azelastine in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Lastin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Lastin contains azelastine, a selective H1‑receptor antagonist with mast‑cell stabilising properties, offering rapid symptom relief and a relatively low incidence of systemic side effects compared with some older antihistamine eye drops. Its dual action can provide more comprehensive control of allergic eye symptoms.

Store Lastin at room temperature, ideally below 25 °C, in its original packaging. Protect the container from direct light, moisture and extreme temperature fluctuations. Keep the bottle tightly closed when not in use to maintain sterility.

Lastin is applied as an eye drop. The patient should wash hands, tilt the head back slightly, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops into the conjunctival sac. Avoid touching the tip of the bottle to the eye or any surface.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis, corneal ulceration, significant increases in intra‑ocular pressure, and vision loss. Patients should seek immediate medical attention if they experience intense eye pain, sudden vision changes, or signs of a systemic allergic response.

Lastin should not be used by individuals with known hypersensitivity to azelastine, other antihistamines, or any excipients in the formulation. It is also contraindicated in patients with active ocular infections until the infection has been adequately treated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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