Product image of Latacom (Timolol Maleate, Latanoprost) supplied by GNH India

Latacom

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latacom (Timolol Maleate, Latanoprost)

Timolol maleate and latanoprost, the active ingredients in Latacom, are a beta‑adrenergic antagonist and a prostaglandin F2α analog presented as eye drops for ocular use. They are indicated for the reduction of intra‑ocular pressure in adults with open‑angle glaucoma or ocular hypertension.

GNH India supplies Latacom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for importers. Latacom is manufactured under EU GMP guidelines and distributed through a secure cold‑chain logistics network to ensure product integrity.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

  • Latacom is used to lower intra‑ocular pressure in glaucoma‑related conditions.
  • Open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers pressure to prevent conversion to glaucoma.
  • Secondary open‑angle glaucoma: helps control pressure when other therapies are insufficient.
  • Normal tension glaucoma: may be considered to achieve target pressure.

How It Works

  • Timolol maleate lowers intra‑ocular pressure by non‑selectively blocking β1 and β2 adrenergic receptors in the ciliary body, decreasing aqueous humor production. Latanoprost, a prostaglandin F2α analogue, binds to FP receptors in the iris‑ciliary body, remodeling extracellular matrix and enhancing uveoscleral outflow of aqueous humor. This dual mechanism provides a rapid and sustained pressure‑lowering effect after topical administration.

Side Effects

The most frequently reported ocular and systemic reactions to Latacom are listed below.

Common Side Effects

  • Blurred vision: temporary loss of visual clarity after instillation.
  • Eye irritation or burning: mild discomfort at the application site.
  • Redness of the conjunctiva: mild hyperemia.
  • Increased eyelash growth: longer, thicker lashes.
  • Dry eye sensation: reduced tear production.

Serious or Rare Side Effects

  • Allergic contact dermatitis: swelling, itching, or rash around the eye.
  • Severe eye pain: may indicate corneal toxicity.
  • Sudden loss of vision: urgent ophthalmic evaluation required.
  • Systemic bradycardia or hypotension: due to timolol absorption.
  • Bronchospasm: especially in patients with asthma.

Precautions & Warnings

Before prescribing Latacom, clinicians should consider the following precautions.

  • Cardiovascular assessment: timolol may cause bradycardia or lower blood pressure.
  • Respiratory status: avoid in patients with severe asthma or COPD due to beta‑blockade.
  • History of ocular surgery: monitor intra‑ocular pressure closely after procedures.
  • Known hypersensitivity: discontinue if allergic reaction occurs.
  • Pregnancy and lactation: use only if potential benefit justifies risk.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Latacom may interact with other medicines; relevant interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Systemic beta‑blockers (e.g., oral propranolol): additive bradycardia and hypotension.
  • Adrenergic agonists (e.g., epinephrine eye drops): may diminish intra‑ocular pressure reduction.
  • MAO inhibitors: increased risk of cardiovascular depression with timolol.

Moderate Interactions (Monitor Closely)

  • Other prostaglandin analogues: potential additive ocular effects.
  • Topical anesthetics: may increase corneal irritation.
  • Anticholinergic eye drops: could affect pupil size and pressure dynamics.

Frequently Asked Questions

Latacom is a combination eye‑drop formulation indicated for the reduction of intra‑ocular pressure in adults with open‑angle glaucoma or ocular hypertension. By lowering pressure, it helps to prevent optic nerve damage and preserve visual function in these conditions.

Timolol maleate blocks β‑adrenergic receptors in the ciliary body, decreasing aqueous humor production. Latanoprost activates prostaglandin F2α (FP) receptors, remodeling extracellular matrix and increasing uveoscleral outflow. The two mechanisms act together to achieve a greater and more sustained pressure‑lowering effect.

The prescribed dose of Latacom is determined by the treating ophthalmologist. Typically, one drop is instilled in each affected eye once daily, but the exact regimen, including timing and any adjustments, must be individualized by the prescriber.

Safety data for Latacom in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Latacom, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Latacom combines a beta‑blocker and a prostaglandin analogue, offering a dual mechanism that can be more effective than using either class alone. Compared with monotherapy, the combination may achieve target intra‑ocular pressure with fewer drops, potentially improving patient adherence.

Latacom should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed when not in use and retain it in the original packaging to protect the formulation from contamination.

Latacom is applied as a sterile eye drop. The patient should wash their hands, tilt the head back, pull down the lower eyelid to create a pocket, and place one drop into the conjunctival sac. The eye should be closed gently for a few seconds to aid absorption.

Serious risks include allergic reactions such as swelling or rash around the eye, sudden loss of vision, severe eye pain indicating possible corneal toxicity, systemic bradycardia or hypotension, and bronchospasm in susceptible individuals. Any of these symptoms require immediate medical attention.

Latacom is contraindicated in patients with known hypersensitivity to timolol, latanoprost, or any excipients in the formulation. It should also be avoided in individuals with severe asthma, chronic obstructive pulmonary disease, or certain cardiac conditions where beta‑blockade could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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