Product image of Latanoprost And Timolol Accord (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost And Timolol Accord

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost And Timolol Accord (Timolol Maleate, Latanoprost)

Timolol maleate and latanoprost, the active ingredients in Latanoprost And Timolol Accord, form a beta‑blocker/prostaglandin‑analog combination presented as sterile ophthalmic eye drops for ocular administration. The formulation is indicated for the reduction of intra‑ocular pressure in adults with open‑angle glaucoma or ocular hypertension, helping to preserve visual function.

GNH India supplies Latanoprost And Timolol Accord as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under strict quality‑assurance standards.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

  • Latanoprost and timolol eye drops are used to manage conditions that involve elevated intra‑ocular pressure.
  • Open‑angle glaucoma: lowers intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: reduces elevated eye pressure to prevent conversion to glaucoma.
  • Secondary ocular hypertension: decreases pressure caused by other ocular conditions.

How It Works

  • Latanoprost, a prostaglandin analog, remodels extracellular matrix in the uveoscleral pathway, enhancing aqueous humor outflow. Timolol maleate, a non‑selective beta‑adrenergic antagonist, blocks beta receptors in the ciliary epithelium, reducing aqueous humor production. The combined actions result in a net decrease in intra‑ocular pressure.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Redness of the conjunctiva.
  • Increased eyelash growth or darkening of the iris.

Serious or Rare Side Effects

  • Severe allergic reaction with swelling or rash.
  • Marked bradycardia or hypotension.
  • Bronchospasm in susceptible patients.
  • Persistent eye pain or vision loss.
  • Corneal ulceration.

Precautions & Warnings

Precautions should be observed before prescribing this combination therapy.

  • Assess cardiac status: avoid in patients with severe bradycardia or heart block.
  • Monitor respiratory function: caution in asthma or chronic obstructive pulmonary disease.
  • Check for hypersensitivity: discontinue if allergic reaction occurs.
  • Avoid concurrent systemic non‑selective beta‑blockers: may increase systemic effects.
  • Pregnancy and lactation: use only if clearly needed; safety not established.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Potential drug interactions must be reviewed.

Major Interactions (Avoid)

  • Systemic non‑selective beta‑blockers: may cause additive bradycardia.
  • Adrenergic agonists (e.g., epinephrine eye drops): may reduce ocular hypotensive effect.
  • Other prostaglandin analogs: increased risk of ocular inflammation.

Moderate Interactions (Monitor Closely)

  • Topical anesthetics: may increase corneal toxicity.
  • Anticholinergic eye drops: may affect pupil size and intra‑ocular pressure.
  • Systemic antihypertensives: monitor blood pressure for additive lowering effect.

Frequently Asked Questions

Latanoprost And Timolol Accord is a prescription eye‑drop combination used to lower intra‑ocular pressure in adults with open‑angle glaucoma or ocular hypertension, helping to prevent progression of visual field loss.

Latanoprost increases uveoscleral outflow of aqueous humor by remodeling extracellular matrix, while timolol maleate reduces aqueous humor production through non‑selective beta‑adrenergic blockade of the ciliary epithelium. Together they achieve a greater reduction in eye pressure.

The dosing regimen for Latanoprost And Timolol Accord is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. The prescriber will provide specific instructions on how many drops to instill and how often.

Safety data for the combination in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapy, the combination offers dual mechanisms—enhanced outflow and reduced production—often achieving greater pressure reduction with a single bottle, which can improve adherence versus using separate beta‑blocker and prostaglandin products.

Store the eye‑drop bottle at room temperature, preferably below 25 °C, in the original packaging. Protect it from direct light and moisture to maintain stability and potency.

The product is applied as sterile eye drops. The prescriber will instruct the patient to instill the recommended number of drops into the affected eye(s) at the specified interval, typically once daily, while avoiding contact with the tip of the bottle.

Serious risks include severe allergic reactions, marked bradycardia or hypotension, bronchospasm in patients with respiratory disease, and rare cases of corneal ulceration or vision loss. Patients should seek immediate medical attention if these symptoms occur.

Patients with known hypersensitivity to timolol, latanoprost, or any excipients, those with severe sinus bradycardia, second‑ or third‑degree heart block, uncontrolled asthma, or chronic obstructive pulmonary disease should avoid this medication unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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