Product image of Latanoprost Comp Ratiopharm (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost Comp Ratiopharm

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost Comp Ratiopharm (Timolol Maleate, Latanoprost)

Timolol maleate and latanoprost, the active ingredients in Latanoprost Comp Ratiopharm, are a beta‑blocker and a prostaglandin analog presented as eye drops for ocular use. They treat open‑angle glaucoma and ocular hypertension in adults.

GNH India supplies Latanoprost Comp Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Latanoprost Comp Ratiopharm is used to lower intra‑ocular pressure in conditions affecting the eye's drainage pathways.
  • Open‑angle glaucoma: reduces intra‑ocular pressure to prevent optic nerve damage.
  • Ocular hypertension: lowers pressure to reduce risk of progression to glaucoma.
  • Secondary open‑angle glaucoma: helps control pressure when caused by other ocular conditions.

How It Works

  • Latanoprost activates prostaglandin F (FP) receptors in the ciliary body, increasing uveoscleral outflow of aqueous humor, while timolol maleate blocks non‑selective beta‑adrenergic receptors, decreasing aqueous humor production. The combined actions result in a net reduction of intra‑ocular pressure.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Conjunctival hyperemia (eye redness).
  • Increased eyelash growth or darkening of the iris.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
  • Ocular inflammation or worsening of glaucoma.
  • Systemic bradycardia, hypotension, or asthma exacerbation.

Precautions & Warnings

  • Before initiating therapy, assess baseline intra‑ocular pressure and cardiovascular status.
  • Assess intra‑ocular pressure: ensure adequate pressure reduction.
  • Monitor heart rate and blood pressure: watch for systemic beta‑blocker effects.
  • Use with caution in asthma or COPD: beta‑blockade may provoke bronchospasm.
  • Avoid in active eye infection or severe sinusitis: may worsen condition.
  • Do not combine with other prostaglandin analog eye drops: risk of additive side effects.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Latanoprost Comp Ratiopharm may interact with several systemic and ocular agents.

Major Interactions (Avoid)

  • Systemic non‑selective beta‑blockers (e.g., propranolol): increased risk of bradycardia.
  • Other prostaglandin analog eye drops: additive ocular side effects.
  • Sympathomimetic ophthalmic agents: may reduce efficacy of timolol.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: possible alteration of ocular blood flow.
  • Topical NSAIDs: may increase ocular irritation.
  • Anticholinergic eye drops: monitor for changes in pupil size and pressure control.

Frequently Asked Questions

Latanoprost Comp Ratiopharm is a prescription eye‑drop combination containing timolol maleate and latanoprost. It is used to lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension, helping to prevent optic nerve damage and preserve vision.

Timolol maleate is a non‑selective beta‑adrenergic blocker. By blocking beta receptors in the ciliary body, it reduces the production of aqueous humor, which contributes to a decrease in intra‑ocular pressure.

The dosing regimen for Latanoprost Comp Ratiopharm is determined by the prescribing ophthalmologist based on the individual patient's condition, response, and tolerance. Patients should follow the prescriber’s instructions exactly.

Safety data for use during pregnancy or lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The combination provides dual mechanisms—timolol reduces aqueous humor production while latanoprost enhances outflow—offering greater intra‑ocular pressure reduction than either agent alone. This can simplify therapy by using a single bottle instead of two separate eye drops.

Store the eye‑drop bottles at room temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct light, and discard any product that appears discolored or cloudy.

The medication is applied as one drop into the affected eye(s) once daily, usually in the evening, unless otherwise directed by the prescriber. Patients should avoid touching the tip of the bottle to the eye or any other surface.

Serious risks include severe allergic reactions, marked reduction in heart rate or blood pressure, bronchospasm in patients with asthma or COPD, and worsening of glaucoma if the drug is not tolerated. Any of these symptoms require immediate medical attention.

Patients with known hypersensitivity to timolol, latanoprost, or any excipients in the formulation should avoid this product. It is also contraindicated in individuals with severe sinusitis, active ocular infections, or those who cannot tolerate beta‑blockers due to cardiac or respiratory conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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