Product image of Latanoprost Sifi (Latanoprost) supplied by GNH India

Latanoprost Sifi

Active Ingredient:
Latanoprost
Origin:
EU

Latanoprost Sifi (Latanoprost)

Latanoprost, the active ingredient in Latanoprost Sifi, is a prostaglandin analog presented as eye drops for ocular use. It lowers intraocular pressure in adults with primary open-angle glaucoma or ocular hypertension, helping to preserve visual function. It is indicated for patients who require long‑term management of elevated eye pressure to prevent optic nerve damage.

GNH India supplies Latanoprost Sifi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global logistics for regulated eye‑care products.

Manufacturer / TM Owner

Sifi S.P.A.

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Indications & Clinical Uses

Latanoprost is a prostaglandin analog used to lower intraocular pressure in glaucoma and ocular hypertension.

  • Primary open-angle glaucoma: reduces intraocular pressure to slow disease progression.
  • Ocular hypertension: lowers eye pressure to prevent conversion to glaucoma.
  • Secondary open-angle glaucoma: helps control pressure when other therapies are insufficient.
  • Pseudoexfoliative glaucoma: decreases pressure to protect the optic nerve.

How It Works

  • Latanoprost binds to prostaglandin F‑type (FP) receptors on the ciliary muscle and scleral tissue, activating the phosphatidylinositol‑calcium signaling cascade. This leads to remodeling of the extracellular matrix and increased uveoscleral outflow of aqueous humor, thereby reducing intraocular pressure. The drug’s high affinity for the FP receptor ensures selective action with minimal systemic absorption, and the pharmacodynamic response typically begins within hours after instillation.

Side Effects

Latanoprost may cause ocular and systemic reactions; reported events are categorized by frequency.

Common Side Effects

  • Eye redness: mild conjunctival hyperemia after drop instillation.
  • Increased eyelash length: growth of longer, thicker lashes.
  • Iris pigmentation change: gradual darkening of the iris color.
  • Eye irritation: transient burning or stinging sensation.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or difficulty breathing.
  • Uveitis: inflammation of the uveal tract that may impair vision.
  • Macular edema: swelling of the central retina that can reduce visual acuity.

Precautions & Warnings

When prescribing Latanoprost, clinicians should consider several safety precautions to minimize risks.

  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Breastfeeding: insufficient data; consider alternatives.
  • Intraocular pressure monitoring: check pressure after starting therapy.
  • Ocular infection: do not use if active eye infection is present.
  • Contact lenses: remove lenses before instilling drops and wait before reinserting.
  • Store at room temperature: keep bottle in original container, protect from light and moisture.

Avoid Interactions

Latanoprost can interact with other ophthalmic or systemic agents; awareness of these interactions helps avoid reduced efficacy or increased adverse effects.

Major Interactions (Avoid)

  • Nonsteroidal anti‑inflammatory eye drops: may diminish Latanoprost's IOP‑lowering effect.
  • Systemic prostaglandin analogs: can increase risk of ocular side effects.
  • Anticholinergic eye drops: may reduce therapeutic efficacy.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops: additive intraocular pressure reduction may require monitoring.
  • Carbonic anhydrase inhibitor eye drops: may increase ocular irritation.
  • Corticosteroid eye drops: potential heightened risk of cataract formation.

Frequently Asked Questions

Latanoprost Sifi is prescribed to lower intraocular pressure in adults with primary open‑angle glaucoma or ocular hypertension. By reducing eye pressure, it helps prevent optic nerve damage and preserves visual function in patients at risk of glaucoma progression.

Latanoprost binds to prostaglandin F‑type (FP) receptors in the eye, triggering a cascade that remodels extracellular matrix and enhances uveoscleral outflow of aqueous humor. This increased drainage lowers intraocular pressure, which is the primary therapeutic goal in glaucoma management.

The prescribed dose is determined by the treating ophthalmologist. Typically, one drop is instilled into the affected eye(s) once daily in the evening, but the exact regimen may be adjusted based on individual response and clinical judgment.

Safety data for Latanoprost in pregnancy and lactation are limited. It is classified as pregnancy category unknown, so it should be used only if the potential benefit justifies the potential risk to the fetus. Caution is also advised for nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Latanoprost, a prostaglandin analog, is often preferred for its once‑daily dosing and strong intraocular pressure‑lowering effect. Compared with beta‑blockers such as timolol, it has a different side‑effect profile, typically causing fewer systemic effects but more ocular changes like iris darkening.

Latanoprost Sifi should be stored at room temperature, below 25 °C, in its original container. Protect the bottle from light and moisture, keep the cap tightly closed, and discard any solution that appears discolored or cloudy.

Instill one drop of Latanoprost Sifi into the conjunctival sac of each prescribed eye, preferably in the evening. Avoid touching the dropper tip to the eye or any surface, wash hands before and after use, and follow any additional instructions from the eye‑care professional.

While uncommon, serious adverse events include severe allergic reactions (e.g., swelling, rash, breathing difficulty), uveitis (inflammation of the uveal tract), and macular edema (central retinal swelling that can impair vision). Patients should seek immediate medical attention if these symptoms occur.

Latanoprost Sifi should be avoided in individuals with known hypersensitivity to latanoprost or any component of the formulation, and in patients with active ocular infections or inflammation. Caution is also advised for those with a history of severe ocular inflammation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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