Product image of Latanoprost/Timolol Aurobindo (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost/Timolol Aurobindo

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost/Timolol Aurobindo (Timolol Maleate, Latanoprost)

Timolol maleate and latanoprost, the active ingredients in Latanoprost/Timolol Aurobindo, are a beta‑blocker/prostaglandin analog combination presented as an ophthalmic solution for ocular use. It treats open‑angle glaucoma and ocular hypertension in adults.

GNH India supplies Latanoprost/Timolol Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across EU and other global markets. The company adheres to stringent quality standards and provides regulatory support for importation. Customers benefit from reliable logistics, batch traceability, and responsive technical assistance throughout the supply chain.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Latanoprost/Timolol is indicated for ocular conditions where reduction of intra‑ocular pressure is required, primarily within the glaucoma therapeutic pathway.

  • Open‑angle glaucoma: lowers intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: reduces elevated eye pressure to prevent conversion to glaucoma.
  • Secondary ocular hypertension: helps control pressure when caused by other ocular conditions.
  • Mixed‑mechanism glaucoma: provides dual action to achieve target pressure when monotherapy is insufficient.

How It Works

  • Latanoprost, a prostaglandin F2α analogue, binds to FP receptors in the ciliary body, enhancing uveoscleral outflow of aqueous humour. Timolol maleate, a non‑selective β‑adrenergic antagonist, blocks β1 and β2 receptors in the ciliary epithelium, decreasing aqueous humour production. This dual mechanism provides complementary pressure‑lowering action suitable for patients requiring more than one therapeutic pathway.

Side Effects

Adverse reactions to Latanoprost/Timolol may involve ocular and systemic manifestations, varying in frequency and severity.

Common Side Effects

  • Eye irritation: transient burning or stinging after instillation.
  • Blurred vision: temporary visual disturbance.
  • Conjunctival hyperemia: redness of the eye.
  • Dry eye: decreased tear production.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or difficulty breathing.
  • Persistent eye pain: may indicate corneal involvement.

Precautions & Warnings

When prescribing Latanoprost/Timolol, clinicians should consider several precautionary measures to ensure safe and effective use.

  • Assess cardiovascular status: avoid in patients with severe bradycardia or heart block.
  • Evaluate respiratory conditions: use with caution in asthma or chronic obstructive pulmonary disease.
  • Monitor intra‑ocular pressure: check response and adjust therapy as needed.
  • Consider ocular surface disease: patients with severe dry eye may experience discomfort.
  • Pregnancy and lactation: safety not established; weigh potential benefits against risks.
  • Store at ambient temperature: keep the bottle in its original container, protect from light and moisture.

Avoid Interactions

Latanoprost/Timolol may interact with other medicines, altering its efficacy or increasing adverse effects.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers (e.g., propranolol): additive systemic beta‑blockade may cause bradycardia or hypotension.
  • Other ocular hypotensive agents: excessive IOP reduction can lead to ocular hypotony.

Moderate Interactions (Monitor Closely)

  • Systemic beta‑blockers: monitor heart rate and blood pressure.
  • Calcium channel blockers: may enhance ocular hypotensive effect.
  • Anticholinergic eye drops: could affect pupil size and drug absorption.

Frequently Asked Questions

Latanoprost/Timolol is an ophthalmic combination indicated for the management of open‑angle glaucoma and ocular hypertension. By lowering intra‑ocular pressure, it helps to prevent optic nerve damage and preserve visual field in patients diagnosed with these conditions.

Timolol maleate is a non‑selective β‑adrenergic blocker that reduces aqueous humour production by inhibiting β1 and β2 receptors in the ciliary epithelium. This decrease in fluid formation contributes to the overall reduction of intra‑ocular pressure when combined with latanoprost.

The prescribed dose is determined by the treating ophthalmologist. In clinical practice the product is typically administered as one drop in the affected eye(s) once daily, but the exact regimen should follow the prescriber’s instructions and the patient’s response.

Safety data for Latanoprost/Timolol in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the prescribing clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapy, the combination offers dual mechanisms—enhanced outflow from latanoprost and reduced production from timolol—resulting in greater intra‑ocular pressure reduction. This can be advantageous for patients who do not achieve target pressure with monotherapy alone.

Store the bottle at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from direct light and moisture. Do not freeze the solution, and keep the container tightly closed when not in use.

The medication is applied as a sterile ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and place one drop into the eye. Close the eye gently for a few seconds and avoid blinking excessively.

Serious adverse events include severe allergic reactions such as swelling, rash or breathing difficulty, and persistent eye pain that may signal corneal involvement. Systemic effects like marked bradycardia or bronchospasm can also occur, especially in patients with underlying cardiac or respiratory disease.

The product is contraindicated in patients with known hypersensitivity to either component, severe sinusitis, active ocular infections, advanced heart block, severe bradycardia, or uncontrolled asthma/COPD. It should also be avoided in individuals with a history of intra‑ocular inflammation that could be worsened by prostaglandin analogues.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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