Product image of Latanoprost/Timolol Biogaran (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost/Timolol Biogaran

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost/Timolol Biogaran (Timolol Maleate, Latanoprost)

Latanoprost and Timolol, the active ingredients in Latanoprost/Timolol Biogaran, are a prostaglandin analog and a beta‑blocker presented as eye drops for ocular (topical) use. They treat open‑angle glaucoma and ocular hypertension in adults.

GNH India supplies Latanoprost/Timolol Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

  • Latanoprost/Timolol is a combination antiglaucoma therapy that reduces intraocular pressure by affecting aqueous humor dynamics.
  • Open-angle glaucoma: lowers intraocular pressure to prevent optic nerve damage.
  • Ocular hypertension: reduces elevated eye pressure to lower the risk of developing glaucoma.

How It Works

  • Latanoprost binds to FP receptors in the ciliary body, increasing uveoscleral outflow of aqueous humor, while Timolol blocks beta‑adrenergic receptors in the ciliary epithelium, decreasing aqueous humor production. The dual action results in a net reduction of intraocular pressure.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Increased pigmentation of the iris or eyelash growth.
  • Conjunctival hyperemia (red eye).
  • Mild ocular discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, urticaria).
  • Bronchospasm or worsening asthma.
  • Marked bradycardia or hypotension.
  • Corneal edema or keratitis.
  • Systemic beta‑blocker effects such as fatigue or dizziness.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Cardiac history: avoid in patients with severe bradycardia or heart block.
  • Respiratory status: use cautiously in asthma or COPD.
  • Hypersensitivity: discontinue if allergic eye reaction occurs.
  • Concomitant beta‑blockers: avoid using additional systemic or ocular beta‑blockers.
  • Pregnancy and lactation: prescribe only if benefit outweighs potential risk.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Latanoprost/Timolol may interact with other medicines as follows:

Major Interactions (Avoid)

  • Systemic non‑selective beta‑blockers: additive bradycardia or hypotension.
  • Calcium channel blockers: increased risk of cardiac conduction effects.
  • Other prostaglandin analog eye drops: heightened ocular irritation.

Moderate Interactions (Monitor Closely)

  • Anticholinergic ophthalmic agents: may affect pupil size and intraocular pressure.
  • Systemic antihypertensives: monitor blood pressure for additive lowering.
  • Inhaled beta‑agonists: possible reduction of bronchodilator efficacy.

Frequently Asked Questions

Latanoprost/Timolol Biogaran is a prescription ophthalmic solution indicated for the management of elevated intraocular pressure in patients with open‑angle glaucoma or ocular hypertension. Reducing pressure helps prevent optic nerve damage and progressive visual field loss.

Latanoprost is a prostaglandin F2α analog that binds to FP receptors in the ciliary body, enhancing uveoscleral outflow of aqueous humor. This increased outflow lowers intraocular pressure, contributing to glaucoma control.

Timolol is a non‑selective beta‑adrenergic antagonist that blocks beta‑receptors in the ciliary epithelium, reducing the production of aqueous humor. The decrease in fluid formation further lowers intraocular pressure.

The dosing regimen is set by the prescribing clinician. Typically, one drop is instilled in each affected eye once daily, often in the evening, but exact instructions must follow the prescriber’s order.

Safety data are limited and the product is classified as pregnancy category unknown. It should be used during pregnancy or lactation only when the potential benefit justifies the potential risk and under close medical supervision.

Enquiries are submitted via the product page on gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

The main alternative is using either a prostaglandin analog or a beta‑blocker alone. The combination offers dual mechanisms in a single bottle, often achieving greater intraocular pressure reduction than monotherapy and simplifying the treatment regimen for patients.

Store the eye‑drop bottles at room temperature, below 25 °C, in the original packaging. Protect from light and moisture, and keep the cap tightly closed to maintain sterility and product integrity.

The solution is applied topically to the conjunctival sac. After washing hands, tilt the head back, pull down the lower eyelid, instill one drop into the eye, then close the eye gently for a few minutes, avoiding contact between the bottle tip and the eye.

Serious adverse events include severe allergic reactions, bronchospasm in asthmatic patients, marked bradycardia, hypotension, and corneal edema. Patients should seek immediate medical attention if they experience difficulty breathing, rapid heartbeat, vision changes, or eye pain.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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