Product image of Latanoprost/Timolol Blumont Pharma (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost/Timolol Blumont Pharma

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost/Timolol Blumont Pharma (Timolol Maleate, Latanoprost)

Latanoprost and Timolol Maleate, the active ingredients in Latanoprost/Timolol Blumont Pharma, are a prostaglandin analog/beta‑blocker combination presented as an ophthalmic solution for ocular use. It treats primary open‑angle glaucoma and ocular hypertension by lowering intra‑ocular pressure.
GNH India supplies Latanoprost/Timolol Blumont Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution aligned to EU regulatory standards.

Manufacturer / TM Owner

Blumont Pharma Ltd

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Indications & Clinical Uses

  • Latanoprost/Timolol is used in the management of ocular pressure disorders, primarily glaucoma and ocular hypertension.
  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow optic nerve damage.
  • Ocular hypertension: lowers elevated eye pressure to prevent progression to glaucoma.
  • Secondary open‑angle glaucoma: assists in pressure control when monotherapy is insufficient.

How It Works

  • Latanoprost, a prostaglandin F‑type receptor agonist, increases uveoscleral outflow of aqueous humor, while timolol, a non‑selective β‑adrenergic antagonist, decreases aqueous humor production by blocking β‑receptors in the ciliary epithelium. The combined actions produce an additive reduction in intra‑ocular pressure and support once‑daily dosing.

Side Effects

Adverse reactions to the Latanoprost/Timolol ophthalmic solution can involve the eye surface, systemic effects, or rare severe events.

Common Side Effects

  • Eye irritation: transient burning or stinging after instillation.
  • Conjunctival hyperemia: mild redness of the eye.
  • Eyelash changes: increased length or thickness.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or anaphylaxis.
  • Persistent ocular inflammation: uveitis or keratitis.
  • Systemic bradycardia or bronchospasm: due to timolol absorption.

Precautions & Warnings

Before prescribing Latanoprost/Timolol, clinicians should consider several safety and handling precautions.

  • Contraindication: active ocular infection or inflammation.
  • Caution: patients with asthma or chronic obstructive pulmonary disease.
  • Monitor: heart rate and blood pressure in patients with cardiac disease.
  • Avoid: use in patients with known hypersensitivity to prostaglandin analogues or beta‑blockers.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep the bottle in the original packaging, protect from light and moisture.

Avoid Interactions

Latanoprost/Timolol may interact with other medications that affect intra‑ocular pressure or systemic beta‑adrenergic activity.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers (e.g., propranolol): additive systemic β‑blockade leading to bradycardia.
  • Carbonic anhydrase inhibitors (e.g., acetazolamide): excessive intra‑ocular pressure reduction.
  • Sympathomimetic agents (e.g., epinephrine eye drops): antagonized ocular hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: may reduce efficacy of timolol.
  • Systemic steroids: may diminish prostaglandin response.
  • MAO inhibitors: potential for altered timolol metabolism.

Frequently Asked Questions

Latanoprost/Timolol is indicated for the reduction of intra‑ocular pressure in patients with primary open‑angle glaucoma and ocular hypertension. By lowering eye pressure, it helps to prevent optic nerve damage and preserve visual function.

The combination contains latanoprost, which activates prostaglandin F receptors to increase uveoscleral outflow of aqueous humor, and timolol, a non‑selective β‑blocker that reduces aqueous humor production by blocking β‑adrenergic receptors in the ciliary epithelium. Together they produce a greater pressure‑lowering effect than either component alone.

The prescribed dose is determined by the treating ophthalmologist. Typically, one drop is instilled in the affected eye(s) once daily in the evening, but the exact regimen should follow the clinician’s instructions and may be adjusted based on individual response.

Safety data in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with single‑agent therapy, the fixed‑dose combination offers additive intra‑ocular pressure reduction, often achieving target pressures with a single daily drop. This can improve adherence and reduce exposure to multiple preservatives, while providing comparable safety to each component used alone.

Store the ophthalmic solution at ambient temperature, away from direct sunlight and moisture. Keep the bottle tightly closed in its original packaging until use. Do not freeze the product, and discard any solution that appears discolored or contains particles.

The medication is applied topically to the eye. Tilt the head back, pull down the lower eyelid to create a small pocket, and place one drop into the conjunctival sac. Close the eye gently for a few seconds, avoid blinking excessively, and do not touch the tip of the bottle to the eye or any surface.

Serious adverse events, although rare, include severe allergic reactions (e.g., anaphylaxis), persistent ocular inflammation such as uveitis or keratitis, and systemic effects like marked bradycardia or bronchospasm, especially in patients with underlying respiratory or cardiac disease.

Patients with active ocular infections or inflammation, known hypersensitivity to prostaglandin analogues or beta‑blockers, and individuals with severe asthma, chronic obstructive pulmonary disease, or certain cardiac conduction disorders should avoid this medication unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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