Product image of Latanoprost/Timolol Elvim (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost/Timolol Elvim

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost/Timolol Elvim (Timolol Maleate, Latanoprost)

Timolol maleate and Latanoprost, the active ingredients in Latanoprost/Timolol Elvim, are a beta‑blocker and a prostaglandin analog presented as an ophthalmic solution for ocular use. They lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension.

GNH India supplies Latanoprost/Timolol Elvim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sia Elvim

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Indications & Clinical Uses

Latanoprost/Timolol Elvim is used in the management of glaucoma‑related conditions to reduce intra‑ocular pressure.

  • Open‑angle glaucoma: lowers eye pressure to prevent optic nerve damage.
  • Ocular hypertension: reduces elevated eye pressure and lowers risk of progression to glaucoma.
  • Secondary open‑angle glaucoma: provides pressure‑lowering effect similar to primary disease.

How It Works

  • Latanoprost increases uveoscleral outflow of aqueous humor by activating prostaglandin F receptors in the ciliary muscle, while timolol maleate non‑selectively blocks beta‑adrenergic receptors in the ciliary body, decreasing aqueous humor production. The combined actions result in a net reduction of intra‑ocular pressure.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Conjunctival hyperemia (red eye).
  • Itching or mild allergic‑type reaction on the eyelid.
  • Dry eye or foreign‑body sensation.
  • Increased eyelash growth.

Serious or Rare Side Effects

  • Severe ocular pain or sudden vision loss.
  • Allergic angioedema affecting the eye or periorbital tissues.
  • Systemic bradycardia, hypotension, or exacerbation of asthma.
  • Corneal ulceration or keratitis.
  • Persistent intra‑ocular pressure rise despite therapy.

Precautions & Warnings

Before prescribing Latanoprost/Timolol Elvim, clinicians should consider several safety factors.

  • Cardiovascular assessment: monitor heart rate and blood pressure due to beta‑blocker effects.
  • Respiratory status: avoid in patients with asthma or severe COPD.
  • Intra‑ocular pressure monitoring: ensure adequate pressure reduction and watch for hypotony.
  • Sulfonamide allergy: check for hypersensitivity to preservative components.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Latanoprost/Timolol Elvim may interact with other medicines; awareness helps prevent adverse outcomes. Major Interactions (Avoid):\n- Systemic non‑selective beta‑blockers (e.g., propranolol): additive bradycardia and hypotension.

  • Topical ocular beta‑blockers: increased systemic beta‑blockade risk.
  • Systemic adrenergic agonists (e.g., epinephrine): may diminish intra‑ocular pressure‑lowering effect.
  • Carbonic anhydrase inhibitors (oral or topical): excessive IOP reduction leading to hypotony.

Moderate Interactions (Monitor Closely)

  • Inhaled beta‑agonists (e.g., albuterol): may reduce ocular beta‑blocker efficacy.
  • Anticholinergic eye drops: potential ocular surface irritation.
  • Topical NSAIDs: heightened risk of corneal complications.
  • Calcium channel blockers: possible additive cardiovascular effects.

Frequently Asked Questions

Latanoprost/Timolol Elvim is an ophthalmic solution indicated for the reduction of intra‑ocular pressure in patients with open‑angle glaucoma and ocular hypertension. By lowering eye pressure, it helps prevent optic nerve damage and progression of visual field loss associated with these conditions.

The drug combines two mechanisms: latanoprost, a prostaglandin analog, enhances uveoscleral outflow of aqueous humor, while timolol, a non‑selective beta‑blocker, reduces aqueous humor production by blocking beta‑adrenergic receptors in the ciliary body. Together they provide a greater overall reduction in intra‑ocular pressure than either agent alone.

The prescribed dosing regimen is determined by the treating ophthalmologist based on the individual patient's condition, response, and tolerance. Typically, one drop is instilled into the affected eye(s) once daily, but the exact dose and timing should follow the prescriber’s instructions.

Safety data for use in pregnancy and lactation are limited. The product should be used only if the potential therapeutic benefit justifies any potential risk to the fetus or infant. Physicians should discuss the risk‑benefit profile with the patient before initiating therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with monotherapy agents, the fixed‑dose combination offers the convenience of a single drop and synergistic pressure‑lowering effects. It often achieves greater IOP reduction than either latanoprost or timolol alone and may reduce the need for additional medications, improving adherence.

The ophthalmic solution should be stored at room temperature, below 25 °C, in its original container. Protect the bottle from light and moisture, and keep the cap tightly closed when not in use. Do not freeze the product.

The medication is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a small pocket, and place one drop into the conjunctival sac. Close the eye gently for a few seconds and avoid blinking excessively.

Serious risks include severe ocular pain, sudden vision loss, corneal ulceration, systemic bradycardia or hypotension, and exacerbation of asthma or chronic obstructive pulmonary disease. Any of these symptoms require immediate medical attention.

Patients with known hypersensitivity to timolol, latanoprost, or any excipients in the formulation should avoid the product. It is also contraindicated in individuals with severe bronchial asthma, chronic obstructive pulmonary disease, sinus bradycardia, or second‑ or third‑degree atrioventricular block unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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