Product image of Latanoprost + Timolol Generis (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost + Timolol Generis

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost + Timolol Generis (Timolol Maleate, Latanoprost)

Timolol maleate and Latanoprost, the active ingredients in Latanoprost + Timolol Generis, are a non‑selective beta‑blocker and a prostaglandin analog presented as a combination eye‑drop formulation for ocular (topical) use. The product is indicated for the management of open‑angle glaucoma and ocular hypertension by lowering intra‑ocular pressure.

GNH India supplies Latanoprost + Timolol Generis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Latanoprost + Timolol Generis is used in the ophthalmic therapeutic area to lower intra‑ocular pressure in glaucoma‑related conditions.

  • Open‑angle glaucoma: reduces intra‑ocular pressure, helping to prevent optic nerve damage.
  • Ocular hypertension: lowers elevated eye pressure to reduce risk of progression to glaucoma.
  • Other forms of glaucoma where pressure reduction is required: provides IOP control as part of a comprehensive treatment plan.

How It Works

  • Latanoprost, a prostaglandin F2α analog, binds to FP receptors in the ciliary body, enhancing uveoscleral outflow of aqueous humor. Timolol maleate, a non‑selective β‑adrenergic antagonist, blocks β1 and β2 receptors in the ciliary epithelium, decreasing aqueous humor production. The combined actions result in a synergistic reduction of intra‑ocular pressure.

Side Effects

Latanoprost + Timolol Generis may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Conjunctival hyperemia (eye redness).
  • Increased eyelash growth or darkening of the iris.

Serious or Rare Side Effects

  • Severe allergic reaction with swelling of the eyelids or face.
  • Exacerbation of asthma or chronic obstructive pulmonary disease.
  • Marked bradycardia or hypotension.
  • Vision loss due to ocular inflammation.

Precautions & Warnings

Before prescribing Latanoprost + Timolol Generis, clinicians should consider several safety precautions.

  • Cardiovascular assessment: evaluate heart rate and blood pressure due to beta‑blocker effects.
  • Respiratory evaluation: avoid in patients with asthma or severe COPD.
  • Diabetes monitoring: beta‑blockers may mask hypoglycaemia symptoms.
  • Pregnancy and lactation: use only if potential benefit outweighs risk, as safety data are limited.
  • Concomitant ocular surgery: discontinue before procedures to reduce risk of delayed wound healing.
  • Store at room temperature: keep bottle tightly closed, protect from light and moisture.

Avoid Interactions

Latanoprost + Timolol Generis can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Systemic non‑selective beta‑blockers: additive bradycardia and hypotension.
  • Sympathomimetic eye drops (e.g., epinephrine): may reduce efficacy of timolol.
  • Antihypertensive agents (e.g., calcium channel blockers): increased risk of low blood pressure.

Moderate Interactions (Monitor Closely)

  • Carbonic anhydrase inhibitors (e.g., dorzolamide): potential additive IOP‑lowering effect.
  • Topical corticosteroids: may increase intra‑ocular pressure despite treatment.
  • NSAID eye drops: possible irritation when combined.
  • Anticholinergic drugs: may affect pupil size and ocular dynamics.

Frequently Asked Questions

Latanoprost + Timolol Generis is a prescription eye‑drop combination used to lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension, helping to protect the optic nerve and preserve vision.

Timolol maleate blocks β‑adrenergic receptors in the eye, reducing aqueous humor production, while Latanoprost increases uveoscleral outflow of fluid. Together they provide a synergistic reduction of intra‑ocular pressure.

The dosing regimen is determined by the prescribing clinician based on the individual patient's condition and response. Typically, one drop is instilled in the affected eye(s) once daily, but the exact schedule should follow the prescriber’s instructions.

Safety data for use in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑agent therapy, the combination offers dual mechanisms—decreased production and increased outflow—resulting in greater IOP reduction. It may be preferred when monotherapy does not achieve target pressure, but individual patient factors and tolerability guide the choice.

Store the eye‑drop bottle at room temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect it from light and moisture, and discard any solution that appears discoloured or contaminated.

The medication is applied topically to the eye. After washing hands, tilt the head back, pull down the lower eyelid to form a pocket, and place one drop into the conjunctival sac. Close the eye gently and avoid blinking excessively for a few seconds.

Serious adverse events, although rare, include severe allergic reactions, marked bradycardia or hypotension, exacerbation of asthma or COPD, and vision loss due to ocular inflammation. Patients should seek immediate medical attention if any of these symptoms occur.

The product is contraindicated in patients with known hypersensitivity to either component, severe sinus node dysfunction, uncontrolled asthma or severe chronic obstructive pulmonary disease, and in individuals taking systemic non‑selective beta‑blockers without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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