Product image of Latanoprost/Timolol Pharmathen (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost/Timolol Pharmathen

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost/Timolol Pharmathen (Timolol Maleate, Latanoprost)

Timolol maleate and Latanoprost, the active ingredients in Latanoprost/Timolol Pharmathen, are a beta‑blocker and a prostaglandin analog presented as an ophthalmic solution for ocular use. They are indicated for the reduction of intra‑ocular pressure in glaucoma and ocular hypertension patients.

GNH India supplies Latanoprost/Timolol Pharmathen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

  • Latanoprost/Timolol Pharmathen is used in the management of ocular conditions that require lowering of intra‑ocular pressure.
  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers pressure to prevent conversion to glaucoma.
  • Glaucoma (any type): provides combined mechanism to control pressure when monotherapy is insufficient.

How It Works

  • Latanoprost activates prostaglandin F receptors in the ciliary body, increasing uveoscleral outflow of aqueous humor. Timolol maleate blocks non‑selective β‑adrenergic receptors in the ciliary epithelium, decreasing aqueous humor production. The combined actions result in a net reduction of intra‑ocular pressure.

Side Effects

Latanoprost/Timolol Pharmathen may cause ocular and systemic reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Conjunctival hyperemia (red eye).
  • Darkening of the iris or peri‑ocular skin.
  • Increased eyelash growth.
  • Foreign body sensation.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
  • Persistent eye pain or inflammation.
  • Sudden loss of vision.
  • Corneal ulceration or keratitis.
  • Systemic bradycardia or hypotension.
  • Respiratory distress in susceptible patients.

Precautions & Warnings

  • Before prescribing Latanoprost/Timolol Pharmathen, clinicians should consider patient‑specific factors.
  • Assess cardiac status: avoid in patients with severe bradycardia or heart block.
  • Monitor respiratory disease: use with caution in asthma or COPD.
  • Avoid in sinus node dysfunction: contraindicated in patients with sick sinus syndrome.
  • Check for hypersensitivity: discontinue if allergic reactions occur.
  • Evaluate systemic beta‑blocker use: consider additive effects on heart rate and blood pressure.
  • Store at room temperature: keep bottle tightly closed, protect from light and moisture.

Avoid Interactions

Latanoprost/Timolol Pharmathen can interact with other systemic or ocular agents.

Major Interactions (Avoid)

  • Systemic non‑selective beta‑blockers: may cause excessive bradycardia or hypotension.
  • Other intra‑ocular pressure‑lowering agents (e.g., pilocarpine) used concurrently: risk of additive ocular effects.
  • Anti‑arrhythmic drugs (e.g., propranolol): increased risk of cardiac depression.

Moderate Interactions (Monitor Closely)

  • Antihypertensive medications: monitor blood pressure for additive lowering.
  • Asthma or COPD treatments: watch for bronchospasm exacerbation.
  • NSAIDs or corticosteroid eye drops: may affect ocular surface tolerance.
  • MAO inhibitors: observe for potential cardiovascular changes.

Frequently Asked Questions

Latanoprost/Timolol Pharmathen is a prescription ophthalmic solution indicated to lower intra‑ocular pressure in patients with primary open‑angle glaucoma and ocular hypertension. By reducing pressure, it helps to prevent optic nerve damage and preserve visual function.

Timolol maleate is a non‑selective beta‑adrenergic blocker that reduces the production of aqueous humor by inhibiting β‑receptors in the ciliary body. This decrease in fluid formation contributes to lower intra‑ocular pressure when combined with Latanoprost.

The dosing regimen for Latanoprost/Timolol Pharmathen is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Typically, one drop is instilled into the affected eye(s) once daily, but the exact schedule should follow the prescriber’s instructions.

Safety data for Latanoprost/Timolol in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Latanoprost alone increases uveoscleral outflow, while the combination adds Timolol’s reduction of aqueous humor production. This dual mechanism often provides greater intra‑ocular pressure reduction than Latanoprost monotherapy, especially in patients who need additional pressure control.

Latanoprost/Timolol Pharmathen should be stored at room temperature, protected from light and moisture. Keep the bottle tightly closed when not in use and store it in its original packaging to maintain stability.

The medication is administered as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a pocket, and place one drop into the conjunctival sac. Close the eye gently and avoid blinking excessively.

Serious risks include severe allergic reactions, sudden loss of vision, corneal ulceration, and systemic effects such as marked bradycardia or hypotension. Patients should seek immediate medical attention if they experience any of these symptoms.

The product is contraindicated in patients with known hypersensitivity to either component, those with sinus node dysfunction, severe bradycardia, or advanced heart block, and individuals with active respiratory conditions such as uncontrolled asthma where beta‑blockade could worsen symptoms.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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