Product image of Latanoprost/Timolol Upjohn (Timolol Maleate, Latanoprost) supplied by GNH India

Latanoprost/Timolol Upjohn

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latanoprost/Timolol Upjohn (Timolol Maleate, Latanoprost)

Latanoprost and Timolol, the active ingredients in Latanoprost/Timolol Upjohn, are a prostaglandin analog and a beta‑blocker presented as an ophthalmic solution for ocular use. It treats open‑angle glaucoma and ocular hypertension in adult patients.
GNH India supplies Latanoprost/Timolol Upjohn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Upjohn Eesv

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Indications & Clinical Uses

Latanoprost/Timolol is indicated for conditions affecting intraocular pressure within the glaucoma disease family.

  • Open‑angle glaucoma: lowers intraocular pressure to prevent optic‑nerve damage.
  • Ocular hypertension: reduces elevated eye pressure to normal levels.
  • Primary open‑angle glaucoma: maintains target pressure to preserve visual field.

How It Works

  • Latanoprost increases uveoscleral outflow of aqueous humor by activating prostaglandin F receptors, while Timolol blocks beta‑adrenergic receptors in the ciliary body, decreasing aqueous humor production. The combined actions result in a greater reduction of intraocular pressure than either component alone.

Side Effects

Latanoprost/Timolol may cause ocular and systemic reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Blurred vision shortly after instillation.
  • Conjunctival hyperemia (red eye).
  • Eyelash growth or darkening.
  • Mild headache.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., swelling, rash).
  • Significant decrease in heart rate or bronchospasm in susceptible individuals.
  • Persistent eye pain or vision loss.
  • Periorbital fat atrophy with long‑term use.

Precautions & Warnings

Before using Latanoprost/Timolol, consider the following safety measures.

  • Cardiovascular disease: assess heart rate and blood pressure.
  • Respiratory conditions: avoid in patients with asthma or COPD.
  • Pregnancy and lactation: use only if benefit outweighs risk.
  • Contact lens wearers: remove lenses before instillation and wait 15 minutes before reinserting.
  • Concomitant ocular surgery: discontinue prior to procedure as advised by surgeon.

Store at below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Latanoprost/Timolol can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers (systemic): may cause additive bradycardia or bronchospasm.
  • MAO inhibitors: can enhance ocular hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Other intraocular pressure‑lowering agents: may increase risk of excessive pressure reduction.
  • Anticholinergic eye drops: could diminish therapeutic effect.
  • Systemic antihypertensives: monitor blood pressure for additive lowering.

Frequently Asked Questions

Latanoprost/Timolol is a prescription ophthalmic solution used to lower intraocular pressure in adults with open‑angle glaucoma or ocular hypertension, helping to prevent optic‑nerve damage and preserve vision.

The combination works by two mechanisms: Latanoprost increases the outflow of aqueous humor through the uveoscleral pathway, while Timolol reduces aqueous humor production by blocking beta‑adrenergic receptors in the eye. Together they achieve a greater pressure‑lowering effect.

The prescribed dose is determined by the treating ophthalmologist. Typically, one drop is instilled in the affected eye(s) once daily, but the exact regimen should follow the prescriber’s instructions.

Safety data are limited. The product should be used during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant, and after consultation with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent drops, the Latanoprost/Timolol combination offers additive pressure‑lowering effects, often achieving target intraocular pressure with a single daily dose, which can improve adherence versus multiple separate medications.

Store the ophthalmic solution at temperatures below 25 °C, in the original container, protected from light and moisture. Do not freeze the product.

The solution is applied as eye drops. After washing hands, tilt the head back, pull down the lower eyelid to form a pocket, and place one drop into the conjunctival sac. Close the eye gently for a few seconds and avoid blinking excessively.

Serious risks include severe allergic reactions, marked bradycardia or bronchospasm in patients with respiratory disease, and persistent eye pain or vision loss. Patients should seek immediate medical attention if any of these occur.

Patients with known hypersensitivity to either component, severe asthma or chronic obstructive pulmonary disease, certain heart conduction disorders, or those who are pregnant or breastfeeding without medical advice should avoid using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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