Latanoprost Unimed Pharma (Latanoprost)

• Latanoprost is a prostaglandin analog used to manage conditions that involve elevated intra‑ocular pressure.
• Open‑angle glaucoma: lowers intra‑ocular pressure and helps preserve visual field.
• Ocular hypertension: reduces pressure to prevent progression to glaucoma.

• Latanoprost binds to prostaglandin F‑type receptors in the ciliary body, promoting remodeling of the extracellular matrix and increasing uveoscleral outflow of aqueous humor. This enhanced outflow lowers intra‑ocular pressure, addressing the primary pathophysiological factor in open‑angle glaucoma and ocular hypertension.

Latanoprost may cause ocular and peri‑ocular reactions, most of which are mild and reversible.

Common Side Effects

• Eye redness or hyperemia
• Increased eyelash length and thickness
• Darkening of the iris (especially in mixed‑color eyes)
• Eye irritation or foreign‑body sensation
• Blurred vision shortly after instillation
• Periocular skin hyperpigmentation

Serious or Rare Side Effects

• Severe allergic reaction (e.g., angio‑edema, anaphylaxis)
• Uveitis or iritis
• Corneal edema or keratitis
• Paradoxical increase in intra‑ocular pressure
• Endophthalmitis or intra‑ocular infection

• Before prescribing Latanoprost, clinicians should consider several safety aspects.
• Baseline intra‑ocular pressure assessment: verify pressure levels prior to initiation.
• Monitor iris color changes: document baseline iris pigmentation.
• History of ocular inflammation: avoid use in active uveitis.
• Concurrent ocular infection: do not use until infection resolved.
• Contact lens wearers: advise removal before instillation and waiting before reinsertion.
• Store at room temperature: keep in original container, protect from light and moisture.

Latanoprost can interact with other ocular or systemic agents, requiring attention to avoid reduced efficacy or increased adverse events.

Major Interactions (Avoid)

• Concomitant use with other prostaglandin analog eye drops may increase ocular irritation.
• Simultaneous topical corticosteroids can diminish Latanoprost's pressure‑lowering effect.
• Preservative‑containing contact lens solutions may exacerbate eye redness.

Moderate Interactions (Monitor Closely)

• Systemic carbonic anhydrase inhibitors may have additive pressure‑lowering effects.
• Topical ocular anesthetics can increase risk of corneal toxicity.
• Antihistamine eye drops may modestly affect tear film stability.