Product image of Latanoprost Zentiva (Latanoprost) supplied by GNH India

Latanoprost Zentiva

Active Ingredient:
Latanoprost
Origin:
EU

Latanoprost Zentiva (Latanoprost)

Latanoprost, the active ingredient in Latanoprost Zentiva, is a prostaglandin analog presented as eye drops for ocular use. It lowers intraocular pressure and is indicated for elevated intraocular pressure, open‑angle glaucoma, and ocular hypertension in adult patients.

GNH India supplies Latanoprost Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on reliable quality, regulatory compliance and timely delivery across multiple markets.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

Latanoprost is a prostaglandin analog that reduces intraocular pressure in several ocular conditions.

  • Elevated intraocular pressure: reduces pressure to prevent optic nerve damage.
  • Open-angle glaucoma: lowers pressure to slow disease progression and preserve visual field.
  • Ocular hypertension: decreases pressure to reduce risk of developing glaucoma.

How It Works

  • Latanoprost is a synthetic analogue of prostaglandin F2α that binds to FP receptors in the ciliary body. Activation of these receptors remodels the extracellular matrix of the uveoscleral pathway, enhancing aqueous humor outflow through the uveoscleral route. This mechanism provides a sustained pressure‑lowering effect after once‑daily administration and is independent of trabecular meshwork function.

Side Effects

Latanoprost may cause ocular and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Eye redness (hyperemia): mild conjunctival injection.
  • Increased eyelash growth: longer, thicker lashes.
  • Eye irritation or foreign‑body sensation.
  • Darkening of the iris: gradual increase in brown pigmentation.

Serious or Rare Side Effects

  • Severe intraocular inflammation (uveitis) requiring medical attention.
  • Allergic reaction with swelling, itching, or rash around the eye.
  • Corneal ulcer or keratitis that may threaten vision.

Precautions & Warnings

When prescribing Latanoprost, clinicians should consider several precautionary measures to ensure safe use.

  • Monitor intraocular pressure: assess response after initiation and adjust therapy as needed.
  • Avoid use with contact lenses: discontinue lenses at least 15 minutes before and after instillation.
  • Caution in patients with ocular infections: inflammation may be exacerbated.
  • Discontinue if severe allergic reaction occurs: seek immediate ophthalmologic evaluation.
  • Store at room temperature: keep bottle tightly closed, protect from light and freezing.

Avoid Interactions

Latanoprost can interact with other ophthalmic or systemic agents, influencing efficacy or safety.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory eye drops (e.g., ketorolac): may diminish pressure‑lowering effect.
  • Other prostaglandin analogues: combined use increases risk of pigmentary changes and inflammation.
  • Systemic prostaglandin therapy: potential additive ocular effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops (e.g., timolol): additive intraocular pressure reduction may cause hypotony.
  • Carbonic anhydrase inhibitor eye drops (e.g., dorzolamide): monitor for excessive pressure lowering.
  • Topical corticosteroids: may reduce Latanoprost efficacy; observe pressure trends.

Frequently Asked Questions

Latanoprost Zentiva is an ophthalmic solution indicated for lowering elevated intraocular pressure in conditions such as open‑angle glaucoma and ocular hypertension. By reducing pressure within the eye, it helps to protect the optic nerve and preserve visual function in adult patients.

Latanoprost is a synthetic prostaglandin F2α analogue that binds to FP receptors in the ciliary body. This binding remodels the extracellular matrix of the uveoscleral outflow pathway, increasing aqueous humor drainage through that route and consequently lowering intraocular pressure.

The prescribed regimen is determined by the treating ophthalmologist. Typically, one drop is instilled into the affected eye(s) once daily in the evening, but the exact dose and timing are individualized based on the patient’s response and clinical judgment.

Safety data for Latanoprost in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the prescriber.

To request Latanoprost Zentiva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Latanoprost belongs to the prostaglandin analogue class, which generally offers once‑daily dosing and a strong intraocular pressure‑lowering effect. Compared with beta‑blockers such as timolol, prostaglandin analogues often have a more sustained pressure reduction and a different side‑effect profile, making them a first‑line choice for many patients.

Latanoprost eye drops should be stored at room temperature, preferably below 25 °C. Keep the bottle tightly closed, protect it from direct light and avoid freezing. Once opened, use the product within the period specified by the manufacturer, typically 30 days, and discard any remaining solution after that time.

The solution is applied topically to the conjunctival sac. The patient should wash their hands, tilt the head back, pull down the lower eyelid to create a small pocket, and place a single drop into the eye. After instillation, close the eye gently and avoid blinking excessively for a few seconds.

Serious adverse events, although rare, include severe intraocular inflammation (uveitis), allergic reactions with swelling or rash around the eye, and corneal ulceration or keratitis that can threaten vision. Any sudden eye pain, vision loss, or marked redness should prompt immediate medical evaluation.

Latanoprost is contraindicated in patients with known hypersensitivity to the active ingredient or any component of the formulation. Caution is also advised for individuals with active ocular infections, severe inflammation, or a history of herpetic eye disease, as the medication may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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