Product image of Latira (Timolol Maleate, Latanoprost) supplied by GNH India

Latira

Active Ingredient:
Timolol Maleate, Latanoprost
Origin:
EU

Latira (Timolol Maleate, Latanoprost)

Timolol maleate and latanoprost, the active ingredients in Latira, are a beta‑blocker and prostaglandin analog combination presented as eye drops for ocular use. They lower intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension.

GNH India supplies Latira as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

  • Latira is used to manage conditions that involve elevated intra‑ocular pressure within the glaucoma disease family.
  • Open‑angle glaucoma: reduces intra‑ocular pressure to prevent optic nerve damage.
  • Ocular hypertension: lowers pressure to reduce risk of progression to glaucoma.
  • Post‑surgical ocular hypertension: helps control pressure after ocular surgery.

How It Works

  • Timolol maleate non‑selectively blocks beta‑adrenergic receptors in the ciliary body, decreasing aqueous humor production. Latanoprost, a prostaglandin F2α analogue, binds to FP receptors, enhancing uveoscleral outflow of aqueous humor. The combined actions result in a net reduction of intra‑ocular pressure, addressing the primary pathogenic factor in glaucoma and ocular hypertension.

Side Effects

Common Side Effects

  • Blurred vision: transient visual disturbance after instillation.
  • Eye irritation or burning: mild discomfort at the application site.
  • Conjunctival hyperemia: redness of the eye.
  • Increased eyelash growth: longer, thicker lashes.
  • Darkening of iris: gradual pigmentation change, especially in lighter eyes.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or difficulty breathing.
  • Persistent eye pain or inflammation: may indicate uveitis.
  • Sudden loss of vision: requires immediate medical attention.
  • Systemic bradycardia: slowed heart rate from systemic absorption.
  • Respiratory distress: bronchospasm in susceptible individuals.

Precautions & Warnings

  • Before initiating therapy, evaluate patient medical history and monitor intra‑ocular pressure regularly.
  • Assess cardiovascular status: avoid in patients with severe bradycardia or heart block.
  • Screen for respiratory disease: use cautiously in asthma or COPD.
  • Check for hypersensitivity: discontinue if allergic reaction occurs.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Latira may interact with other systemic or ocular agents that affect heart rate, blood pressure, or intra‑ocular pressure.

Major Interactions (Avoid)

  • Systemic beta‑blockers (e.g., propranolol): additive bradycardia.
  • Sympathomimetic eye drops (e.g., epinephrine): reduced efficacy of timolol.
  • Other prostaglandin analogs: increased risk of ocular hyperemia.

Moderate Interactions (Monitor Closely):\n- Carbonic anhydrase inhibitors (oral or topical): enhanced IOP‑lowering effect.

  • Anticholinergic eye drops: possible additive ocular irritation.
  • NSAID eye drops: may increase risk of corneal complications.

Frequently Asked Questions

Latira is a prescription eye‑drop formulation that combines timolol maleate and latanoprost to lower intra‑ocular pressure. It is indicated for patients with open‑angle glaucoma or ocular hypertension, helping to prevent optic nerve damage and preserve visual function.

Timolol maleate is a non‑selective beta‑adrenergic blocker. By inhibiting beta receptors in the ciliary body, it reduces the production of aqueous humor, which contributes to lowering intra‑ocular pressure in glaucoma patients.

The dosing regimen for Latira is determined by the prescribing ophthalmologist. Typically, one drop is instilled in the affected eye(s) once daily, but the exact dose and frequency are individualized based on the patient’s condition and response.

Safety data for Latira in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so clinicians must weigh potential benefits against possible risks before prescribing to pregnant or nursing women.

To request Latira, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Latira combines two mechanisms—beta‑blockade and prostaglandin‑mediated outflow enhancement—offering a greater intra‑ocular pressure reduction than either component alone. This dual action can simplify therapy by reducing the need for multiple separate eye‑drop bottles.

Latira should be stored at room temperature, below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain sterility.

Latira is administered as an ocular solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place one drop into the conjunctival sac of each prescribed eye. Avoid touching the tip of the bottle to the eye or any surface.

Serious risks include severe allergic reactions, sudden loss of vision, persistent eye pain or inflammation, systemic bradycardia, and bronchospasm in susceptible individuals. Any of these symptoms require immediate medical attention.

Latira is contraindicated in patients with known hypersensitivity to timolol, latanoprost, or any excipients, as well as those with severe bronchial asthma, chronic obstructive pulmonary disease, or significant cardiac conduction disorders such as second‑ or third‑degree heart block.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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