Product image of Latrigil (Lamotrigine) supplied by GNH India

Latrigil

Active Ingredient:
Lamotrigine
Origin:
EU

Latrigil (Lamotrigine)

Lamotrigine, the active ingredient in Latrigil, is an anticonvulsant presented as an oral tablet for oral use. It is employed to manage epilepsy and bipolar disorder, reducing seizure frequency and stabilizing mood in adult patients. The medication works by modulating neuronal excitability, offering a therapeutic option for patients with partial seizures, generalized tonic‑clonic seizures, and mood stabilization in bipolar type I.

GNH India supplies Latrigil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Lamotrigine is indicated for several seizure disorders and mood disorders, acting on the central nervous system to improve clinical outcomes.

  • Epilepsy (partial seizures): reduces seizure frequency and severity.
  • Generalized tonic‑clonic seizures: helps prevent seizure episodes.
  • Bipolar disorder (type I): stabilizes mood and decreases manic episodes.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, which stabilizes neuronal membranes and diminishes the release of excitatory neurotransmitters such as glutamate. By reducing neuronal hyperexcitability, it helps control abnormal electrical activity that underlies seizures and mood swings, providing therapeutic benefit in epilepsy and bipolar disorder.

Side Effects

Lamotrigine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Headache: mild to moderate cranial pain.
  • Nausea: feeling of stomach upset, sometimes with vomiting.
  • Rash: skin irritation that may be itchy or red.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction with blistering.
  • Toxic epidermal necrolysis: life‑threatening skin detachment.
  • Aseptic meningitis: inflammation of the meninges without infection.
  • Severe liver injury: marked elevation of hepatic enzymes or hepatic failure.

Precautions & Warnings

When prescribing Lamotrigine, clinicians should consider several safety measures.

  • Dose titration: increase gradually as directed by the prescriber to minimize rash risk.
  • Monitor blood counts: periodic CBC recommended, especially when combined with valproate.
  • Avoid abrupt discontinuation: sudden stop may precipitate seizures.
  • Pregnancy: assess risk versus benefit; limited data on fetal safety.
  • Drug interactions: review all concomitant medications for potential effects on lamotrigine levels.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lamotrigine interacts with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Valproic acid: markedly increases lamotrigine plasma concentrations.
  • Carbamazepine: significantly reduces lamotrigine levels, risking loss of efficacy.
  • Phenytoin: lowers lamotrigine concentrations, potentially leading to breakthrough seizures.
  • Phenobarbital: accelerates lamotrigine metabolism, decreasing its effect.
  • Oral contraceptives: may raise lamotrigine levels, necessitating dose adjustment.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): can modestly increase lamotrigine exposure.
  • Serotonergic agents (e.g., SSRIs): may raise the risk of serotonin syndrome.
  • Antifungal azoles (e.g., fluconazole): may slightly elevate lamotrigine concentrations.

Frequently Asked Questions

Latrigil contains lamotrigine, which is prescribed to control various types of seizures in epilepsy and to stabilize mood in adults with bipolar disorder type I. It helps reduce the frequency of partial and generalized tonic‑clonic seizures and prevents manic episodes.

Lamotrigine blocks voltage‑gated sodium channels on neurons, decreasing the release of excitatory neurotransmitters such as glutamate. This stabilises neuronal membranes, reduces abnormal electrical firing, and thereby lowers seizure activity and mood‑related neuronal dysregulation.

The dosage of Latrigil is individualized. A qualified prescriber determines the starting dose, titration schedule, and maintenance dose based on the patient’s condition, age, concomitant therapies, and response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lamotrigine in pregnancy and lactation are limited. It is classified as a drug where benefits must be weighed against potential risks to the fetus or infant. Healthcare providers should discuss individual circumstances and consider alternative therapies when appropriate.

To request Latrigil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with carbamazepine, another common anticonvulsant, lamotrigine generally has a lower risk of drug‑induced hyponatremia and fewer cognitive side effects, but it requires slower titration to avoid rash. Its efficacy in both focal and generalized seizures makes it a versatile option, though drug‑interaction profiles differ.

Latrigil tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiration date printed on the packaging.

Latrigil is taken orally, usually as a whole tablet swallowed with water. It is typically taken once or twice daily, depending on the prescriber’s titration plan. Patients should not crush, chew, or split the tablet unless specifically instructed.

The most serious adverse reactions include severe skin conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, aseptic meningitis, and significant liver injury. Prompt medical attention is required if a rash spreads, blisters develop, or symptoms of meningitis or hepatic dysfunction appear.

Latrigil is contraindicated in individuals with a known hypersensitivity to lamotrigine or any of its excipients. Caution is also advised for patients with a history of severe skin reactions, hepatic impairment, or those taking interacting medications that could markedly alter lamotrigine levels without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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