Product image of Lattulosio Almus (Lactulose) supplied by GNH India

Lattulosio Almus

Active Ingredient:
Lactulose
Origin:
EU

Lattulosio Almus (Lactulose)

Lactulose, the active ingredient in Lattulosio Almus, is an osmotic laxative presented as an oral preparation for oral use. It is indicated for the relief of constipation and for the management of hepatic encephalopathy in adult patients.

GNH India supplies Lattulosio Almus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution, ensuring product integrity from manufacturing to end‑user.

Manufacturer / TM Owner

Almus S.R.L.

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Indications & Clinical Uses

Lactulose is used as an osmotic laxative and ammonia‑lowering agent in specific gastrointestinal and hepatic conditions.

  • Constipation: Relieves chronic constipation by increasing stool water content and promoting bowel movements.
  • Hepatic encephalopathy: Reduces blood ammonia levels, helping to prevent or treat episodes of hepatic encephalopathy.
  • Pre‑procedure bowel cleansing: Facilitates colonic evacuation before diagnostic or therapeutic procedures.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolised by bacterial flora into short‑chain fatty acids, which increase the osmotic pressure within the lumen, drawing water into the bowel and softening stools. The acidic environment also converts ammonia to ammonium, reducing its absorption and lowering systemic ammonia levels.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects

  • Abdominal cramping
  • Flatulence
  • Diarrhea
  • Nausea

Serious or Rare Side Effects

  • Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Marked dehydration
  • Allergic reactions such as rash or angioedema
  • Hepatic decompensation in advanced liver disease

Precautions & Warnings

When prescribing lactulose, consider several safety measures to minimise risk.

  • Renal function assessment: Evaluate kidney function before initiating therapy, especially in patients with chronic kidney disease.
  • Electrolyte monitoring: Check serum electrolytes periodically during prolonged use.
  • Diabetes caution: Monitor blood glucose as lactulose may affect carbohydrate metabolism.
  • Intestinal obstruction: Avoid use in patients with known bowel obstruction or perforation.
  • Store at room temperature: Keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lactulose can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with other osmotic laxatives: May cause severe diarrhea and fluid loss.
  • Combination with potent diuretics: Increases risk of electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Mineral supplements (e.g., calcium, magnesium): May reduce lactulose efficacy by binding in the gut.
  • Antibiotics altering gut flora: May affect lactulose metabolism and ammonia reduction.
  • Probiotic products: Potentially modify intestinal fermentation, influencing therapeutic effect.

Frequently Asked Questions

Lattulosio Almus contains lactulose, which is employed to relieve chronic constipation and to lower blood ammonia levels in patients with hepatic encephalopathy. The drug works by drawing water into the colon, softening stools, and by converting ammonia to a non‑absorbable form.

Lactulose reaches the colon unchanged, where intestinal bacteria ferment it into short‑chain fatty acids. This fermentation creates an osmotic gradient that pulls water into the bowel, promoting laxation. The resulting acidic environment also traps ammonia as ammonium, decreasing its absorption and helping control hepatic encephalopathy.

The dose of lactulose is individualized by the prescribing clinician based on the patient’s condition, severity, and response. The prescriber determines the appropriate amount and frequency, and adjustments are made according to clinical effect and tolerability.

Safety data for lactulose in pregnancy and lactation are limited. It is generally categorized as a drug with unknown risk, and the decision to use it should be made by a healthcare professional after weighing potential benefits against possible risks to the mother and infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose is an osmotic laxative, differing from stimulant laxatives that act on intestinal nerves. It provides a gentler, water‑based softening effect and also lowers ammonia levels, a benefit not shared by most other laxatives. Its dual action makes it especially useful in patients with liver disease.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from moisture and direct sunlight to maintain stability. No special refrigeration is required for this oral formulation.

Lattulosio Almus is taken orally, usually as a liquid or solution, according to the prescriber’s instructions. It can be measured with a calibrated device and may be mixed with a small amount of water or juice to improve palatability.

Serious concerns include severe electrolyte disturbances, marked dehydration, and rare allergic reactions such as rash or angioedema. In patients with advanced liver disease, monitoring for hepatic decompensation is advisable.

Lactulose should be avoided in individuals with known or suspected intestinal obstruction, perforation, or severe inflammatory bowel disease. Patients with hypersensitivity to lactulose or its excipients should also refrain from using the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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