Product image of Lattulosio Aurobindo (Lactulose) supplied by GNH India

Lattulosio Aurobindo

Active Ingredient:
Lactulose
Origin:
EU

Lattulosio Aurobindo (Lactulose)

Lactulose, the active ingredient in Lattulosio Aurobindo, is an osmotic laxative presented as an oral dosage form for oral use. It is employed to relieve constipation and to reduce ammonia absorption in patients with hepatic encephalopathy, particularly in adults and children where appropriate.

GNH India supplies Lattulosio Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on reliable quality and regulatory compliance. The product conforms to European Union pharmacopeial standards and is available for export to multiple regions.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Lactulose is used as an osmotic laxative and ammonia‑lowering agent in the following clinical situations:

  • Constipation: Softens stool and promotes bowel movements by increasing water content in the intestinal lumen.
  • Hepatic encephalopathy: Lowers colonic ammonia production, helping to improve mental status in patients with liver disease.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon, bacterial enzymes hydrolyze it to short‑chain fatty acids, which increase the osmotic pressure and draw water into the lumen, softening feces. The resulting acidic environment converts ammonia (NH₃) to ammonium (NH₄⁺), reducing its absorption and systemic levels, thereby mitigating hepatic encephalopathy. Overall, the effect facilitates bowel clearance and ammonia detoxification.

Side Effects

Lactulose may cause a range of adverse reactions, most of which are related to its laxative action.

Common Side Effects

  • Diarrhea: Loose stools, especially at higher doses.
  • Abdominal cramping: Stomach cramps or discomfort.
  • Flatulence: Increased intestinal gas.
  • Nausea: Feeling of sickness.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: Low potassium or sodium levels.
  • Allergic reaction: Rash, itching, or swelling.

Precautions & Warnings

When prescribing lactulose, consider the following precautions to ensure safe and effective use.

  • Assess renal function: Adjust use in patients with severe kidney impairment.
  • Monitor fluid balance: Watch for dehydration, especially in the elderly.
  • Evaluate electrolyte status: Check potassium and sodium levels during therapy.
  • Use caution in bowel obstruction: Avoid in complete mechanical obstruction.
  • Pregnancy and lactation: Safety not established; weigh benefits against potential risks.
  • Store at ambient temperature: Keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Lactulose can interact with other medicines; awareness of key interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: May reduce lactulose efficacy by altering colonic pH.
  • Oral antibiotics: Disruption of gut flora can diminish lactulose’s conversion to acids.

Moderate Interactions (Monitor Closely)

  • Diuretics: Increased risk of electrolyte disturbances.
  • Insulin or oral hypoglycemics: Altered glucose absorption may affect blood sugar control.
  • Other laxatives: Potential for excessive diarrhea and dehydration.

Frequently Asked Questions

Lattulosio Aurobindo contains lactulose, which is prescribed to relieve constipation and to lower blood ammonia levels in patients with hepatic encephalopathy. The drug works by increasing water content in the colon, softening stool, and creating an acidic environment that reduces ammonia absorption.

Lactulose is a synthetic sugar that reaches the colon unchanged, where intestinal bacteria break it down into short‑chain fatty acids. These acids raise the osmotic pressure, drawing water into the bowel to soften stool, and they acidify the colonic contents, converting ammonia to non‑absorbable ammonium, thereby decreasing systemic ammonia.

The dose of lactulose is individualized by the prescribing clinician based on the patient’s condition, age, and response. Typical regimens differ for constipation versus hepatic encephalopathy, and adjustments are made according to therapeutic effect and tolerability.

Safety data for lactulose in pregnancy and lactation are limited. It is classified as a category where benefits must be weighed against potential risks. Healthcare providers should evaluate each case and consider alternative treatments if appropriate.

To request Lattulosio Aurobindo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose differs from agents such as polyethylene glycol in that it is metabolized by colonic bacteria to produce acids, providing both laxative and ammonia‑lowering effects. Polyethylene glycol acts solely as an osmotic agent without influencing colonic pH, making lactulose the preferred choice when hepatic encephalopathy is also a concern.

Lattulosio Aurobindo should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lattulosio Aurobindo is taken orally, usually as a liquid solution. The dose is measured with a calibrated device or spoon as directed by the prescriber, and it can be taken with or without food. Adequate fluid intake is recommended to support its laxative effect.

Serious risks include severe electrolyte disturbances such as hypokalemia, dehydration from excessive diarrhea, and rare allergic reactions presenting as rash, itching or swelling. Patients should seek medical attention if they experience persistent watery stools, muscle weakness, or signs of an allergic response.

Lactulose is contraindicated in individuals with a known hypersensitivity to the drug, in patients with complete mechanical bowel obstruction, and in those with severe renal impairment unless closely monitored. It should also be used with caution in patients prone to electrolyte imbalances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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