Product image of Lattulosio Eg (Lactulose) supplied by GNH India

Lattulosio Eg

Active Ingredient:
Lactulose
Origin:
EU

Lattulosio Eg (Lactulose)

Lactulose, the active ingredient in Lattulosio Eg, is an osmotic laxative presented as an oral formulation for oral use. It is used to relieve constipation and to reduce blood ammonia levels in patients with hepatic encephalopathy, particularly in adult populations.

GNH India supplies Lattulosio Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Eg S.P.A.

1
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Indications & Clinical Uses

Lactulose is employed in the management of gastrointestinal and hepatic conditions where reduction of intestinal ammonia or promotion of bowel movements is required.

  • Constipation: Facilitates bowel movements by increasing water content in the colon, relieving occasional or chronic constipation.
  • Hepatic encephalopathy: Lowers intestinal ammonia absorption, helping to prevent or treat episodes of hepatic encephalopathy in patients with liver disease.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolised by bacterial flora into short‑chain fatty acids, which increase the osmotic pressure within the lumen, drawing water into the bowel and acidifying the contents. The resulting environment promotes peristalsis and traps ammonia as ammonium ions, reducing systemic absorption.

Side Effects

Lactulose may cause a range of gastrointestinal and systemic reactions, most of which are mild and transient.

Common Side Effects

  • Bloating: sensation of abdominal fullness.
  • Flatulence: increased intestinal gas.
  • Abdominal cramps: mild to moderate discomfort.
  • Diarrhea: loose stools, especially at higher doses.
  • Nausea: feeling of sickness.
  • Thirst: increased desire for fluids.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: especially hyponatremia or hypokalemia.
  • Dehydration: due to excessive fluid loss.
  • Allergic reaction: rash, itching, or swelling.
  • Severe abdominal pain: persistent or worsening pain.
  • Acute hepatic decompensation: rare worsening of liver function.

Precautions & Warnings

Before initiating lactulose therapy, consider the following safety measures.

  • Assess renal function: use with caution in severe renal impairment.
  • Monitor electrolytes: watch for hyponatremia or potassium loss.
  • Avoid abrupt discontinuation: may lead to rebound constipation.
  • Use cautiously in diabetic patients: monitor blood glucose as lactulose can affect carbohydrate metabolism.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lactulose can interact with other medications that affect electrolyte balance or gastrointestinal function.

Major Interactions (Avoid)

  • Antibiotics (e.g., neomycin): may reduce lactulose efficacy by altering gut flora.
  • Magnesium‑containing laxatives: additive osmotic effect can cause severe dehydration.
  • Loop or thiazide diuretics: increased risk of electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Antacids: may change colonic pH and affect lactulose activity.
  • Metformin: potential for additive gastrointestinal side effects.
  • Probiotics: generally safe but may modify gut flora dynamics.

Frequently Asked Questions

Lattulosio Eg contains lactulose, which is used primarily to treat constipation and to lower blood ammonia levels in patients with hepatic encephalopathy. By increasing water content in the colon, it promotes regular bowel movements, and by acidifying the intestinal environment, it helps trap ammonia, reducing its absorption into the bloodstream.

Lactulose is a synthetic sugar that reaches the colon unchanged, where intestinal bacteria ferment it into short‑chain fatty acids. This process raises the osmotic pressure in the lumen, drawing water into the bowel and softening stool. The acidic environment also converts ammonia to ammonium, which is less readily absorbed, thereby lowering systemic ammonia levels.

The appropriate dose of lactulose is individualized by a healthcare professional based on the patient’s condition, age, renal function, and response to therapy. Prescribers typically start with a low dose and adjust gradually to achieve the desired clinical effect while minimizing side effects.

Safety data for lactulose during pregnancy and lactation are limited. It is generally considered low risk because it is minimally absorbed, but the decision to use it should be made by a qualified clinician after weighing potential benefits against any uncertain risks.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lattulosio Eg. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lactulose is an osmotic laxative, differing from stimulant laxatives such as bisacodyl, which act by directly stimulating intestinal motility. Osmotic agents like lactulose draw water into the colon, offering a gentler, often better‑tolerated option for chronic constipation and providing the added benefit of ammonia reduction in liver disease.

Store Lattulosio Eg at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lattulosio Eg is taken orally, usually as a liquid solution. It can be measured with a calibrated dosing device and swallowed directly or mixed with a small amount of water or juice to improve palatability, following the prescribing clinician’s instructions.

Serious risks include severe electrolyte disturbances such as hyponatremia or hypokalemia, marked dehydration from excessive diarrhea, and rare allergic reactions. Patients should be monitored for signs of these conditions, especially when high doses are used or when concomitant medications affect fluid and electrolyte balance.

Lactulose should be avoided in individuals with known hypersensitivity to the drug, those with intestinal obstruction, perforation, or severe inflammatory bowel disease, and patients with uncontrolled diabetes without appropriate monitoring, as it may affect carbohydrate metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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