Product image of Latuda (Lurasidone) supplied by GNH India

Latuda

Active Ingredient:
Lurasidone
Origin:
EU

Latuda (Lurasidone)

Lurasidone, the active ingredient in Latuda, is an atypical antipsychotic presented as an oral tablet for oral use. It is indicated for the treatment of schizophrenia and for depressive episodes associated with bipolar I disorder in adult patients.

GNH India supplies Latuda as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU regulatory standards and is manufactured under strict quality‑assured processes.

Manufacturer / TM Owner

Angelini Pharma S.P.A.

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Indications & Clinical Uses

Lurasidone (Latuda) is employed in the management of serious psychiatric conditions within the psychotic and mood disorder spectrum.

  • Schizophrenia: reduces psychotic symptoms and helps prevent relapse in adult patients.
  • Bipolar I disorder (depressive episodes): alleviates depressive symptoms and improves overall mood stability.
  • Maintenance treatment of schizophrenia: supports long‑term symptom control.

How It Works

  • Lurasidone acts primarily as an antagonist at dopamine D2 and serotonin 5‑HT2A receptors, while partially agonizing 5‑HT1A receptors and antagonizing 5‑HT7 receptors. This combined receptor profile modulates dopaminergic and serotonergic neurotransmission, contributing to antipsychotic and mood‑stabilising effects in the central nervous system.

Side Effects

Common Side Effects

  • Nausea
  • Akathisia (restlessness)
  • Somnolence or insomnia
  • Headache
  • Weight gain
  • Dizziness

Serious or Rare Side Effects

  • Tardive dyskinesia
  • Neuroleptic malignant syndrome
  • Agranulocytosis or severe neutropenia
  • Seizures
  • Suicidal thoughts or behaviours
  • Metabolic disturbances such as hyperglycaemia

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor patients regularly.

  • Metabolic monitoring: check weight, glucose and lipid levels periodically.
  • Suicidality assessment: evaluate for depressive symptoms and suicidal ideation, especially early in treatment.
  • Cardiac evaluation: consider ECG monitoring in patients with known QT prolongation.
  • Hepatic function: use caution and adjust dose in moderate to severe hepatic impairment.
  • Discontinuation: avoid abrupt cessation; taper under medical supervision.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Lurasidone may interact with several concomitant medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lurasidone exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect.
  • Monoamine oxidase inhibitors (MAOIs): risk of additive CNS effects.

Moderate Interactions (Monitor Closely):\n- Other antipsychotics or dopamine‑modulating agents: increased risk of extrapyramidal symptoms.

  • CNS depressants (e.g., benzodiazepines, alcohol): enhanced sedation.
  • QT‑prolonging drugs (e.g., certain antiarrhythmics, fluoroquinolones): monitor cardiac rhythm.

Frequently Asked Questions

Latuda (lurasidone) is prescribed for adult patients with schizophrenia and for the depressive episodes of bipolar I disorder. In both indications it helps reduce psychotic symptoms, improve mood stability and prevent relapse when used as part of a comprehensive treatment plan.

Lurasidone blocks dopamine D2 and serotonin 5‑HT2A receptors while partially stimulating 5‑HT1A receptors and blocking 5‑HT7 receptors. This mixed activity balances dopaminergic and serotonergic pathways, which underlies its antipsychotic and mood‑stabilising properties.

The appropriate dose of Latuda is individualized by the prescribing clinician based on the patient’s diagnosis, response, and tolerability. Starting doses, titration steps and maximum limits are defined in the product label, and the prescriber determines the exact regimen for each patient.

Safety data for lurasidone in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risks with their healthcare provider.

To request Latuda, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with many atypical antipsychotics, lurasidone has a relatively low risk of metabolic side effects such as weight gain and dyslipidaemia, while still providing robust efficacy for schizophrenia and bipolar depression. Its receptor profile also offers a modest antidepressant effect, distinguishing it from agents that focus primarily on psychosis.

Latuda tablets should be stored at room temperature, below 25 °C (77 °F). Keep them in the original blister pack, protect from moisture and direct sunlight, and store out of reach of children.

Latuda is taken orally as a whole tablet, usually once daily with food to enhance absorption. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their clinician, without crushing or chewing the tablet.

Serious risks include the potential for tardive dyskinesia, neuroleptic malignant syndrome, severe neutropenia or agranulocytosis, seizures, and emergent suicidal thoughts or behaviours, particularly early in treatment. Prompt medical attention is required if any of these events occur.

Latuda is contraindicated in patients with known hypersensitivity to lurasidone or any of its excipients. Caution is advised for individuals with severe hepatic impairment, a history of prolonged QT interval, or those currently taking strong CYP3A4 inhibitors or inducers without appropriate dose adjustments.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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