Product image of Lavestra H (Losartan Potassium, Hydrochlorothiazide) supplied by GNH India

Lavestra H

Active Ingredient:
Losartan Potassium, Hydrochlorothiazide
Origin:
EU

Lavestra H (Losartan Potassium, Hydrochlorothiazide)

Losartan potassium and hydrochlorothiazide, the active ingredient in Lavestra H, is an angiotensin II receptor blocker and thiazide diuretic presented as an oral tablet for systemic use. It is indicated for the management of hypertension and for reducing fluid overload in adults.
GNH India supplies Lavestra H as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Lavestra H combines an angiotensin II receptor blocker with a thiazide diuretic to lower elevated blood pressure and reduce excess fluid.

  • Hypertension: lowers systolic and diastolic pressure in patients with primary hypertension.
  • Edema: promotes diuresis to relieve fluid accumulation associated with congestive states.
  • Cardiovascular risk reduction: contributes to long‑term risk management when used as part of a comprehensive antihypertensive regimen.

How It Works

  • Losartan potassium selectively blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction, aldosterone release, and sodium retention. Hydrochlorothiazide inhibits NaCl reabsorption in the distal convoluted tubule, increasing natriuresis and diuresis, which together lower plasma volume and systemic vascular resistance, resulting in reduced blood pressure.

Side Effects

Lavestra H may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Increased urination or nocturia
  • Electrolyte disturbances such as low potassium
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance
  • Hyperkalemia or significant potassium loss
  • Acute kidney injury or worsening renal function
  • Angioedema or severe allergic reaction
  • Marked hypotension leading to syncope

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor relevant parameters.

  • Blood pressure monitoring: ensure adequate control without excessive hypotension.
  • Electrolyte assessment: check potassium and sodium levels regularly.
  • Renal function: evaluate serum creatinine and eGFR, especially in patients with pre‑existing kidney disease.
  • Pregnancy: avoid use in pregnancy due to fetal risk (Category D).
  • Concomitant NSAIDs: use with caution as they may impair renal function.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lavestra H can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: increased risk of renal impairment and hyperkalemia.
  • Potassium supplements or high‑potassium diets: may precipitate hyperkalemia.
  • ACE inhibitors or other ARBs: additive effects on potassium and renal function.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce antihypertensive efficacy and affect renal clearance.
  • Lithium: increased lithium levels, risk of toxicity.
  • CYP2C9 inhibitors (e.g., fluconazole): may raise losartan plasma concentrations.

Frequently Asked Questions

Lavestra H is prescribed to lower high blood pressure (hypertension) and to reduce fluid retention (edema) in adults. The combination of losartan and hydrochlorothiazide provides both vasodilatory and diuretic effects, helping to control cardiovascular risk and manage excess fluid associated with various medical conditions.

Losartan potassium blocks the angiotensin II type 1 (AT1) receptors, preventing the hormone from causing blood vessels to narrow, reducing aldosterone release, and limiting sodium and water retention. This leads to vasodilation, decreased blood volume, and ultimately lower blood pressure.

The specific dose of Lavestra H is determined by the prescribing clinician based on the patient’s blood pressure, renal function, electrolyte status, and overall health. Dosage adjustments are individualized, and patients should follow the exact regimen provided by their healthcare professional.

Lavestra H is classified as Pregnancy Category D, indicating evidence of fetal risk and it should be avoided during pregnancy. It is also not recommended while breastfeeding because the drug may pass into breast milk and affect the infant. Alternative therapies should be discussed with a healthcare provider.

To request Lavestra H, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lavestra H combines an angiotensin II receptor blocker (losartan) with a thiazide diuretic (hydrochlorothiazide), offering dual mechanisms that many single‑agent therapies lack. Compared with monotherapy, the combination can achieve better blood‑pressure control with a single pill, but clinicians must consider individual tolerance, electrolyte balance, and renal function.

Lavestra H tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Lavestra H is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the tablet whole with a full glass of water and do not crush or chew it unless specifically instructed.

Serious risks include severe dehydration, electrolyte disturbances (especially low potassium), acute kidney injury, hyperkalemia, angioedema, and marked hypotension that can lead to fainting. Patients should seek immediate medical attention if they experience swelling of the face or throat, rapid weight loss, or persistent dizziness.

Lavestra H should be avoided in patients with known hypersensitivity to losartan, hydrochlorothiazide, or any component of the formulation. It is contraindicated in pregnancy, in individuals with severe renal impairment, and in those with anuria. Caution is also advised for patients with severe liver disease or electrolyte abnormalities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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