Product image of Lavestra Hct (Losartan Potassium, Hydrochlorothiazide) supplied by GNH India

Lavestra Hct

Active Ingredient:
Losartan Potassium, Hydrochlorothiazide
Origin:
EU

Lavestra Hct (Losartan Potassium, Hydrochlorothiazide)

Losartan potassium and hydrochlorothiazide, the active ingredients in Lavestra Hct, are an angiotensin II receptor blocker and a thiazide diuretic presented as an oral tablet for systemic use. They treat hypertension in adult patients.

GNH India supplies Lavestra Hct as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Lavestra Hct combines an angiotensin II receptor blocker with a thiazide diuretic and is indicated for conditions related to elevated blood pressure.

  • Hypertension: lowers systolic and diastolic blood pressure in adults with primary hypertension.
  • Essential hypertension: helps achieve target blood pressure when monotherapy is insufficient.
  • High blood pressure: provides additive blood‑pressure control through dual mechanisms.

How It Works

  • Losartan potassium selectively blocks AT1 angiotensin II receptors, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and reducing plasma volume. The combined actions result in decreased peripheral resistance and lowered blood pressure.

Side Effects

Lavestra Hct may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia
  • Angioedema
  • Liver enzyme elevation
  • Blood dyscrasias (e.g., agranulocytosis)

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor appropriately.

  • Renal impairment: assess kidney function and adjust therapy as needed.
  • Electrolyte balance: monitor serum potassium and sodium levels regularly.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Pregnancy: avoid use unless clearly indicated by a physician.
  • Elderly patients: start at lower doses and monitor for orthostatic hypotension.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Lavestra Hct can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • ACE inhibitors or ARBs combined with aliskiren in diabetes: increased renal risk.
  • NSAIDs: may reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: thiazide component can raise lithium levels.
  • Antidiabetic agents: may require dose adjustment due to blood‑pressure changes.
  • CYP2C9 inhibitors (e.g., fluconazole): can increase losartan exposure.

Frequently Asked Questions

Lavestra Hct is an oral antihypertensive medication that combines losartan potassium, an angiotensin II receptor blocker, with hydrochlorothiazide, a thiazide diuretic. The combination is prescribed to lower elevated blood pressure in adult patients, helping to reduce the risk of cardiovascular complications associated with hypertension.

Losartan potassium blocks AT1 receptors for angiotensin II, preventing the hormone from causing blood‑vessel constriction and aldosterone release. This leads to vasodilation and reduced sodium‑water retention, contributing to lower systemic blood pressure when used together with the diuretic component.

The specific dose of Lavestra Hct is determined by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and other clinical factors. Healthcare professionals adjust the regimen to achieve optimal blood‑pressure control while minimizing adverse effects.

Safety of Lavestra Hct in pregnancy or lactation has not been established. It should be avoided unless the potential benefit justifies the risk, and only under direct medical supervision. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with monotherapy agents, Lavestra Hct offers dual‑action blood‑pressure control through both receptor blockade and diuresis, often achieving target pressures with a single pill. This can improve adherence versus taking separate losartan and thiazide tablets, though individual response and tolerability vary.

Lavestra Hct tablets should be stored at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain product stability.

Lavestra Hct is taken orally, usually once daily, with or without food as directed by a healthcare professional. Swallow the tablet whole with a full glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious risks include severe hypotension, acute kidney injury, hyperkalemia, and angioedema. Patients should be monitored for sudden drops in blood pressure, changes in renal function, electrolyte imbalances, and any signs of swelling of the face, lips, or throat, which require immediate medical attention.

Lavestra Hct is contraindicated in patients with known hypersensitivity to losartan, hydrochlorothiazide, or any component of the formulation. It should also be avoided in individuals with severe renal impairment, anuria, or those taking potassium‑sparing agents that could precipitate dangerous electrolyte disturbances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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