Product image of Laxido Nature (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Laxido Nature

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Laxido Nature (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Laxido Nature, is an osmotic laxative presented as an oral powder for oral use. Combined with sodium hydrogen carbonate, potassium chloride and sodium chloride, it helps soften stool and promote regular bowel movements in adults and children with occasional constipation.

GNH India supplies Laxido Nature as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with reliable logistics and support for procurement teams.

Manufacturer / TM Owner

Intergal Pharma Ireland Limited

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Indications & Clinical Uses

Laxido Nature, an osmotic laxative, is used to manage conditions related to impaired bowel motility and hard stool formation.

  • Constipation: Relieves functional constipation by softening stool and facilitating bowel movements.
  • Opioid‑induced constipation: Improves bowel regularity in patients receiving opioid therapy.
  • Bowel preparation: Clears the intestinal tract before colonoscopy or imaging studies.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is poorly absorbed from the gastrointestinal tract. It retains water in the intestinal lumen by creating an osmotic gradient, increasing stool water content and volume. The added electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain electrolyte balance while enhancing the osmotic effect, resulting in softened stool and stimulated peristalsis thereby promoting regular bowel movements.

Side Effects

Laxido Nature may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating: Mild distension of the abdomen.
  • Flatulence: Increased intestinal gas.
  • Nausea: Feeling of sickness.
  • Diarrhea: Loose, watery stools.
  • Abdominal cramps: Intermittent stomach pain.
  • Electrolyte imbalance: Minor changes in serum sodium or potassium.

Serious or Rare Side Effects

  • Severe dehydration: Marked loss of body fluids.
  • Persistent diarrhea: Ongoing watery stools leading to electrolyte loss.
  • Allergic reaction: Rash, itching, swelling, or difficulty breathing.
  • Rectal bleeding: Unexplained blood in stool.
  • Severe abdominal pain: Intense, continuous pain.

Precautions & Warnings

Before using Laxido Nature, consider the following precautions to ensure safe and effective therapy.

  • Assess renal function: Use with caution in patients with impaired kidney function.
  • Monitor electrolyte status: Check serum sodium and potassium levels during prolonged use.
  • Evaluate gastrointestinal obstruction: Avoid in cases of suspected bowel blockage.
  • Use in pregnancy only if necessary: Discuss risks with a healthcare professional.
  • Adjust dose in the elderly: Start with the lowest effective amount.
  • Store at ambient temperature: Keep below 25°C in the original container, protected from moisture.

Avoid Interactions

Laxido Nature can interact with other medicines, affecting their absorption or electrolyte balance.

Major Interactions (Avoid)

  • Digoxin: Electrolyte shifts may increase risk of toxicity.
  • Lithium: Increased lithium levels due to altered renal clearance.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: May reduce laxative efficacy.
  • Oral antibiotics: May affect gut flora and bowel habits.
  • Diuretics: Potential for additive electrolyte disturbances.
  • Calcium channel blockers: Possible enhancement of hypotensive effects.

Frequently Asked Questions

Laxido Nature is an oral osmotic laxative indicated for the relief of occasional constipation and for bowel cleansing before diagnostic procedures such as colonoscopy. It works by increasing water content in the stool, making evacuation easier.

Macrogol 3350, a high‑molecular‑weight polyethylene glycol, is poorly absorbed and draws water into the intestinal lumen through osmotic activity. The added electrolytes help maintain fluid balance while the increased stool water softens the stool and stimulates peristalsis.

The dose of Laxido Nature is individualized by a prescriber based on the patient’s age, severity of constipation, and clinical response. Healthcare professionals determine the appropriate amount and duration of therapy.

Safety data for Laxido Nature in pregnancy or lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with stimulant laxatives, Laxido Nature (PEG‑based) works by osmotic water retention rather than stimulating intestinal muscles, resulting in a gentler, more predictable stool softening. It is often preferred for long‑term or repeated use because it has a lower risk of dependence.

Laxido Nature should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Laxido Nature is supplied as an oral powder that is dissolved in water or another clear fluid as directed by the prescriber. The solution is then consumed orally, typically once daily, with the exact volume and timing defined by the treating clinician.

Serious risks include severe dehydration, electrolyte disturbances, and rare allergic reactions such as rash or breathing difficulty. Persistent diarrhea can also lead to significant fluid loss. Patients should seek medical attention if they experience these symptoms.

Laxido Nature should be avoided in individuals with known hypersensitivity to any component, in patients with intestinal obstruction, perforation, or severe inflammatory bowel disease, and in those for whom electrolyte balance cannot be safely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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