Product image of Laxido Nature (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Laxido Nature

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Laxido Nature (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Laxido Nature, is an osmotic laxative presented as an oral formulation for oral use. It treats constipation in adults and children when other measures are insufficient.

GNH India supplies Laxido Nature as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Intergal Pharma Ireland Limited

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Indications & Clinical Uses

Laxido Nature, containing macrogol 3350, is used to manage constipation by increasing intestinal water content.

  • Functional constipation: softens stool and facilitates regular bowel movements.
  • Chronic idiopathic constipation: provides long‑term relief of persistent constipation.
  • Opioid‑induced constipation: counteracts opioid‑related reduction in gut motility.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polymer that remains largely unabsorbed in the gastrointestinal tract. Its osmotic activity draws water into the intestinal lumen, increasing stool water content, softening the fecal mass and promoting peristalsis, which together facilitate easier passage of stool.

Side Effects

Laxido Nature may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Nausea
  • Abdominal cramps
  • Diarrhoea
  • Increased thirst

Serious or Rare Side Effects

  • Electrolyte imbalance (e.g., hyponatraemia)
  • Severe dehydration
  • Allergic reactions such as rash or angioedema
  • Severe abdominal pain
  • Rectal bleeding

Precautions & Warnings

Before initiating therapy with Laxido Nature, consider the following safety measures.

  • Renal function assessment: ensure adequate kidney function before use.
  • Electrolyte monitoring: check serum electrolytes in patients at risk.
  • Bowel obstruction: avoid in known or suspected mechanical obstruction.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Elderly patients: start with the lowest effective dose.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Macrogol 3350 can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent osmotic laxatives: risk of excessive fluid loss and electrolyte disturbances.
  • Loop diuretics: may exacerbate potassium depletion.
  • Lithium: altered lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • Magnesium‑containing antacids: additive laxative effect.
  • NSAIDs: potential for renal impairment when combined.
  • ACE inhibitors: monitor potassium levels.

Frequently Asked Questions

Laxido Nature is an oral osmotic laxative that contains macrogol 3350. It is used to relieve occasional or chronic constipation by increasing the water content of stool, making it softer and easier to pass.

Macrogol 3350 is a large polymer that stays within the gastrointestinal tract. Its osmotic activity draws water from the surrounding tissues into the intestinal lumen, which softens the stool and stimulates peristalsis, thereby promoting regular bowel movements.

The dose of Laxido Nature is individualized by the prescribing healthcare professional based on the patient’s age, severity of constipation, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for macrogol 3350 in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Laxido Nature, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, macrogol 3350 works by osmotic water retention rather than stimulating intestinal muscles, which often results in a gentler, more predictable effect and fewer cramping side effects. It is also preferred over bulk‑forming agents for patients needing rapid stool softening.

Laxido Nature should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Laxido Nature is taken orally. The powder is typically dissolved in a specified amount of water or another suitable liquid, mixed thoroughly, and consumed as directed by the prescriber. It should be taken with a full glass of water to aid absorption.

Serious risks include severe electrolyte disturbances, dehydration, and rare allergic reactions such as rash or angioedema. Patients experiencing symptoms like faintness, rapid heartbeat, severe abdominal pain, or swelling should seek medical attention promptly.

Laxido Nature should not be used by individuals with known hypersensitivity to macrogol 3350 or any of its excipients, and it is contraindicated in patients with intestinal obstruction, perforation, or severe inflammatory bowel disease unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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