Product image of Laxido Orange (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Laxido Orange

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Laxido Orange (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Laxido Orange, is an osmotic laxative presented as a powder for oral solution for oral use. It is indicated for the relief of occasional constipation in adults and children when dietary measures are insufficient.

GNH India supplies Laxido Orange as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant packaging for global distribution, offering reliable lead times and comprehensive technical support throughout the supply chain.

Manufacturer / TM Owner

Intergal Pharma Ireland Limited

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Indications & Clinical Uses

Laxido Orange (macrogol 3350) is an osmotic laxative used to manage constipation.

  • Occasional constipation: softens stool and facilitates regular bowel movements.
  • Functional constipation: improves stool frequency and consistency in chronic cases.
  • Opioid‑induced constipation: alleviates reduced bowel motility associated with opioid therapy.

How It Works

  • Macrogol 3350 exerts its laxative effect by remaining largely unabsorbed in the gastrointestinal tract, where it creates an osmotic gradient that draws water into the intestinal lumen. The increased fluid content softens fecal mass, expands luminal volume, and stimulates peristalsis, thereby promoting the passage of stool without stimulating intestinal secretions. The polymer’s high molecular weight prevents systemic absorption, ensuring the action remains confined to the gut and minimizing systemic side effects.

Side Effects

Macrogol 3350 may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Nausea
  • Diarrhea
  • Abdominal cramps
  • Headache

Serious or Rare Side Effects

  • Severe dehydration
  • Electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Allergic reactions such as rash or angioedema
  • Severe abdominal pain
  • Rectal bleeding
  • Anaphylaxis (rare)

Precautions & Warnings

Before using Laxido Orange, consider the following precautions to ensure safe and effective therapy.

  • Assess renal function: avoid or adjust use in patients with severe renal impairment.
  • Monitor electrolytes: the formulation contains sodium, potassium and chloride, requiring periodic electrolyte assessment.
  • Avoid in intestinal obstruction: contraindicated in mechanical blockage of the bowel.
  • Use with caution in the elderly: increased susceptibility to dehydration and electrolyte shifts.
  • Pregnancy and lactation: consult a healthcare professional before use, as safety data are limited.
  • Store at ambient temperature: keep the powder in its original container, protect from moisture and heat.

Avoid Interactions

Macrogol 3350 can interact with other medicines, affecting electrolyte balance or renal function.

Major Interactions (Avoid)

  • Concurrent use with other osmotic laxatives: risk of severe electrolyte disturbance.
  • Combination with loop diuretics: may exacerbate loss of sodium and potassium.
  • Co‑administration with high‑dose NSAIDs: increased potential for renal impairment.

Moderate Interactions (Monitor Closely)

  • Use with antacids containing sodium or potassium: additive electrolyte load may require monitoring.
  • Concomitant digoxin therapy: monitor serum potassium levels to avoid toxicity.
  • Concurrent corticosteroid therapy: observe fluid and electrolyte status closely.

Frequently Asked Questions

Laxido Orange contains macrogol 3350, an osmotic laxative indicated for the relief of occasional and chronic constipation in adults and children when dietary measures are insufficient. It works by increasing water content in the intestinal lumen to soften stool and promote bowel movements.

Macrogol 3350 is a high‑molecular‑weight polymer that is not absorbed systemically. It stays in the gastrointestinal tract, creating an osmotic gradient that draws water into the lumen. The added fluid softens feces, expands intestinal volume and stimulates peristalsis, facilitating stool passage.

The appropriate dose of Laxido Orange is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of constipation and response to therapy. Patients should follow the individual dosing instructions provided on the prescription label and not exceed the recommended amount.

Safety data for macrogol 3350 in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits and risks before prescribing Laxido Orange to pregnant or nursing women. Use is generally considered only when non‑pharmacologic measures have failed and the expected benefit outweighs possible risks.

To place an order, submit an enquiry on the Laxido Orange product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, macrogol 3350 provides a gentler, osmotic mechanism that softens stool without inducing intestinal cramping. Unlike bulk‑forming agents, it does not rely on fiber fermentation. Its electrolyte‑balanced formulation can be advantageous over plain polyethylene glycol solutions for patients needing additional sodium, potassium or chloride.

Keep the powder in its original, tightly sealed container at ambient temperature, away from direct sunlight and moisture. Protect the package from excessive heat and humidity to maintain product stability. Do not store in the refrigerator or freezer.

Laxido Orange is supplied as a powder that is dissolved in water or another suitable clear fluid according to the instructions on the label. The solution should be mixed thoroughly and consumed promptly after preparation. It is taken orally, usually once daily or as directed by the prescriber.

Although uncommon, serious adverse events can include severe dehydration, significant electrolyte disturbances such as hyponatremia or hypokalemia, and allergic reactions ranging from rash to anaphylaxis. Patients experiencing intense abdominal pain, persistent diarrhea, or signs of an allergic response should seek medical attention immediately.

Laxido Orange is contraindicated in individuals with known or suspected mechanical intestinal obstruction, perforated bowel, or severe inflammatory bowel disease. Patients with severe renal impairment should avoid use unless specifically advised by a physician. It should also be used with caution in the elderly and those with electrolyte disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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