Product image of Laxiriva (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Laxiriva

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Laxiriva (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Sodium hydrogen carbonate, potassium chloride, sodium chloride, and macrogol 3350, the active ingredients in Laxiriva, are laxatives presented as an oral formulation for oral use. It helps relieve occasional constipation and can be used for bowel cleansing in adults.
GNH India supplies Laxiriva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz A/S

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Indications & Clinical Uses

Laxiriva is an oral osmotic laxative used to manage conditions affecting bowel motility and stool consistency.

  • Constipation: softens stool and promotes regular bowel movements.
  • Bowel preparation: facilitates colon cleansing before diagnostic procedures such as colonoscopy.
  • Irritable bowel syndrome with constipation: improves stool frequency and reduces discomfort.

How It Works

  • Laxiriva works by increasing the osmotic load within the intestinal lumen. Macrogol 3350, together with sodium hydrogen carbonate, potassium chloride and sodium chloride, draws water into the bowel, softening stool and enhancing peristaltic activity, thereby facilitating evacuation without stimulating intestinal secretions directly.

Side Effects

Laxiriva may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating: feeling of fullness or swelling in the abdomen.
  • Flatulence: increased intestinal gas.
  • Nausea: mild sensation of wanting to vomit.
  • Mild abdominal cramping: intermittent stomach discomfort.
  • Diarrhoea: loose or watery stools.
  • Electrolyte imbalance: mild changes in sodium or potassium levels.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Severe abdominal pain: intense, persistent pain.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Significant electrolyte disturbances: may lead to cardiac arrhythmia.
  • Rectal bleeding: unusual blood in stool.

Precautions & Warnings

Before using Laxiriva, consider the following safety measures.

  • Assess renal function: impaired kidneys may affect electrolyte handling.
  • Monitor electrolyte balance: especially in patients on diuretics or with cardiac disease.
  • Use with caution in the elderly: higher risk of dehydration.
  • Avoid in complete bowel obstruction: may worsen blockage.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Laxiriva can interact with other medicines, requiring attention to avoid complications.

Major Interactions (Avoid)

  • Concurrent osmotic laxatives: risk of severe electrolyte loss.
  • Loop diuretics: increased risk of dehydration and electrolyte depletion.
  • Lithium therapy: altered lithium plasma concentrations.
  • Anticholinergic agents: reduced laxative efficacy.

Moderate Interactions (Monitor Closely)

  • NSAIDs: potential impact on renal function when combined.
  • ACE inhibitors or ARBs: monitor kidney function and electrolytes.

Frequently Asked Questions

Laxiriva is an oral laxative indicated for the relief of occasional constipation and for bowel cleansing before diagnostic procedures such as colonoscopy. It works by softening stool and promoting regular bowel movements.

The formulation contains macrogol 3350 together with sodium hydrogen carbonate, potassium chloride and sodium chloride. These components increase the osmotic pressure in the intestinal lumen, drawing water into the bowel, softening stool and stimulating peristalsis to facilitate evacuation.

The appropriate dose of Laxiriva is determined by the prescribing healthcare professional based on the individual’s condition, age, and response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Laxiriva in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using this product.

To place an order, submit an enquiry on the Laxiriva product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Laxiriva is an osmotic laxative that softens stool by drawing water into the intestine, whereas stimulant laxatives act by increasing intestinal motility. Compared with stimulant agents, Laxiriva generally has a gentler onset and a lower risk of cramping, making it suitable for routine constipation management.

Laxiriva should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Laxiriva is taken orally, usually dissolved in a specified volume of water as directed by the prescriber. It should be consumed with a full glass of water and may be taken with or without food, following the healthcare professional’s guidance.

Serious risks include severe dehydration, significant electrolyte disturbances that can affect heart rhythm, and rare allergic reactions such as rash, swelling or breathing difficulties. Patients should seek medical attention promptly if they experience any of these symptoms.

Laxiriva should be avoided in individuals with known hypersensitivity to any of its components, in cases of complete bowel obstruction, and in patients with severe renal impairment without medical supervision. A healthcare professional should evaluate suitability before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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