Product image of Laxoberal (Sodium Picosulfate) supplied by GNH India

Laxoberal

Active Ingredient:
Sodium Picosulfate
Origin:
EU

Laxoberal (Sodium Picosulfate)

Sodium Picosulfate, the active ingredient in Laxoberal, is a stimulant laxative presented as an oral tablet for oral use. It treats occasional constipation and is employed to cleanse the bowel before diagnostic procedures such as colonoscopy. The formulation is designed for rapid onset of action and is widely accepted in European markets.

GNH India supplies Laxoberal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets. The company follows stringent quality‑assurance protocols and provides reliable logistics support for global distribution.

Manufacturer / TM Owner

Opella Healthcare France Sas

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Indications & Clinical Uses

Sodium picosulfate is a stimulant laxative that increases intestinal motility and fluid secretion.

  • Occasional constipation: promotes regular bowel movements in individuals with infrequent stools.
  • Colonoscopy preparation: clears the colon to allow optimal visualisation during colonoscopic examination.
  • Diagnostic procedure preparation: facilitates bowel cleansing before procedures such as sigmoidoscopy or radiographic studies.

How It Works

  • Sodium picosulfate is a pro‑drug that is minimally active after oral ingestion. In the colon, bacterial enzymes convert it to the active metabolite, which stimulates enteric nerves, enhancing peristaltic activity and promoting secretion of water and electrolytes into the lumen, thereby accelerating stool transit and evacuation. The effect is localized to the large intestine, with minimal systemic absorption, resulting in a targeted laxative action.

Side Effects

Sodium picosulfate may cause a range of adverse reactions, most of which are related to its laxative activity.

Common Side Effects

  • Abdominal cramps: discomfort due to increased colonic activity.
  • Diarrhea: loose stools resulting from accelerated transit.
  • Nausea: mild stomach upset in some patients.
  • Flatulence: excess gas production.
  • Urgency to defecate: sudden need to pass stool.
  • Mild electrolyte imbalance: transient changes in sodium or potassium levels.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Significant electrolyte disturbances: such as hypokalemia.
  • Rectal bleeding: uncommon but may indicate mucosal irritation.
  • Allergic reactions: rash, itching, or angioedema in sensitive individuals.

Precautions & Warnings

Before using Laxoberal, consider the following precautions.

  • Assess bowel function before use: confirm the patient has not had a recent bowel movement.
  • Avoid use in patients with intestinal obstruction: contraindicated due to risk of perforation.
  • Use with caution in elderly: increased risk of dehydration and electrolyte loss.
  • Do not combine with other stimulant laxatives: may amplify adverse gastrointestinal effects.
  • Pregnancy and lactation: safety not established; consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Sodium picosulfate can interact with several medication classes.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce the laxative efficacy.
  • Opioid analgesics: can counteract stimulant effects on bowel motility.
  • Magnesium‑containing antacids: may cause excessive electrolyte shifts.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor for dehydration and electrolyte imbalance.
  • Cardiac glycosides: watch for hypokalemia which can affect cardiac function.
  • Other laxatives: concurrent use increases risk of fluid loss and electrolyte disturbances.

Frequently Asked Questions

Laxoberal contains sodium picosulfate, an over‑the‑counter stimulant laxative indicated for occasional constipation and for bowel cleansing before diagnostic procedures such as colonoscopy. It works by stimulating colonic peristalsis and increasing fluid secretion to promote evacuation.

Sodium picosulfate is a pro‑drug that is activated by colonic bacteria into a compound that stimulates the enteric nervous system. This increases peristaltic contractions and fluid secretion in the large intestine, leading to faster stool passage and bowel evacuation.

The dose of Laxoberal is determined by the prescribing healthcare professional based on the indication, patient age, and clinical condition. The product is supplied as an oral tablet, and the prescriber provides specific instructions regarding the number of tablets and timing.

The safety of sodium picosulfate during pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk, and only under the guidance of a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Unlike osmotic agents such as polyethylene glycol, sodium picosulfate acts as a stimulant, producing a quicker onset of bowel movement but may be associated with more abdominal cramping. It is often preferred for bowel preparation because of its predictable cleansing effect.

Store at ambient temperature, preferably below 25 °C, in the original packaging. Protect the tablets from moisture, direct sunlight and excessive heat to maintain potency throughout the shelf life.

Laxoberal is taken orally, usually with a full glass of water. For bowel preparation, the tablets are often divided into two doses taken several hours apart, but the exact regimen should follow the prescribing clinician’s directions.

The most serious risks include severe dehydration, significant electrolyte disturbances such as hypokalemia, and rare cases of rectal bleeding. Patients should monitor for excessive fluid loss, dizziness, muscle weakness, or blood in the stool and seek medical attention promptly.

Laxoberal should be avoided in individuals with known or suspected intestinal obstruction, active inflammatory bowel disease flare, acute abdominal pain of unknown cause, or hypersensitivity to sodium picosulfate. It is also contraindicated in patients who have recently used other stimulant laxatives.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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