Product image of Laxogol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Laxogol

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Laxogol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Laxogol, is an osmotic laxative presented as an oral powder for oral use. It softens stool and promotes regular bowel movements, helping relieve constipation and preparing the bowel for diagnostic procedures in adults and children as directed by a healthcare professional.

GNH India supplies Laxogol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution, ensuring product integrity from manufacture to delivery.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

  • Laxogol, an osmotic laxative, acts on the gastrointestinal tract to alleviate constipation and to prepare the bowel for procedures.
  • Constipation: softens stool and increases water content to facilitate regular bowel movements.
  • Bowel preparation for colonoscopy: clears the intestinal lumen to improve visualization during the procedure.
  • Bowel preparation for radiologic imaging: empties the colon to enhance image quality for contrast studies.

How It Works

  • Macrogol 3350 creates an osmotic gradient within the intestinal lumen by retaining water molecules, while the accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain electrolyte balance. The increased intraluminal water softens fecal mass and expands stool volume, stimulating peristalsis and promoting evacuation without stimulating intestinal secretions. This mechanism leads to a gentle, non‑stimulatory laxative effect suitable for short‑term use.

Side Effects

Laxogol may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Mild diarrhea

Serious or Rare Side Effects

  • Severe electrolyte imbalance (e.g., hyperkalemia)
  • Allergic reaction such as rash or anaphylaxis
  • Severe abdominal pain or rectal bleeding

Precautions & Warnings

  • When using Laxogol, certain precautions should be observed to minimize risks.
  • Assess renal function: evaluate kidney status before initiating therapy in patients with known renal impairment.
  • Monitor electrolytes: check serum potassium and sodium levels during prolonged use due to electrolyte content.
  • Avoid in complete intestinal obstruction: the product should not be used when bowel blockage is present.
  • Use with caution in the elderly: increased susceptibility to dehydration and electrolyte shifts.
  • Pregnancy and lactation: consult a healthcare professional before use, as safety data are limited.
  • Store at ambient temperature: keep the powder in its original container, protect from moisture and heat.

Avoid Interactions

Laxogol can interact with other medications, affecting electrolyte balance or fluid status.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium supplements: may cause hyperkalemia.
  • Use with other osmotic laxatives: increases risk of severe electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate fluid loss and electrolyte depletion.
  • ACE inhibitors or ARBs: monitor potassium levels due to combined effect on serum potassium.
  • Antacids containing sodium: may increase sodium load and affect fluid balance.

Frequently Asked Questions

Laxogol is an oral osmotic laxative indicated for the relief of occasional constipation and for bowel preparation before diagnostic procedures such as colonoscopy or radiologic imaging. It works by increasing the water content of stool, making evacuation easier and helping to clear the intestinal tract.

Macrogol 3350, the primary osmotic agent in Laxogol, retains water within the intestinal lumen, creating an osmotic gradient that softens stool and expands its volume. The added electrolytes help maintain fluid balance while the increased intraluminal water stimulates gentle peristalsis, facilitating bowel movements without stimulating secretions.

The appropriate dose of Laxogol is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of constipation, and the specific bowel‑preparation protocol required. Dosing instructions are individualized and should be followed exactly as written on the prescription label.

Safety data for Laxogol in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the medication.

To order Laxogol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Laxogol contains macrogol 3350 together with balanced electrolytes, which can provide a more controlled fluid and electrolyte profile compared with plain polyethylene glycol formulations. This combination may reduce the risk of electrolyte imbalance in some patients, while offering similar efficacy in stool softening and bowel cleansing.

Laxogol should be stored at ambient temperature, below 25 °C, in its original packaging. The container should be kept tightly closed, protected from moisture, direct sunlight and excessive heat to maintain product stability and potency.

Laxogol is taken orally, typically as a powder that is dissolved in water or another suitable liquid according to the prescriber’s instructions. The solution is consumed at the time and dosage specified on the prescription, and patients should follow any additional guidance regarding fluid intake.

The most serious risks include severe electrolyte disturbances such as hyperkalemia or hyponatremia, significant dehydration, and allergic reactions that may present as rash, swelling or anaphylaxis. If any of these symptoms occur, medical attention should be sought immediately.

Laxogol should be avoided in individuals with a known complete intestinal obstruction, severe renal impairment, or hypersensitivity to any of its ingredients. It is also contraindicated in patients for whom electrolyte balance cannot be monitored, and use should be carefully considered in the elderly and in those with chronic dehydration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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