Product image of Laxose (Lactulose) supplied by GNH India

Laxose

Active Ingredient:
Lactulose
Origin:
EU

Laxose (Lactulose)

Lactulose, the active ingredient in Laxose, is an osmotic laxative presented as an oral formulation for oral use. It treats constipation and hepatic encephalopathy by softening stools and reducing blood ammonia levels. Laxose is supplied for adult and pediatric patients requiring these therapeutic effects.

GNH India supplies Laxose as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pinewood Laboratories Limited

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Indications & Clinical Uses

Laxose is an osmotic laxative that acts on the gastrointestinal tract to relieve bowel dysfunction and on hepatic metabolism to lower ammonia.

  • Constipation (adults): softens stools and promotes regular bowel movements.
  • Constipation (pediatric): provides gentle relief of chronic constipation in children.
  • Hepatic encephalopathy: lowers intestinal ammonia production, helping improve mental status in liver disease patients.

How It Works

  • Lactulose is a synthetic disaccharide that is not absorbed in the small intestine. In the colon it is metabolised by bacterial flora into short‑chain fatty acids, increasing osmotic pressure and drawing water into the lumen, which softens stool. The acidic environment also converts ammonia to ammonium, trapping it in the colon and reducing systemic ammonia levels.

Side Effects

Laxose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Flatulence: increased intestinal gas production.
  • Abdominal cramps: mild to moderate discomfort.
  • Diarrhoea: loose stools, especially with higher doses.
  • Nausea: occasional feeling of queasiness.
  • Increased stool frequency: more frequent bowel movements.
  • Borborygmi: audible intestinal rumbling.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Electrolyte imbalance: abnormal sodium or potassium levels.
  • Allergic reaction: rash, itching, or swelling.
  • Severe abdominal pain: persistent or worsening pain.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: monitor patients with severe renal impairment for electrolyte disturbances.
  • Fluid intake: ensure adequate hydration to reduce risk of dehydration.
  • Diabetes monitoring: lactulose contains small amounts of sugar; observe blood glucose levels.
  • Galactosemia avoidance: product contains lactose, contraindicated in galactose‑intolerant individuals.
  • Pregnancy and lactation: use only if the prescriber determines benefits outweigh potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Laxose can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Antibiotics (e.g., rifaximin): may reduce lactulose's ammonia‑lowering effect.
  • Other laxatives (e.g., bisacodyl): additive laxative action can cause severe diarrhoea.
  • Antidiarrhoeal agents (e.g., loperamide): may counteract lactulose's intended effect.

Moderate Interactions (Monitor Closely)

  • Mineral supplements (e.g., calcium carbonate): may affect lactulose metabolism.
  • Oral hypoglycaemic agents: monitor glucose as lactulose can influence carbohydrate absorption.
  • Diuretics: watch for electrolyte disturbances when combined with lactulose.

Frequently Asked Questions

Laxose contains lactulose, an osmotic laxative indicated for the relief of constipation and for the management of hepatic encephalopathy in patients with liver disease. It works by drawing water into the colon to soften stools and by reducing intestinal ammonia production, which helps improve neurological symptoms.

Lactulose is a synthetic sugar that reaches the colon unchanged, where gut bacteria ferment it into short‑chain fatty acids. This fermentation lowers colonic pH, increasing osmotic pressure and pulling water into the lumen, which softens stool. The acidic environment also converts ammonia to ammonium, trapping it in the colon and lowering blood ammonia levels.

The dose of Laxose is individualized by the prescribing healthcare professional based on the patient’s age, weight, renal function, and the specific indication. The prescriber determines the appropriate amount and frequency to achieve the desired therapeutic effect while minimizing adverse reactions.

Safety data for lactulose in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should evaluate the clinical situation and discuss potential risks before prescribing Laxose to pregnant or nursing individuals.

To order Laxose, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and required import documentation.

Laxose (lactulose) is an osmotic laxative that works by increasing water content in the colon, whereas agents such as polyethylene glycol (PEG) also draw water but differ in taste, formulation and dosing frequency. Lactulose additionally lowers ammonia levels, making it useful for hepatic encephalopathy—a benefit not shared by most other laxatives.

Store Laxose at room temperature, below 25 °C, in its original container. Protect it from moisture, direct sunlight and extreme heat. Keep the product out of reach of children and avoid using it after the expiry date printed on the label.

Laxose is taken orally, usually as a liquid that can be measured with a calibrated spoon or cup. It may be mixed with a small amount of water, juice or milk to improve palatability. The dose is taken once or twice daily as directed by the prescriber, with or without food.

Serious risks include severe dehydration and electrolyte imbalances, particularly sodium or potassium disturbances, which can occur with excessive diarrhoea. Rarely, patients may experience allergic reactions such as rash, itching or swelling, and severe abdominal pain that warrants immediate medical evaluation.

Laxose should be avoided in individuals with known hypersensitivity to lactulose, those with galactosemia due to its lactose content, and patients with severe renal impairment where electrolyte disturbances are a concern. It is also contraindicated in cases of intestinal obstruction or perforation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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