Product image of Laxygal (Sodium Picosulfate Monohydrate) supplied by GNH India

Laxygal

Active Ingredient:
Sodium Picosulfate Monohydrate
Origin:
EU

Laxygal (Sodium Picosulfate Monohydrate)

Sodium picosulfate, the active ingredient in Laxygal, is a stimulant laxative presented as an oral preparation for oral use. It treats constipation and is employed for bowel preparation before colonoscopy in adult patients.

GNH India supplies Laxygal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Laxygal (sodium picosulfate) is a stimulant laxative used to manage conditions affecting colonic transit.

  • Constipation: facilitates bowel movements by increasing intestinal peristalsis and water content.
  • Bowel preparation for colonoscopy: clears the colon to allow clear visualization during the procedure.
  • Pre‑surgical bowel cleansing: prepares the colon before certain abdominal surgeries to reduce fecal load.

How It Works

  • Sodium picosulfate is a pro‑drug that reaches the colon unchanged, where colonic bacteria convert it to an active metabolite. The metabolite stimulates the enteric nerves, enhancing peristaltic activity and promoting secretion of water and electrolytes into the lumen, thereby softening stool and accelerating transit.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Abdominal cramps: mild to moderate discomfort in the abdomen.
  • Diarrhea: increased loose stools.
  • Nausea: feeling of queasiness.
  • Flatulence: excess gas production.
  • Thirst: increased desire for fluids.
  • Electrolyte imbalance: mild changes in serum electrolytes.

Serious or Rare Side Effects

  • Severe dehydration: marked loss of body fluids.
  • Significant electrolyte disturbances: notable shifts in potassium or sodium levels.
  • Allergic reaction: rash, itching, or swelling.
  • Colitis: inflammation of the colon.
  • Rectal bleeding: presence of blood in stool.
  • Severe abdominal pain: intense, persistent pain.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess bowel function: ensure patient is not already experiencing obstruction.
  • Avoid use in intestinal blockage: contraindicated in mechanical obstruction.
  • Caution with electrolyte disorders: monitor serum electrolytes in at‑risk patients.
  • Pediatric use: limit to children only under medical supervision.
  • Concomitant laxatives: do not combine with other stimulant or osmotic laxatives.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Drug interactions may alter efficacy or safety.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce laxative effect.
  • Opioid analgesics: counteract stimulant action on the colon.
  • Mineral oil: can impair absorption of the drug.

Moderate Interactions (Monitor Closely)

  • Diuretics: increase risk of electrolyte imbalance.
  • Cardiac glycosides: electrolyte changes may affect cardiac function.
  • Antacids: may alter colonic pH and affect drug activation.

Frequently Asked Questions

Laxygal contains sodium picosulfate, a stimulant laxative indicated for relieving occasional constipation and for bowel cleansing before colonoscopy or certain abdominal surgeries. It works by stimulating colonic motility and increasing fluid secretion to produce a complete evacuation of the intestine.

Sodium picosulfate is a pro‑drug that is metabolized by colonic bacteria into an active compound. This metabolite activates enteric nerves, enhancing peristalsis and promoting secretion of water and electrolytes into the intestinal lumen, which softens stool and accelerates its passage.

The appropriate dose of Laxygal is determined by the prescribing healthcare professional based on the patient’s condition, age, and response. Dosage instructions are provided on the product label and must be followed exactly as directed by the prescriber.

Safety data for sodium picosulfate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Laxygal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with osmotic laxatives such as polyethylene glycol, sodium picosulfate acts as a stimulant, producing a quicker onset of bowel movements. It is often preferred for bowel preparation because it requires a smaller volume of fluid, but individual response and tolerability may vary.

Laxygal should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Laxygal is taken orally, usually with a specified amount of water as directed by the prescriber. The tablets or granules are swallowed whole; they should not be chewed, crushed, or dissolved unless the label specifically permits it.

Serious risks include severe dehydration, marked electrolyte disturbances (especially low potassium), and rare allergic reactions. Patients should seek immediate medical attention if they experience persistent diarrhea, dizziness, fainting, or signs of an allergic response.

Laxygal should be avoided in individuals with known or suspected intestinal obstruction, acute abdominal pain of unknown cause, severe inflammatory bowel disease, or hypersensitivity to sodium picosulfate. It is also contraindicated in patients for whom electrolyte balance cannot be safely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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