Product image of Lazap (Olanzapine) supplied by GNH India

Lazap

Active Ingredient:
Olanzapine
Origin:
EU

Lazap (Olanzapine)

Olanzapine, the active ingredient in Lazap, is an atypical antipsychotic presented as an oral tablet for oral use. It is prescribed for the management of schizophrenia and bipolar disorder in adult patients.
GNH India supplies Lazap as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Brain Therapeutics Μονοπροσωπη Ικε

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Indications & Clinical Uses

Olanzapine acts on central neurotransmitter pathways to treat serious mental health conditions.

  • Schizophrenia: alleviates psychotic symptoms such as delusions, hallucinations and thought disorder.
  • Bipolar disorder: stabilises mood and reduces the frequency of manic and depressive episodes.

How It Works

  • Olanzapine exerts its therapeutic effect by antagonising dopamine D2 receptors and serotonin 5‑HT2A receptors, while also modulating activity at histamine H1, muscarinic and adrenergic receptors. This receptor profile reduces dopaminergic and serotonergic neurotransmission implicated in psychosis and mood dysregulation.

Side Effects

Olanzapine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Weight gain: increased appetite leading to noticeable weight increase.
  • Sedation: drowsiness or feeling unusually tired.
  • Dry mouth: reduced salivation causing oral discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: light‑headedness, especially when standing quickly.
  • Increased appetite: heightened desire for food.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells.
  • Hyperglycemia: marked elevation of blood sugar levels.
  • Seizures: occurrence of convulsive episodes.
  • Tardive dyskinesia: involuntary, repetitive movements.
  • Myocarditis: inflammation of the heart muscle.

Precautions & Warnings

When prescribing or dispensing Olanzapine, consider the following safety measures.

  • Monitor metabolic parameters: regularly assess weight, glucose and lipid levels.
  • Assess for cardiovascular risk: evaluate blood pressure and lipid profile before initiation.
  • Evaluate hepatic function: adjust use in patients with liver impairment.
  • Review psychiatric history: be cautious in patients with a history of suicidal ideation.
  • Avoid abrupt discontinuation: taper dose under medical supervision to prevent relapse.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Olanzapine can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise olanzapine plasma concentrations.
  • CNS depressants (e.g., benzodiazepines): additive sedation and respiratory depression.
  • Anticholinergic agents: increased anticholinergic burden leading to confusion.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers (e.g., smoking, carbamazepine): may lower olanzapine levels.
  • Antihypertensives: potential enhancement of hypotensive effect.
  • Lithium: may increase risk of neurotoxicity when combined.

Frequently Asked Questions

Lazap contains olanzapine, an atypical antipsychotic indicated for the treatment of schizophrenia and for the management of manic or mixed episodes in bipolar disorder. It helps control psychotic symptoms and stabilises mood in adult patients.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors in the brain, which reduces excessive dopaminergic and serotonergic activity linked to psychosis and mood swings. Its additional activity at histamine, muscarinic and adrenergic receptors contributes to its overall therapeutic profile.

The appropriate dose of Lazap is determined individually by a qualified prescriber based on the patient’s clinical condition, response to therapy and tolerability. Dosage may be adjusted over time, and patients should follow the prescribing information provided by their healthcare professional.

Data on olanzapine use in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy or breastfeeding should discuss risks and alternatives with their physician.

To order Lazap, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other atypical antipsychotics such as risperidone or quetiapine, olanzapine often shows strong efficacy in controlling psychotic symptoms but is associated with a higher propensity for metabolic side effects like weight gain and glucose elevation. Choice of therapy depends on individual patient factors and risk‑benefit assessment.

Lazap tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.

Lazap is taken orally as a tablet. The tablet should be swallowed whole with water, preferably at the same time each day. Patients should not crush, split or chew the tablet unless specifically instructed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, severe hyperglycemia, seizures, tardive dyskinesia and myocarditis. Patients should be educated to seek immediate medical attention if they experience high fever, muscle rigidity, unexplained infections, rapid weight gain, or involuntary movements.

Lazap is contraindicated in individuals with known hypersensitivity to olanzapine or any of its excipients. Caution is advised for patients with uncontrolled diabetes, severe cardiovascular disease, hepatic impairment, or a history of neuroleptic malignant syndrome. Pregnant or breastfeeding women should only use it after thorough risk assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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