Product image of Lazapir (Olanzapine) supplied by GNH India

Lazapir

Active Ingredient:
Olanzapine
Origin:
EU

Lazapir (Olanzapine)

Olanzapine, the active ingredient in Lazapir, is an atypical antipsychotic presented as an oral formulation for oral use. It is indicated for the treatment of schizophrenia and bipolar disorder in adults.

GNH India supplies Lazapir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Italy Spa

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic that modulates dopamine and serotonin pathways in major psychiatric disorders.

  • Schizophrenia: reduces psychotic symptoms and relapse risk.
  • Bipolar disorder (manic episodes): controls elevated mood, agitation and impulsivity.
  • Bipolar disorder (maintenance): helps maintain mood stability and prevent recurrence.
  • Schizoaffective disorder: treats both psychotic and mood components.

How It Works

  • Olanzapine acts primarily as an antagonist at dopamine D2 and serotonin 5‑HT2A receptors, while also influencing other neurotransmitter systems such as histamine H1, muscarinic, and adrenergic receptors. This receptor profile reduces dopaminergic and serotonergic over‑activity, contributing to its antipsychotic and mood‑stabilising effects.

Side Effects

Olanzapine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Weight gain: increased appetite leading to noticeable weight increase.
  • Sedation: drowsiness or feeling unusually sleepy.
  • Dry mouth: reduced salivation causing oral discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Increased appetite: heightened desire for food.
  • Dizziness: light‑headedness, especially when standing quickly.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe drop in white blood cells increasing infection risk.
  • Hyperglycemia: marked increase in blood sugar levels, may precipitate diabetes.
  • Tardive dyskinesia: involuntary movements of facial muscles and tongue.
  • Seizures: occurrence of convulsive episodes.
  • Myocarditis: inflammation of heart muscle, rare but serious.

Precautions & Warnings

When prescribing Olanzapine, clinicians should consider several safety precautions.

  • Pregnancy: limited data; use only if potential benefit justifies risk.
  • Breastfeeding: assess risk; drug may pass into milk.
  • Metabolic monitoring: regularly check weight, glucose and lipid levels.
  • Elderly patients: increased sensitivity to sedation and fall risk.
  • Driving and operating machinery: may cause drowsiness; advise caution.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Olanzapine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise olanzapine plasma concentrations.
  • CYP1A2 inducers (e.g., smoking, carbamazepine): may lower olanzapine levels.
  • CNS depressants (e.g., benzodiazepines, alcohol): can cause excessive sedation.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: olanzapine may impair glucose control.
  • Antihypertensives: additive hypotensive effect possible.
  • Lithium: monitor for signs of neurotoxicity.
  • Anticholinergic drugs: may increase anticholinergic burden.
  • Antihistamines: may enhance sedation.

Frequently Asked Questions

Lazapir contains olanzapine, an atypical antipsychotic indicated for the management of schizophrenia and for treating manic episodes and maintenance therapy in bipolar disorder. It helps control psychotic symptoms, mood swings, and can reduce the risk of relapse when used as part of a comprehensive treatment plan.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors, which moderates neurotransmission linked to psychosis and mood disturbances. Its additional activity at histamine, muscarinic and adrenergic receptors contributes to its overall therapeutic profile, helping to stabilize mood and reduce hallucinations or delusions.

The appropriate dose of Lazapir is individualized by the prescribing clinician based on the patient’s diagnosis, severity of symptoms, prior treatment response, age, liver function and any concomitant medications. Dosage adjustments are made according to clinical response and tolerability, following local prescribing guidelines.

Safety data for olanzapine in pregnancy are limited; it should only be used when the potential benefit outweighs any risk to the fetus. During breastfeeding, olanzapine can be excreted in breast milk, so a risk‑benefit assessment is required. Healthcare providers should discuss alternatives and monitoring strategies with the patient.

To order Lazapir, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lazapir (olanzapine) is known for strong efficacy in controlling both psychotic and manic symptoms, but it is also associated with a higher propensity for metabolic side effects such as weight gain and glucose elevation compared with some other atypicals. Choice of therapy depends on individual patient factors, efficacy needs and tolerability considerations.

Lazapir should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from excess moisture, light and heat. Do not store in bathrooms or near windows where temperature fluctuations may occur.

Lazapir is taken orally, usually as a tablet or other solid oral dosage form, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, severe hyperglycemia, tardive dyskinesia, seizures and myocarditis. Patients should be monitored for fever, muscle rigidity, sudden changes in blood counts, blood sugar spikes, involuntary movements or cardiac symptoms, and seek immediate medical attention if they occur.

Lazapir is contraindicated in individuals with known hypersensitivity to olanzapine or any of its excipients. Caution is advised for patients with uncontrolled diabetes, severe cardiovascular disease, a history of neuroleptic malignant syndrome, or those taking medications that strongly interact with olanzapine metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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