Product image of Lazinamo (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Lazinamo

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Lazinamo (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride and fluticasone propionate, the active ingredients in Lazinamo, are an antihistamine and a corticosteroid presented as a nasal spray for nasal use. They treat allergic rhinitis, including seasonal and perennial forms, by reducing histamine‑mediated symptoms and nasal inflammation.

GNH India supplies Lazinamo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

Lazinamo combines an antihistamine and a corticosteroid to address allergic airway inflammation.

  • Allergic rhinitis (seasonal): reduces sneezing, itching, and rhinorrhea associated with seasonal allergens.
  • Allergic rhinitis (perennial): alleviates chronic nasal congestion and discharge caused by year‑round allergens.
  • Nasal congestion due to allergic inflammation: decreases mucosal edema and improves airflow.

How It Works

  • Azelastine hydrochloride selectively blocks H1‑histamine receptors, preventing histamine‑induced vasodilation and sensory nerve activation. Fluticasone propionate binds glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokine production, reduce vascular permeability, and limit nasal mucosal edema, together providing rapid symptom relief and longer‑term control of allergic inflammation.

Side Effects

Lazinamo may cause local and systemic reactions typical of intranasal antihistamine‑corticosteroid combinations.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Bitter taste after administration
  • Mild epistaxis (nosebleed)
  • Throat irritation or cough

Serious or Rare Side Effects

  • Nasal septal perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes or ocular pressure increase
  • Adrenal suppression with prolonged high‑dose use
  • Fungal sinusitis or secondary infection
  • Profound or persistent nosebleeds

Precautions & Warnings

Before using Lazinamo, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Concomitant nasal surgery: postpone treatment until the surgical site has healed.
  • Pediatric use: follow pediatric guidance; safety not established for very young children.
  • Hypersensitivity: avoid if known allergy to azelastine, fluticasone, or any formulation components.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lazinamo can interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase fluticasone exposure.
  • Live vaccines: systemic corticosteroid effect may reduce vaccine efficacy.
  • MAO inhibitors: potential additive antihistamine effects.

Moderate Interactions (Monitor Closely)

  • Other intranasal decongestants: risk of increased nasal irritation.
  • Oral antihistamines: may enhance sedation.
  • Antifungal azoles: may affect fluticasone metabolism.

Frequently Asked Questions

Lazinamo is a nasal spray that combines azelastine hydrochloride and fluticasone propionate to treat allergic rhinitis—both seasonal and perennial—and to relieve nasal congestion caused by allergic inflammation.

Azelastine hydrochloride is a selective H1‑receptor antagonist; it blocks histamine binding at nasal mucosal receptors, reducing symptoms such as sneezing, itching, and watery discharge.

The prescribed dose of Lazinamo is determined by a qualified healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the prescriber’s instructions.

Safety data for Lazinamo in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To order Lazinamo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lazinamo combines an antihistamine (azelastine) with a corticosteroid (fluticasone) in a single spray, offering both rapid symptom relief and anti‑inflammatory action. Single‑component sprays provide either antihistamine or steroid effects, while Lazinamo delivers the benefits of both classes together.

Store Lazinamo at room temperature, below 25 °C. Keep the spray in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed when not in use.

Lazinamo is administered as a nasal spray. The patient tilts the head slightly forward, inserts the nozzle into each nostril, and sprays the prescribed number of sprays while breathing in gently. Detailed instructions are provided by the prescribing clinician.

Serious risks, though uncommon, include nasal septal perforation, severe allergic reactions such as anaphylaxis, significant nosebleeds, and potential adrenal suppression with prolonged high‑dose use. Any concerning symptoms should prompt immediate medical evaluation.

Lazinamo should be avoided by individuals with known hypersensitivity to azelastine, fluticasone, or any excipients in the formulation. Patients with recent nasal surgery or severe nasal trauma should also consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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