Product image of Lecalcif (Colecalciferol) supplied by GNH India

Lecalcif

Active Ingredient:
Colecalciferol
Origin:
EU

Lecalcif (Colecalciferol)

Colecalciferol, the active ingredient in Lecalcif, is a Vitamin D3 presented as an oral supplement for oral use. It is used to treat vitamin D deficiency, hypocalcemia and to support bone health in adults and children.

GNH India supplies Lecalcif as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

  • Lecalcif (colecalciferol) is used in the management of disorders related to vitamin D deficiency and calcium metabolism.
  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels to support normal bone metabolism.
  • Hypocalcemia: increases calcium absorption to correct low blood calcium concentrations.
  • Bone health support: aids in maintaining bone mineral density and reducing risk of osteomalacia.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D3, which is further hydroxylated in the kidney to the active hormone 1,25‑dihydroxyvitamin D3. The active metabolite binds to intracellular vitamin D receptors, forming a heterodimer with retinoid X receptors that attaches to vitamin D response elements in DNA, thereby enhancing transcription of calcium‑binding proteins such as calbindin, which increase intestinal absorption of calcium and phosphate and promote bone mineralization.

Side Effects

Colecalciferol may cause a range of adverse reactions, most of which are mild and dose‑related.

Common Side Effects

  • Nausea
  • Constipation
  • Headache
  • Dry mouth
  • Mild hypercalcemia (asymptomatic)

Serious or Rare Side Effects

  • Hypervitaminosis D leading to severe hypercalcemia
  • Renal stones
  • Cardiac arrhythmias due to high calcium
  • Severe allergic reactions (anaphylaxis)
  • Hyperphosphatemia

Precautions & Warnings

  • When using Lecalcif, consider the following precautions to ensure safe and effective therapy.
  • Assess baseline serum calcium and 25‑hydroxyvitamin D levels: determine need for supplementation.
  • Monitor for signs of hypercalcemia during therapy: especially in patients with renal disease.
  • Use caution in patients with sarcoidosis or granulomatous diseases: they may have increased conversion to active vitamin D.
  • Avoid concurrent high‑dose calcium or vitamin A supplements without medical supervision.
  • Pregnancy and lactation: use only if clearly needed and prescribed by a healthcare professional.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Colecalciferol can interact with several medicines, altering calcium balance or vitamin D metabolism.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcemia.
  • High‑dose calcium supplements: additive effect on calcium levels.
  • Vitamin A excess: potentiates hypercalcemia.

Moderate Interactions (Monitor Closely)

  • Glucocorticoids: reduce vitamin D effectiveness, may require dose adjustment.
  • Anticonvulsants (e.g., phenytoin, phenobarbital): increase vitamin D catabolism.
  • Bariatric surgery patients: altered absorption may affect efficacy.
  • Bisphosphonates: concurrent use may affect calcium homeostasis.

Frequently Asked Questions

Lecalcif is an oral vitamin D3 (colecalciferol) supplement indicated for the correction of vitamin D deficiency, the management of hypocalcemia, and the general support of bone health in both children and adults.

After oral intake, colecalciferol is hydroxylated in the liver to 25‑hydroxyvitamin D and then in the kidney to the active form 1,25‑dihydroxyvitamin D. This active hormone binds to vitamin D receptors, increasing transcription of calcium‑binding proteins that enhance intestinal calcium and phosphate absorption and promote bone mineralisation.

The appropriate dose of Lecalcif is determined by a qualified healthcare professional based on the patient’s age, serum vitamin D level, underlying condition and individual response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Lecalcif may be used during pregnancy or lactation only when clearly indicated and prescribed by a physician. Limited safety data exist, so the prescriber will weigh potential benefits against any theoretical risks before recommending therapy.

To order Lecalcif, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lecalcif contains colecalciferol, the same active ingredient found in most vitamin D3 preparations. Differences among products are usually related to dosage strength, formulation (tablet, capsule, liquid) and regulatory status, but the pharmacological effect of raising serum vitamin D levels is comparable.

Store Lecalcif at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct light. Keep the container tightly closed and out of reach of children.

Lecalcif is taken orally, with or without food, as directed by the prescribing clinician. Swallow the tablet or capsule whole with a glass of water; do not crush or chew unless the formulation specifically permits it.

The most serious risks include hypervitaminosis D, severe hypercalcemia, renal stone formation, and rare allergic reactions such as anaphylaxis. Patients should seek medical attention if they experience symptoms like persistent nausea, vomiting, excessive thirst, confusion, or muscle weakness.

Lecalcif should be avoided in individuals with known hypersensitivity to colecalciferol or any excipients, in patients with existing hypercalcemia, and in those with granulomatous diseases such as sarcoidosis where vitamin D metabolism is altered, unless a physician decides otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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