Product image of Lecalcif (Colecalciferol) supplied by GNH India

Lecalcif

Active Ingredient:
Colecalciferol
Origin:
EU

Lecalcif (Colecalciferol)

Colecalciferol, the active ingredient in Lecalcif, is a Vitamin D analog presented as a oral dosage form for oral use. It treats vitamin D deficiency and supports bone health in adults and children.

GNH India supplies Lecalcif as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Lecalcif, a vitamin D analog, is used to address disorders of calcium metabolism and bone mineralization.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels.
  • Osteomalacia/rickets prevention: supports normal bone mineralization in at‑risk populations.
  • Bone health support: helps maintain calcium and phosphate balance for skeletal health.

How It Works

  • After oral ingestion, colecalciferol is hydroxylated in the liver to 25‑hydroxyvitamin D and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D. The active form binds the nuclear vitamin D receptor, inducing transcription of calcium‑binding proteins that increase intestinal absorption of calcium and phosphate, thereby enhancing bone mineralization.

Side Effects

Common Side Effects

  • Nausea: mild stomach upset may occur.
  • Constipation: occasional bowel slowing.
  • Headache: transient head discomfort.
  • Dry mouth: reduced salivation.
  • Fatigue: feeling of low energy.
  • Mild hypercalcemia: slight elevation of blood calcium without symptoms.

Serious or Rare Side Effects

  • Severe hypercalcemia: can cause vomiting, arrhythmia, and renal impairment.
  • Hypercalciuria: excess calcium in urine leading to kidney stones.
  • Allergic reaction: rash, itching, or swelling.
  • Hypersensitivity anaphylaxis: rare but life‑threatening.
  • Calcinosis: abnormal calcium deposition in tissues.
  • Renal failure: in extreme cases of prolonged hypercalcemia.

Precautions & Warnings

Before initiating Lecalcif, consider the following precautions:

  • Baseline assessment: check serum calcium and vitamin D levels.
  • Renal function: monitor in patients with kidney disease.
  • Hypercalcemia risk: avoid in individuals with existing high calcium.
  • Pregnancy and lactation: use only if benefit outweighs risk and under medical advice.
  • Drug interactions: review concomitant medications that affect calcium metabolism.
  • Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Major Interactions (Avoid)

  • Thiazide diuretics: may exacerbate hypercalcemia.
  • High‑dose calcium supplements: increase risk of calcium overload.
  • Vitamin A excess: synergistic toxicity.
  • Rifampin: accelerates vitamin D metabolism, reducing efficacy.
  • Anticonvulsants (e.g., phenobarbital): increase vitamin D catabolism.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may impair vitamin D activation.
  • Loop diuretics: can affect calcium balance.
  • Digoxin: heightened risk of arrhythmia with hypercalcemia.
  • Bisphosphonates: concurrent use may alter calcium dynamics.
  • Cholestyramine: may reduce absorption of vitamin D.

Frequently Asked Questions

Lecalcif contains colecalciferol, a form of vitamin D3, and is used to treat vitamin D deficiency, prevent osteomalacia or rickets, and support overall bone health by ensuring adequate calcium and phosphate absorption.

After ingestion, colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds the nuclear vitamin D receptor, stimulating production of calcium‑binding proteins that increase intestinal calcium and phosphate uptake.

The prescribed dose of Lecalcif is individualized by a healthcare professional based on the patient’s serum vitamin D level, age, weight, and clinical condition. Dosage may range from low maintenance to higher therapeutic amounts, and the prescriber determines the appropriate regimen.

Safety data for colecalciferol in pregnancy and lactation are limited. It should only be used when the potential benefit outweighs any possible risk, and under medical supervision. Pregnant or nursing individuals should consult their healthcare provider before starting Lecalcif.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lecalcif provides colecalciferol, the natural form of vitamin D3, which is generally preferred over vitamin D2 (ergocalciferol) due to higher potency and longer duration of action. Compared with prescription calcitriol, colecalciferol requires metabolic activation, offering a safer profile for routine supplementation.

Store Lecalcif at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Lecalcif is taken orally, usually with or without food, as directed by a healthcare professional. The tablet or capsule should be swallowed whole with a glass of water. Patients should follow the prescriber’s instructions regarding timing and frequency.

The most serious risk is hypercalcemia, which can cause nausea, vomiting, weakness, and cardiac arrhythmias. Severe hypercalcemia may lead to kidney stones or renal impairment. Prompt monitoring of serum calcium and vitamin D levels helps mitigate these risks.

Individuals with known hypersensitivity to colecalciferol or any excipients, patients with hypercalcemia, severe renal disease, or granulomatous disorders such as sarcoidosis should avoid Lecalcif unless a physician determines it is safe. Consultation with a healthcare provider is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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