Product image of Lecalcif (Colecalciferol) supplied by GNH India

Lecalcif

Active Ingredient:
Colecalciferol
Origin:
EU

Lecalcif (Colecalciferol)

Colecalciferol, the active ingredient in Lecalcif, is a Vitamin D3 presented as an oral supplement for oral use. It helps correct vitamin D deficiency and supports bone mineralization in individuals at risk of osteomalacia, rickets, or osteoporosis. The formulation provides reliable bioavailability to enhance calcium and phosphate absorption from the gastrointestinal tract.

GNH India supplies Lecalcif as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Lecalcif (colecalciferol) is used in the management of conditions related to inadequate vitamin D status.

  • Vitamin D deficiency: restores normal serum 25‑hydroxyvitamin D levels to support calcium balance.
  • Osteoporosis prevention: contributes to bone mineral density maintenance and reduces fracture risk in at‑risk populations.
  • Rickets: supplies essential vitamin D to promote proper bone growth and mineralization in children.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D, the main circulating form, and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D. The active metabolite binds to vitamin D receptors in intestinal cells, enhancing transcription of calcium‑binding proteins, which increases intestinal absorption of calcium and phosphate, thereby facilitating bone mineralization and remodeling.

Side Effects

Lecalcif may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset reported in some users.
  • Constipation: occasional difficulty with bowel movements.
  • Headache: transient head pain without other neurological signs.
  • Fatigue: feeling of tiredness not linked to other causes.
  • Mild hypercalcemia: slight elevation of blood calcium without symptoms.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Hypercalcemia with symptoms: severe calcium elevation causing nausea, vomiting, polyuria, and cardiac arrhythmias.
  • Nephrolithiasis: formation of kidney stones due to excess calcium.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis in rare cases.

Precautions & Warnings

Before using Lecalcif, consider the following precautions to ensure safe and effective therapy.

  • Baseline assessment: measure serum 25‑hydroxyvitamin D and calcium levels prior to initiation.
  • Monitoring: repeat calcium and vitamin D tests periodically during treatment.
  • Renal impairment: adjust dosage or avoid use in patients with severe kidney disease.
  • Concomitant calcium supplements: limit additional calcium intake to prevent hypercalcemia.
  • Pregnancy and lactation: use only if clearly needed and under medical supervision.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lecalcif can interact with other medicines, altering calcium balance or vitamin D metabolism.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • High‑dose vitamin A: combined excess can cause hypercalcemia.
  • Calcium‑containing antacids: can lead to excessive calcium levels.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): may accelerate vitamin D metabolism, reducing efficacy.
  • Glucocorticoids: can impair vitamin D activation and calcium absorption.
  • Cholesterol‑lowering agents (e.g., cholestyramine, orlistat): may decrease intestinal absorption of vitamin D.
  • Bisphosphonates: concurrent use requires monitoring of calcium status.

Frequently Asked Questions

Lecalcif contains colecalciferol, a form of vitamin D3, and is used to treat or prevent vitamin D deficiency, support bone health, and manage conditions such as osteoporosis, rickets, and osteomalacia. It helps maintain appropriate calcium and phosphate levels in the body.

Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in intestinal cells, stimulating the synthesis of calcium‑binding proteins that increase absorption of calcium and phosphate, essential for bone mineralization.

The dosage of Lecalcif is individualized by a qualified health professional based on the patient’s serum vitamin D level, age, weight, renal function, and clinical condition. The prescriber determines the appropriate strength and duration, and patients should follow the specific instructions provided on the prescription label.

Colecalciferol is generally considered safe in pregnancy and lactation when used at recommended doses, as vitamin D is essential for fetal bone development and maternal health. However, supplementation should only be undertaken under medical supervision to avoid excessive calcium levels, which could pose risks to both mother and infant.

To order Lecalcif, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lecalcif provides colecalciferol, the natural D3 form, which has higher bioavailability and a longer half‑life than vitamin D2 (ergocalciferol). Compared with high‑dose prescription preparations, Lecalcif is an over‑the‑counter product offering flexible dosing, but it may require physician guidance for patients with severe deficiency or comorbidities.

Lecalcif should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or near heat sources, as excessive humidity can affect product stability.

Lecalcif is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet or capsule is swallowed whole with a glass of water. Patients should not crush or chew the dosage form unless specifically instructed, to maintain proper absorption.

The most serious adverse events associated with excessive vitamin D intake are hypercalcemia, which can cause nausea, vomiting, weakness, kidney stones, and cardiac arrhythmias. Rarely, allergic reactions such as rash, swelling, or anaphylaxis may occur. Patients should seek medical attention if they experience these symptoms.

Lecalcif should be avoided or used with caution in individuals with known hypersensitivity to colecalciferol, severe renal impairment, hypercalcemia, or granulomatous diseases such as sarcoidosis that can increase vitamin D activation. Pregnant or breastfeeding women should only use it under medical supervision, and children require pediatric dosing guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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