Product image of Lecalcif (Colecalciferol) supplied by GNH India

Lecalcif

Active Ingredient:
Colecalciferol
Origin:
EU

Lecalcif (Colecalciferol)

Colecalciferol, the active ingredient in Lecalcif, is a Vitamin D3 (secosteroid) presented as an oral supplement for oral use. It treats vitamin D deficiency and supports bone health in individuals at risk of osteomalacia, rickets, or osteoporosis.

GNH India supplies Lecalcif as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Lecalcif, a vitamin D3 preparation, is used to address conditions linked to insufficient vitamin D and impaired bone mineralisation.

  • Vitamin D deficiency: restores normal serum 25‑hydroxyvitamin D levels and improves calcium balance.
  • Osteomalacia / rickets: promotes bone mineralisation and reduces bone pain in children and adults.
  • Osteoporosis: supports bone health and may help reduce fracture risk when combined with other osteoporosis therapies.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in intestinal cells, enhancing transcription of calcium‑binding proteins, which increases intestinal absorption of calcium and phosphate and facilitates bone mineralisation.

Side Effects

Adverse reactions may occur with any vitamin D supplement. Most are mild and reversible.

Common Side Effects

  • Hypercalcaemia: elevated blood calcium levels causing fatigue or nausea.
  • Nausea or vomiting.
  • Constipation.
  • Headache.
  • Dry mouth.
  • Muscle weakness.

Serious or Rare Side Effects

  • Severe hypercalcaemia leading to cardiac arrhythmia.
  • Nephrolithiasis (kidney stones).
  • Acute pancreatitis.
  • Anaphylactic reaction or severe skin rash.
  • Hypercalciuria causing renal impairment.
  • Hyperphosphataemia.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor relevant parameters.

  • Serum calcium assessment: check baseline calcium to avoid hypercalcaemia.
  • Renal function monitoring: evaluate kidney health, especially in patients with a history of stones.
  • Concomitant calcium intake: avoid excessive calcium supplementation without medical guidance.
  • Underlying granulomatous disease: use with caution in sarcoidosis or tuberculosis.
  • Pregnancy and lactation: safety not fully established; weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Colecalciferol may alter the pharmacokinetics or pharmacodynamics of several medicines.

Major Interactions (Avoid)

  • Thiazide diuretics: can increase risk of hypercalcaemia.
  • Vitamin A excess: synergistic hypercalcaemia risk.
  • Calcium‑containing antacids: may cause excessive calcium levels.

Moderate Interactions (Monitor Closely)

  • Orlistat: may reduce vitamin D absorption; separate dosing by at least 2 hours.
  • Anticonvulsants (e.g., phenytoin, phenobarbital): increase vitamin D metabolism, possibly reducing efficacy.
  • Glucocorticoids: may diminish vitamin D activity, requiring monitoring.
  • Bile acid sequestrants: can lower absorption of fat‑soluble vitamins.
  • Cholestyramine: may decrease vitamin D bioavailability.

Frequently Asked Questions

Lecalcif contains colecalciferol, a form of vitamin D3, and is used to correct vitamin D deficiency, prevent osteomalacia or rickets, and support bone health in conditions such as osteoporosis. It helps maintain adequate calcium and phosphate levels for normal bone mineralisation.

Colecalciferol is converted first in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active hormone binds to vitamin D receptors in intestinal cells, stimulating the production of calcium‑binding proteins that increase calcium and phosphate absorption from the gut, thereby supporting bone formation.

The appropriate dose of Lecalcif is determined by a qualified healthcare professional based on the individual’s serum vitamin D level, age, weight, underlying conditions, and concurrent medications. Patients should follow the prescriber’s instructions and not self‑adjust the dosage.

Safety data for colecalciferol in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any unknown risks before prescribing. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician.

To order Lecalcif, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lecalcif provides colecalciferol, the same active ingredient found in most vitamin D3 supplements. Differences among products may relate to dosage strength, formulation (tablet, capsule, liquid), and regulatory status. Clinicians choose a product based on the patient’s dosing needs, absorption considerations, and local availability.

Lecalcif should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat, and direct sunlight to maintain potency throughout its shelf life.

Lecalcif is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet or capsule should be swallowed whole with a glass of water. Patients should follow the specific administration instructions provided by their healthcare provider.

The most serious risks involve excessive calcium levels, known as hypercalcaemia, which can cause cardiac arrhythmias, kidney stones, or renal impairment. Rarely, severe allergic reactions such as anaphylaxis may occur. Patients should report symptoms like persistent nausea, vomiting, muscle weakness, or unusual fatigue to their doctor promptly.

Individuals with known hypersensitivity to colecalciferol or any excipients in the formulation should avoid Lecalcif. Patients with uncontrolled hypercalcaemia, severe renal disease, or certain granulomatous disorders (e.g., sarcoidosis) should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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