Product image of Lecalpin (Lercanidipine Hydrochloride) supplied by GNH India

Lecalpin

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lecalpin (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lecalpin, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to lower elevated blood pressure in adult patients diagnosed with hypertension.

GNH India supplies Lecalpin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Ireland Limited

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Indications & Clinical Uses

  • Lecalpin (Lercanidipine Hydrochloride) belongs to the calcium‑channel blocker class and is used to manage high‑blood‑pressure disorders.
  • Hypertension: reduces systemic vascular resistance, leading to a sustained decrease in blood pressure.

How It Works

  • Lercanidipine Hydrochloride selectively blocks L‑type calcium channels in vascular smooth‑muscle cells. By inhibiting calcium influx, it prevents contraction of arterial smooth muscle, producing vasodilation and a consequent reduction in peripheral resistance and arterial pressure without significant effect on cardiac contractility.

Side Effects

Lecalpin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: warmth and redness, usually occurring shortly after dosing.
  • Peripheral edema: swelling of ankles or lower legs.
  • Dizziness or light‑headedness, especially when standing.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reactions: rash, pruritus, or urticaria.
  • Angioedema: swelling of face, lips, or throat that may compromise airway.

Precautions & Warnings

  • Before initiating therapy with Lecalpin, clinicians should consider several safety aspects.
  • Monitor blood pressure regularly: ensure therapeutic effect and avoid excessive hypotension.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: tapering can reduce rebound hypertension.
  • Exercise caution in elderly patients: increased sensitivity to vasodilatory effects.
  • Contraindicated in known hypersensitivity to lercanidipine or other dihydropyridine calcium‑channel blockers.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lecalpin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma concentrations.
  • Concomitant use with other antihypertensives that cause vasodilation: risk of additive hypotension.
  • Grapefruit juice: can raise drug levels and precipitate adverse effects.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce effectiveness.

  • Non‑dihydropyridine calcium‑channel blockers (e.g., verapamil, diltiazem): may enhance cardiac effects.
  • Diuretics: may potentiate blood‑pressure lowering, requiring dose adjustments.

Frequently Asked Questions

Lecalpin contains lercanidipine hydrochloride, a calcium‑channel blocker that is prescribed to lower high blood pressure in adults with hypertension. By relaxing arterial smooth muscle, it helps achieve and maintain target blood‑pressure levels, reducing the risk of cardiovascular complications.

Lercanidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells. This inhibition prevents calcium‑induced contraction, leading to vasodilation of peripheral arteries, a fall in systemic vascular resistance, and ultimately a reduction in arterial blood pressure.

The appropriate dose of Lecalpin is determined by the prescribing healthcare professional based on the patient’s clinical condition, blood‑pressure response, and any co‑existing medical factors. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lecalpin belongs to the dihydropyridine calcium‑channel blocker class, offering potent arterial vasodilation with a relatively long half‑life, which allows once‑daily dosing. Compared with beta‑blockers or ACE inhibitors, it may cause fewer metabolic effects but can be associated with peripheral edema, a common class‑related side effect.

Lecalpin tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Keep the product away from moisture, heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Lecalpin is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed by a healthcare professional.

Serious adverse events, though rare, include severe hypotension, myocardial infarction, hepatic dysfunction, and allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience sudden dizziness, chest pain, jaundice, swelling of the face or throat, or any signs of an allergic response.

Lecalpin is contraindicated in individuals with known hypersensitivity to lercanidipine or other dihydropyridine calcium‑channel blockers. It should also be avoided in patients with severe aortic stenosis or uncontrolled heart failure unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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