Product image of Lecalpin (Lercanidipine Hydrochloride) supplied by GNH India

Lecalpin

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lecalpin (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lecalpin, is a calcium channel blocker presented as an oral tablet for systemic use. It is indicated for the management of hypertension in adult patients, helping to lower elevated blood pressure and reduce cardiovascular risk.

GNH India supplies Lecalpin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets across Europe, Asia, Africa and the Americas. Customers benefit from comprehensive technical support and on‑time delivery.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Lecalpin, a calcium channel blocker, is used to treat conditions related to elevated vascular resistance.

  • Hypertension: Reduces systolic and diastolic blood pressure, aiding long‑term cardiovascular risk management.

How It Works

  • Lercanidipine Hydrochloride selectively inhibits L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is necessary for contraction. This blockade induces vasodilation, decreases peripheral vascular resistance, and consequently lowers arterial blood pressure without significant negative inotropic effects on the heart.

Side Effects

Lecalpin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the lower limbs.
  • Dizziness or light‑headedness.
  • Tachycardia: increased heart rate.
  • Palpitations: awareness of heartbeats.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat.
  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Allergic reactions: rash, pruritus, or anaphylaxis.

Precautions & Warnings

Before initiating therapy with Lecalpin, clinicians should consider several safety measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Hepatic impairment: use with caution and adjust dose if necessary.
  • Elderly patients: start at the lowest effective dose due to increased sensitivity.
  • Concomitant antihypertensives: monitor for additive blood‑pressure‑lowering effects.
  • Discontinuation: avoid abrupt cessation to prevent rebound hypertension.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lecalpin can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase lercanidipine plasma levels.
  • Co‑administration with other potent antihypertensives: risk of excessive hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce drug efficacy.
  • Grapefruit juice: can elevate systemic exposure.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may attenuate antihypertensive effect.
  • Diuretics: monitor electrolytes and blood pressure.

Frequently Asked Questions

Lecalpin contains lercanidipine hydrochloride, which is prescribed to treat hypertension. By lowering high blood pressure, it helps reduce the risk of cardiovascular events such as stroke and heart attack in adult patients.

Lercanidipine blocks L‑type calcium channels in the smooth muscle of blood vessels. This inhibition prevents calcium‑mediated contraction, leading to vasodilation, reduced peripheral resistance, and a consequent fall in arterial blood pressure.

The appropriate dose of Lecalpin is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions exactly.

The safety of lercanidipine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified clinician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lecalpin belongs to the calcium channel blocker class, offering once‑daily dosing and a favorable side‑effect profile compared with some older agents. Compared with beta‑blockers or ACE inhibitors, it primarily reduces vascular resistance without significant effects on heart rate or renal function, making it a useful alternative or add‑on therapy.

Lecalpin tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.

Lecalpin is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious adverse events, though rare, include angioedema, severe hypotension, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, chest pain, or signs of liver dysfunction.

Lecalpin is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. It should also be avoided in individuals with severe hepatic impairment or those taking contraindicated strong CYP3A4 inhibitors without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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