Product image of Lecigen (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigen

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigen (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone/Levodopa/Carbidopa, the active ingredient in Lecigen, is a Levodopa/Carbidopa/Entacapone combination presented as a tablet for intestinal use. It treats Parkinson's disease in adults by improving motor control and reducing off‑periods.
GNH India supplies Lecigen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

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Indications & Clinical Uses

Lecigen is a fixed‑dose combination that targets the dopaminergic pathway in Parkinson's disease. It is used to manage motor symptoms and fluctuations in patients receiving levodopa therapy.

  • Parkinson's disease (motor fluctuations): reduces off‑time and stabilises symptom control.
  • Parkinson's disease (overall symptom control): improves gait, rigidity and tremor.
  • Parkinson's disease (adjunct therapy): allows lower levodopa dosing and may delay dose escalation.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, restoring deficient neurotransmission in Parkinson's disease. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing levodopa metabolism, prolonging its plasma half‑life and enhancing dopaminergic effect.

Side Effects

Lecigen may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dyskinesia: involuntary movements, especially at higher levodopa levels.
  • Orthostatic hypotension: dizziness upon standing.
  • Dizziness: general light‑headedness.
  • Constipation: reduced bowel motility.
  • Dry mouth: decreased salivation.

Serious or Rare Side Effects

  • Severe liver injury: elevated transaminases, jaundice.
  • Neuroleptic malignant‑like syndrome: high fever, muscle rigidity.
  • Severe allergic reactions: rash, angioedema, anaphylaxis.
  • Hyperpyrexia: uncontrolled high fever.
  • Severe depression or suicidal thoughts.
  • Hallucinations: visual or auditory disturbances.

Precautions & Warnings

When prescribing Lecigen, clinicians should consider several safety aspects.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution; monitor liver enzymes regularly.
  • Cardiovascular disease: observe for hypotension and arrhythmias.
  • Psychiatric history: watch for mood changes, depression, or hallucinations.
  • Concomitant MAO‑B inhibitors: avoid due to risk of hypertensive crisis.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Lecigen interacts with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Other COMT inhibitors: additive inhibition may cause excessive levodopa levels.
  • Anticholinergic agents: increased central side effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may enhance hypotensive effect.
  • SSRIs/SNRIs: monitor for serotonin syndrome.
  • Iron or calcium supplements: can reduce levodopa absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Lecigen is a fixed‑dose combination of entacapone, levodopa and carbidopa used as an adjunct therapy in Parkinson's disease. It helps improve motor symptoms and reduces off‑periods in patients already receiving levodopa, enhancing overall disease management.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its central availability. Entacapone inhibits the COMT enzyme, slowing levodopa metabolism, prolonging its plasma half‑life and strengthening dopaminergic stimulation.

The appropriate dose of Lecigen is individualized. A qualified prescriber determines the regimen based on the patient’s clinical response, disease stage and tolerability. Patients should never adjust the dose without medical guidance.

Safety data for Lecigen in pregnancy and lactation are limited, and the pregnancy category is unknown. It is generally avoided unless the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Lecigen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with levodopa alone, Lecigen adds entacapone, which extends levodopa’s half‑life and reduces dosing frequency, improving symptom stability. Relative to other COMT inhibitors such as tolcapone, entacapone has a lower risk of hepatotoxicity, making it a preferred option for many clinicians.

Lecigen should be stored at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and avoid exposure to excessive heat or humidity to maintain product integrity.

Lecigen is taken orally, usually with food to reduce gastrointestinal irritation. Tablets are swallowed whole with a full glass of water; they should not be crushed, chewed, or split unless specifically instructed by a healthcare professional.

Serious risks include severe liver injury, neuroleptic malignant‑like syndrome, marked hypotension, severe allergic reactions, and significant psychiatric changes such as depression or suicidal thoughts. Patients should seek immediate medical attention if they experience any of these symptoms.

Lecigen is contraindicated in individuals with known hypersensitivity to any component, those currently taking non‑selective MAO inhibitors, and patients with severe hepatic impairment. Caution is also advised for patients with narrow‑angle glaucoma or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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