Product image of Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigon

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone/Levodopa/Carbidopa, the active ingredient in Lecigon, is a combination dopamine precursor and COMT inhibitor presented as an oral tablet for intestinal use. It is prescribed to manage Parkinson's disease symptoms in adults, particularly those with motor fluctuations, by enhancing central dopamine availability.

GNH India supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across global markets while adhering to stringent quality and regulatory standards, including compliance with EU pharmacopeial specifications and reliable delivery timelines.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

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Indications & Clinical Uses

Lecigon, a combination antiparkinson agent, is used in the management of Parkinson's disease as part of levodopa‑based therapy.

  • Parkinson's disease (early or advanced): improves motor control and reduces OFF periods.
  • Motor fluctuations in Parkinson's disease: prolongs the effect of levodopa, decreasing dosing frequency.
  • Adjunct to levodopa therapy: enhances central dopamine levels, allowing better symptom control.

How It Works

  • Lecigon combines levodopa, a dopamine precursor, with carbidopa, an inhibitor of peripheral dopa decarboxylase, and entacapone, a catechol‑O‑methyltransferase (COMT) inhibitor. Carbidopa prevents levodopa conversion to dopamine outside the brain, increasing its availability for transport across the blood‑brain barrier. Once in the CNS, levodopa is decarboxylated to dopamine. Entacapone blocks COMT‑mediated methylation of levodopa in the periphery, further extending its plasma half‑life and sustaining dopaminergic stimulation.

Side Effects

Lecigon may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: loose stools often occurring early in therapy.
  • Dyskinesia: involuntary movements due to increased dopamine.
  • Orthostatic hypotension: dizziness upon standing.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe neutropenia: marked reduction in white blood cells.
  • Neuroleptic malignant‑like syndrome: high fever, muscle rigidity, altered mental status.

Precautions & Warnings

When prescribing Lecigon, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust therapy and monitor renal function.
  • Hepatic disease: use with caution; assess liver enzymes regularly.
  • Cardiovascular disorders: monitor blood pressure due to orthostatic effects.
  • Concomitant MAO‑B inhibitors: avoid simultaneous use to prevent hypertensive crisis.
  • Pregnancy and lactation: safety not established; weigh risks versus benefits.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture and light.

Avoid Interactions

Lecigon can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic agents: may exacerbate cognitive side effects.
  • CNS depressants (e.g., opioids, benzodiazepines): increase sedation and dizziness.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: orthostatic hypotension may be enhanced.
  • Iron or calcium supplements: reduce levodopa absorption; separate dosing by at least 2 hours.
  • SSRIs or SNRIs: may increase risk of serotonin syndrome when combined with MAO‑B inhibition.

Frequently Asked Questions

Lecigon is prescribed as an adjunct to levodopa therapy for the management of Parkinson's disease. It helps improve motor symptoms and reduces periods when medication effects wear off, known as OFF times, by increasing the amount of dopamine available in the brain.

The formulation combines three agents: levodopa, which crosses the blood‑brain barrier and is converted to dopamine; carbidopa, which blocks peripheral conversion of levodopa, allowing more to reach the brain; and entacapone, which inhibits the COMT enzyme that otherwise metabolises levodopa outside the CNS, thereby extending its therapeutic action.

Dosing of Lecigon is individualized. The prescribing clinician determines the appropriate strength, frequency and total daily dose based on the patient’s disease stage, response to therapy and tolerability. Patients should follow the specific instructions provided by their healthcare professional.

Safety of Lecigon in pregnancy and lactation has not been established. The potential benefits must be weighed against possible risks to the fetus or infant, and the decision should be made by a qualified healthcare provider in consultation with the patient.

To request Lecigon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecigon combines levodopa with carbidopa and entacapone, offering a broader pharmacologic profile than levodopa/carbidopa alone. The added COMT inhibition reduces levodopa breakdown, often resulting in smoother motor control and fewer dosing intervals compared with formulations that lack entacapone.

Lecigon tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Lecigon is taken orally, usually with a small amount of food to reduce gastrointestinal discomfort. The tablets are swallowed whole with water and should be taken at the times prescribed by the treating physician, often multiple times per day.

Serious adverse events can include hepatotoxicity, severe neutropenia and neuroleptic malignant‑like syndrome. Patients should be monitored for signs of liver dysfunction, unexplained infections or fever, and any sudden changes in mental status, and they should seek immediate medical attention if such symptoms arise.

Lecigon is contraindicated in patients with known hypersensitivity to any of its components, those taking non‑selective MAO inhibitors, and individuals with severe hepatic impairment. It should also be used with caution in patients with cardiovascular disease, renal insufficiency, or a history of dyskinesia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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