Product image of Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigon

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone, the active ingredient in Lecigon, is a Levodopa/Carbidopa/Entacapone combination presented as an oral tablet for intestinal use. It is prescribed to manage Parkinson's disease and to reduce motor fluctuations in patients already receiving levodopa/carbidopa therapy. The formulation combines levodopa, which is converted to dopamine in the brain, with carbidopa to inhibit peripheral metabolism, and entacapone to block catechol‑O‑methyltransferase, thereby enhancing and prolonging dopaminergic stimulation.

GNH India supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

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Indications & Clinical Uses

Lecigon, a Levodopa/Carbidopa/Entacapone combination, is used in the management of Parkinson's disease and related motor complications.

  • Parkinson's disease (adjunct therapy to levodopa/carbidopa): improves overall motor control and reduces symptom severity.
  • Motor fluctuations in Parkinson's disease: decreases OFF time and prolongs ON periods.
  • Wearing‑off phenomenon in Parkinson's disease: enhances dopaminergic stimulation to smooth daily motor performance.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring deficient central dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its plasma half‑life, which together provide more consistent dopaminergic stimulation.

Side Effects

Common Side Effects

  • Nausea: gastrointestinal upset occurring early in therapy.
  • Orthostatic hypotension: dizziness or light‑headedness upon standing.
  • Dyskinesia: involuntary movements linked to dopaminergic excess.
  • Insomnia: difficulty initiating or maintaining sleep.

Serious or Rare Side Effects

  • Severe liver injury: elevated transaminases requiring monitoring.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe diarrhea: may lead to dehydration.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Hallucinations: visual or auditory disturbances, especially in older patients.

Precautions & Warnings

Patients should be monitored for known risks associated with dopaminergic therapy.

  • Monitor blood pressure: watch for orthostatic changes.
  • Assess liver function: entacapone may affect hepatic enzymes.
  • Evaluate for psychiatric symptoms: hallucinations may occur.
  • Avoid use in patients with known hypersensitivity to any component.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Entacapone/Levodopa/Carbidopa may interact with several drug classes.

Major Interactions (Avoid)

  • MAO‑B inhibitors: increased risk of hypertensive crisis.
  • Non‑selective MAO inhibitors: severe hypertension.
  • Anticholinergic drugs: may worsen cognitive side effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive hypotensive effect.
  • Antipsychotics: may diminish dopaminergic response.

Frequently Asked Questions

Lecigon is a fixed‑dose combination of entacapone, levodopa and carbidopa indicated as adjunct therapy for Parkinson's disease and for the management of motor fluctuations such as wearing‑off phenomena in patients already receiving levodopa/carbidopa.

Entacapone inhibits catechol‑O‑methyltransferase (COMT), an enzyme that metabolises levodopa in the periphery. By blocking COMT, entacapone prolongs levodopa plasma levels, allowing more levodopa to reach the brain where it is converted to dopamine.

The specific dose and dosing schedule of Lecigon are determined by the prescribing clinician based on the individual patient's disease stage, response to therapy and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Lecigon in pregnancy and lactation has not been established. The product is classified as pregnancy category unknown, and it should only be used if the potential benefit justifies the potential risk to the fetus or infant. Consultation with a healthcare professional is essential.

To order Lecigon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecigon combines a COMT inhibitor (entacapone) with levodopa/carbidopa, offering longer and more stable levodopa exposure compared with levodopa/carbidopa alone. This can reduce OFF periods and motor fluctuations, whereas other agents such as MAO‑B inhibitors work via different enzymatic pathways.

Lecigon tablets should be stored at ambient temperature below 25 °C, kept in the original container, and protected from moisture and direct sunlight. Do not store in a refrigerator or freezer unless otherwise directed by the manufacturer.

Lecigon is taken orally, usually with food to minimise gastrointestinal irritation. The tablets are swallowed whole with a full glass of water. The exact timing relative to meals and other medications should follow the prescriber’s guidance.

Serious risks include severe liver injury, neuroleptic malignant syndrome, severe diarrhea, allergic reactions such as anaphylaxis, and hallucinations, particularly in older patients. Prompt medical attention is required if any of these events occur.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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