Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate)

Levodopa is converted to dopamine in the brain, while carbidopa prevents its breakdown in the periphery, allowing more levodopa to reach the central nervous system. Entacapone inhibits catechol‑O‑methyltransferase, further reducing peripheral metabolism of levodopa, which enhances and prolongs dopaminergic stimulation.

The appropriate dose of Lecigon is individualized and determined by the prescribing clinician based on disease severity, response to therapy, and patient tolerance. Patients should follow the dosage instructions provided by their healthcare professional and not adjust the regimen without medical advice.

Safety of Lecigon in pregnancy and lactation has not been established. The product carries an unknown pregnancy category, so clinicians should weigh potential benefits against risks and discuss options with the patient. Breastfeeding mothers should consult their physician before using the medication.

To order Lecigon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecigon combines levodopa and carbidopa with entacapone, whereas standard levodopa/carbidopa formulations lack the COMT inhibitor. The addition of entacapone prolongs levodopa's effect, often reducing the frequency of dosing and improving control of motor fluctuations compared with levodopa/carbidopa alone.

Lecigon tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Keep the product away from moisture, direct sunlight and heat sources to maintain stability and potency.

Lecigon is taken orally as a whole tablet, usually with water. It may be taken with or without food, but consistent timing relative to meals can help minimise gastrointestinal side effects. Patients should swallow the tablet whole and not split or crush it unless directed by a healthcare professional.

Serious risks include severe hypotension, liver injury, neuroleptic malignant syndrome, marked depression or suicidal thoughts, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden weakness, jaundice, high fever with rigidity, or any signs of severe allergic response.

Lecigon is contraindicated in individuals with known hypersensitivity to any of its components, severe hepatic impairment, narrow‑angle glaucoma, or those taking non‑selective MAO inhibitors. Caution is also advised for patients with a history of severe cardiovascular disease or psychiatric disorders.