Product image of Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigon

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone, Levodopa and Carbidopa, the active ingredients in Lecigon, are a combination of a MAO‑B inhibitor and a DOPA decarboxylase inhibitor presented as an oral tablet for intestinal use. It is indicated for the management of Parkinson's disease in adults.
GNH India supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

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Indications & Clinical Uses

Lecigon is a combination antiparkinson agent that targets motor symptoms and fluctuations in Parkinson's disease.

  • Parkinson's disease (early stage): improves motor function and reduces rigidity.
  • Parkinson's disease with motor fluctuations: decreases "off" periods and prolongs levodopa effect.
  • Advanced Parkinson's disease: enhances overall symptom control and supports daily activities.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, restoring deficient neurotransmission. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism, extending its plasma half‑life and enhancing clinical response.

Side Effects

Lecigon may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dyskinesia: involuntary movements, especially at higher doses.
  • Orthostatic hypotension: dizziness upon standing.
  • Headache: transient cranial discomfort.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated enzymes, requires immediate medical attention.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, life‑threatening.
  • Anaphylaxis: sudden allergic reaction with rash, swelling, breathing difficulty.

Precautions & Warnings

Before initiating Lecigon, clinicians should consider several safety measures.

  • Monitor for dyskinesia: adjust dose if involuntary movements appear.
  • Assess liver function: periodic tests are recommended due to potential hepatotoxicity.
  • Avoid abrupt discontinuation: taper gradually to prevent withdrawal effects.
  • Use caution in cardiovascular disease: orthostatic hypotension may exacerbate existing conditions.
  • Contraindicated in known hypersensitivity to any component.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lecigon can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Certain antihypertensives (e.g., alpha‑blockers): may cause severe hypotension.
  • Anticholinergic agents: can intensify central side effects.

Moderate Interactions (Monitor Closely)

  • SSRIs and other serotonergic drugs: monitor for serotonin syndrome.
  • Iron or dietary supplements: may reduce levodopa absorption; separate dosing by at least 2 hours.
  • Other Parkinson’s medications (e.g., dopamine agonists): dose adjustments may be needed.

Frequently Asked Questions

Lecigon is prescribed to manage Parkinson's disease. It combines levodopa, carbidopa and entacapone to improve motor symptoms, reduce "off" periods and provide more consistent dopamine levels in the brain.

Levodopa is a precursor that the brain converts into dopamine. Carbidopa blocks peripheral conversion of levodopa, allowing more to reach the brain. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its therapeutic effect.

The dose of Lecigon is individualized. A qualified prescriber determines the appropriate strength, frequency and total daily amount based on the patient’s clinical condition and response.

Safety data for Lecigon in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk, and the decision must be made by a healthcare professional.

Enquiries are submitted on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Standard levodopa/carbidopa provides dopamine replacement but has a shorter plasma half‑life. Adding entacapone, as in Lecigon, inhibits COMT, prolonging levodopa’s action, reducing "off" time and often allowing fewer daily doses.

Lecigon tablets should be stored at room temperature, below 25 °C, in the original container. Keep them away from moisture, heat and direct sunlight to maintain potency.

Lecigon is taken orally, usually with food to minimize gastrointestinal irritation. The tablets are swallowed whole with a glass of water and should be taken at the times prescribed by the treating physician.

Serious risks include severe liver injury, neuroleptic malignant syndrome, and anaphylactic reactions. Patients should seek immediate medical attention if they notice jaundice, high fever with muscle rigidity, or signs of a severe allergic response.

Lecigon is contraindicated in individuals with known hypersensitivity to entacapone, levodopa, carbidopa or any excipients, and in patients currently taking non‑selective MAO inhibitors. Caution is also advised for those with severe cardiovascular disease or liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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