Product image of Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigon

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone, Levodopa and Carbidopa, the active ingredients in Lecigon, are a COMT inhibitor/DOPA decarboxylase inhibitor combination presented as a tablet for intestinal use. It treats Parkinson's disease in adult patients by improving motor control and reducing fluctuations.

GNH India supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

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Indications & Clinical Uses

Lecigon is used in the management of Parkinsonian disorders, targeting dopamine deficiency and motor fluctuations.

  • Parkinson's disease (early stage): improves motor symptoms and reduces rigidity.
  • Parkinson's disease (advanced stage): helps maintain functional mobility and lessens "off" periods.
  • Parkinsonian motor fluctuations: smooths daily dopamine levels to decrease unpredictable symptom swings.

How It Works

  • Lecigon delivers levodopa, a dopamine precursor, while carbidopa blocks peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion. Entacapone inhibits peripheral catechol‑O‑methyltransferase, further reducing levodopa metabolism. The combined effect increases central dopamine availability, enhancing motor function and reducing the frequency of motor fluctuations in Parkinson's disease.

Side Effects

Lecigon may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness or light‑headedness: often related to orthostatic changes.
  • Dry mouth: reduced salivation leading to discomfort.
  • Constipation: slowed intestinal motility.
  • Hallucinations: visual or auditory disturbances, especially in older adults.
  • Dyskinesia: involuntary movements linked to levodopa exposure.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe liver injury: elevated transaminases requiring monitoring.
  • Hyperpyrexia: unexplained high fever with muscle rigidity.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Suicidal ideation: rare mood changes needing immediate attention.

Precautions & Warnings

Before initiating Lecigon, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic hypotension, especially at treatment start.
  • Assess liver function: periodic tests are advised due to entacapone metabolism.
  • Evaluate for dyskinesia: adjust levodopa dose if excessive movements appear.
  • Avoid abrupt discontinuation: sudden stop may worsen Parkinsonism.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lecigon can interact with other medicines, requiring careful review.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic agents: may increase confusion and cognitive decline.
  • CNS depressants: additive sedation and impaired coordination.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: may enhance hypotensive effects.
  • SSRIs or SNRIs: monitor for serotonin syndrome signs.
  • Iron or calcium supplements: can reduce levodopa absorption; separate dosing times.

Frequently Asked Questions

Lecigon is prescribed to manage Parkinson's disease. It combines levodopa with carbidopa and entacapone to increase central dopamine levels, helping to improve motor symptoms and reduce daily "off" periods in adult patients.

Levodopa serves as a dopamine precursor, while carbidopa blocks peripheral conversion of levodopa to dopamine, allowing more to reach the brain. Entacapone inhibits catechol‑O‑methyltransferase, further slowing levodopa breakdown. Together they raise dopamine availability and smooth motor control.

The specific dosage of Lecigon is determined by the prescribing clinician based on the individual’s disease stage, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Lecigon in pregnancy or while breastfeeding has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Lecigon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecigon combines a COMT inhibitor (entacapone) with levodopa/carbidopa, offering more stable dopamine levels than levodopa/carbidopa alone. Compared with dopamine agonists, it may produce fewer impulse‑control issues but can have a higher risk of dyskinesia, making it suitable for patients needing optimized levodopa response.

Lecigon should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Lecigon is taken orally, usually with food to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Dosing schedules are individualized, and patients should follow the timing and frequency prescribed by their healthcare provider.

Serious risks include neuroleptic malignant syndrome, severe liver injury, marked hypotension, and rare psychiatric effects such as suicidal thoughts. Patients should be monitored for any sudden changes in mood, temperature, muscle rigidity, or liver function and seek immediate medical attention if these occur.

Lecigon is contraindicated in patients with known hypersensitivity to any of its components, those taking non‑selective MAO inhibitors, or individuals with severe liver impairment. It should also be used with caution in patients with a history of cardiac arrhythmias or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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