Product image of Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigon

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigon (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone / Levodopa / Carbidopa, the active ingredient in Lecigon, is a COMT inhibitor and DOPA decarboxylase inhibitor combination presented as a combination tablet for oral use. It is used to treat Parkinson's disease and to manage motor fluctuations in patients with Parkinson's disease.

GNH India supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

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Indications & Clinical Uses

Lecigon, a COMT inhibitor and DOPA decarboxylase inhibitor combination, is used in the management of Parkinson’s disease and related motor fluctuations.

  • Parkinson's disease: improves motor symptoms by increasing central dopamine availability.
  • Motor fluctuations in Parkinson's disease: reduces “off” time and extends “on” periods.
  • Adjunct to levodopa therapy: enhances the effectiveness of levodopa in Parkinsonian patients.

How It Works

  • Entacapone blocks catechol‑O‑methyltransferase, slowing peripheral metabolism of levodopa and extending its plasma half‑life. Carbidopa inhibits aromatic L‑amino‑acid decarboxylase outside the brain, preventing conversion of levodopa to dopamine in the periphery and reducing peripheral side effects. The unchanged levodopa crosses the blood‑brain barrier, where neuronal aromatic L‑amino‑acid decarboxylase converts it to dopamine, restoring dopaminergic neurotransmission in the striatum.

Side Effects

Lecigon may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: upset stomach and urge to vomit.
  • Dizziness: feeling light‑headed or unsteady.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated enzymes, hepatic failure.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Allergic reactions: rash, swelling, anaphylaxis.

Precautions & Warnings

Before prescribing Lecigon, clinicians should consider several safety precautions.

  • Monitor liver function: perform baseline tests and periodic assessments.
  • Assess cardiovascular status: watch for hypotension and arrhythmias.
  • Review psychiatric history: be alert for hallucinations or confusion.
  • Avoid use in patients with known hypersensitivity to any component.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lecigon can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • MAO‑B inhibitors (e.g., selegiline, rasagiline): risk of hypertensive crisis.
  • Non‑selective MAO inhibitors (e.g., phenelzine): may cause severe hypertension.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive blood‑pressure lowering effect.
  • Antidiabetic drugs: possible masking of hypoglycemia symptoms.
  • Iron or calcium supplements: may reduce levodopa absorption if taken simultaneously.
  • Antipsychotics: can diminish levodopa’s therapeutic response.

Frequently Asked Questions

Lecigon is prescribed for the treatment of Parkinson's disease and to manage motor fluctuations that can occur in patients receiving levodopa therapy. It helps improve motor control and reduces periods when symptoms worsen.

Entacapone inhibits catechol‑O‑methyltransferase, prolonging levodopa's presence in the bloodstream. Carbidopa blocks peripheral conversion of levodopa to dopamine, allowing more levodopa to reach the brain. Once in the brain, levodopa is converted to dopamine, restoring deficient dopaminergic activity.

The dose of Lecigon is individualized. A qualified prescriber determines the appropriate strength, frequency, and total daily amount based on the patient's clinical condition, response to therapy, and tolerability.

Safety data for Lecigon in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a healthcare professional.

To order Lecigon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecigon combines levodopa with carbidopa and the COMT inhibitor entacapone, offering longer and more stable levodopa plasma levels than levodopa/carbidopa alone (e.g., Sinemet). This can reduce "off" periods and improve overall motor control, especially in patients experiencing fluctuations.

Lecigon tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Keep them away from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Lecigon is taken orally, usually with a glass of water. It can be taken with or without food, but consistent timing relative to meals helps maintain stable drug levels. Tablets should be swallowed whole and not chewed or crushed.

Serious risks include severe liver injury, neuroleptic malignant syndrome, and life‑threatening allergic reactions such as anaphylaxis. Patients should be monitored for signs of hepatic dysfunction, high fever with muscle rigidity, or any sudden allergic symptoms.

Lecigon is contraindicated in individuals with known hypersensitivity to entacapone, levodopa, carbidopa, or any excipients. It should also be avoided in patients currently taking non‑selective MAO inhibitors or those with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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