Product image of Lecigon, (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Lecigon,

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Lecigon, (Entacapone, Levodopa, Carbidopa Monohydrate)

Entacapone, the active ingredient in Lecigon, is a dopamine precursor combination (MAO‑B inhibitor + DOPA decarboxylase inhibitor) presented as an oral tablet for intestinal use. It is used to treat Parkinson's disease by enhancing and prolonging the effect of levodopa in adult patients.

GNH India supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lobsor Pharmaceuticals Ab

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Lecigon is a combination therapy that targets motor symptoms in Parkinson's disease and related levodopa‑induced fluctuations.

  • Parkinson's disease: improves overall motor control and reduces OFF periods.
  • Levodopa‑induced wearing‑off: prolongs levodopa plasma half‑life, decreasing dosing frequency.
  • Advanced Parkinson's disease with motor fluctuations: helps maintain more consistent dopaminergic stimulation.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, restoring deficient neurotransmission in Parkinson's disease. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its plasma half‑life, thereby providing more stable dopaminergic stimulation.

Side Effects

Lecigon may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dyskinesia: involuntary movements, especially at higher levodopa levels.
  • Dizziness: may occur when standing quickly.
  • Constipation: reduced bowel motility.
  • Dry mouth: decreased salivation.
  • Headache: transient cranial discomfort.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure drop requiring medical attention.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Agranulocytosis: dangerously low white‑blood‑cell count.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Psychiatric disturbances: hallucinations or confusion, especially in the elderly.

Precautions & Warnings

Before initiating Lecigon, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Renal impairment: assess kidney function and adjust monitoring as needed.
  • Hepatic impairment: use with caution; monitor liver enzymes regularly.
  • Cardiovascular disease: observe blood pressure for orthostatic changes.
  • Psychiatric history: watch for hallucinations, confusion, or mood swings.
  • Concomitant MAO‑B inhibitors: avoid combined use to prevent excessive dopaminergic activity.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lecigon interacts with several drug classes; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Certain antihypertensives (e.g., alpha‑blockers): may cause severe hypotension.
  • Antipsychotics with strong dopamine blockade: can diminish therapeutic effect.

Moderate Interactions (Monitor Closely)

  • SSRIs and SNRIs: may increase risk of serotonin syndrome.
  • Other dopaminergic agents (e.g., pramipexole): may enhance dopaminergic side effects.
  • Iron or calcium supplements: can reduce levodopa absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Lecigon is indicated as an adjunct to levodopa therapy for the treatment of Parkinson's disease. It helps improve motor symptoms and reduces the duration of OFF periods that can occur as the disease progresses.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its availability to the central nervous system. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its plasma half‑life, resulting in more stable dopaminergic stimulation.

The dose of Lecigon is individualized by the prescribing clinician based on the patient’s disease stage, response to therapy, and tolerability. Healthcare professionals determine the appropriate strength and dosing schedule for each patient.

Safety data for Lecigon in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lecigon combines a COMT inhibitor (entacapone) with levodopa and carbidopa, offering longer levodopa exposure than levodopa/carbidopa alone. Compared with other COMT inhibitors, it provides a similar efficacy profile, while the fixed‑dose combination simplifies dosing and may improve adherence.

Lecigon tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain product stability.

Lecigon is taken orally, usually with food to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Dosing frequency and timing are determined by the prescriber to align with the patient’s levodopa regimen.

Serious risks include severe hypotension, neuroleptic malignant syndrome, hepatic dysfunction, agranulocytosis, severe allergic reactions, and psychiatric disturbances such as hallucinations. Patients should be monitored closely for any of these events, especially during treatment initiation or dose adjustments.

Lecigon is contraindicated in patients with known hypersensitivity to entacapone, levodopa, carbidopa, or any excipients. It should also be avoided in individuals taking non‑selective MAO inhibitors or those with a history of severe hypotension or neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Entacapone, Levodopa, Carbidopa Monohydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT